Abstract
At present, the diagnosis of ischemic stroke mainly depends on neuroimaging technology, but it still has many limitations. Therefore, it is very important to find new biomarkers of ischemic stroke. Recently, β-actin has attracted extensive attention as a biomarker of a variety of cancers. Although several recent studies have been investigating its role in ischemic stroke and other cerebrovascular diseases, the understanding of this emerging biomarker in neurology is still limited. We examined human and preclinical studies to gain a comprehensive understanding of the literature on the subject. Most relevant literatures focus on preclinical research, and pay more attention to the role of β-actin in the process of cerebral ischemia, but some recent literatures reported that in human studies, serum β-actin increased significantly in the early stage of acute cerebral ischemia. This review will investigate the basic biology of β-actin, pay attention to the potential role of serum β-actin as an early diagnostic blood biomarker of ischemic stroke, and explore its potential mechanism in ischemic stroke and new strategies for stroke treatment in the future.
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Data Availability
Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.
Abbreviations
- ADF:
-
Actin depolymerization factor
- AJ:
-
Adhesion junction
- ATP:
-
Adenosine-triphosphate
- BBB:
-
Blood brain barrier
- DNA:
-
Deoxyribonucleic acid
- DNase I:
-
Deoxyribonuclease
- NMDA:
-
N-methyl-d-aspartic acid
- OGD:
-
Oxygen and glucose deprivation
- PD:
-
Parkinson disease
- TJ:
-
Tight junction
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This work was funded by Medical Health Science and Technology Project of Zhejiang Provincial Health Commission and Planned Projects of Bureau of Science and Technology of Zhoushan, Grant Nos. 2022KY1367, 2018C11044.
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Conceptualization—SH, JL, FD, XK, BW and JX, writing—JL, funding acquisition—SH, resources—SH, JL, FD, XK, BW and JX, supervision—SH.
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Li, J., Dai, F., Kou, X. et al. β-Actin: An Emerging Biomarker in Ischemic Stroke. Cell Mol Neurobiol 43, 683–696 (2023). https://doi.org/10.1007/s10571-022-01225-4
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DOI: https://doi.org/10.1007/s10571-022-01225-4