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Membrane tension buffering by caveolae: a role in cancer?

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Abstract

Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-1 and cavins, which are abundantly present at the plasma membrane of vertebrate cells. Since their discovery more than 60 years ago, the function of caveolae has been mired in controversy. The last decade has seen the characterization of new caveolae components and regulators together with the discovery of additional cellular functions that have shed new light on these enigmatic structures. Early on, caveolae and/or caveolin-1 have been involved in the regulation of several parameters associated with cancer progression such as cell migration, metastasis, angiogenesis, or cell growth. These studies have revealed that caveolin-1 and more recently cavin-1 have a dual role with either a negative or a positive effect on most of these parameters. The recent discovery that caveolae can act as mechanosensors has sparked an array of new studies that have addressed the mechanobiology of caveolae in various cellular functions. This review summarizes the current knowledge on caveolae and their role in cancer development through their activity in membrane tension buffering. We propose that the role of caveolae in cancer has to be revisited through their response to the mechanical forces encountered by cancer cells during tumor mass development.

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Acknowledgments

We thank all the members of our laboratory for stimulating discussions.

Funding

This work was supported by institutional grants from the Curie Institute, INSERM, and CNRS, and by specific grants from Agence Nationale de la Recherche (MOTICAV ANR-17-CE-0013 and sCAV-BandPC ANR-19-CE15) and Institut National du Cancer (INCa PLBIO18-01 INVADOCAV). Vibha Singh is supported by a post-doctoral fellowship from Fondation pour la Recherche Médicale (FRM # SPF201909009115). The Lamaze laboratory is a member of Labex Cell(n)Scale ANR-11-LBX-0038, part of the IDEX PSL ANR-10-IDEX-0001-02.

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  1. UMR3666, INSERM U1143, Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS, 75005, Paris, France

    Vibha Singh & Christophe Lamaze

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Singh, V., Lamaze, C. Membrane tension buffering by caveolae: a role in cancer?. Cancer Metastasis Rev 39, 505–517 (2020). https://doi.org/10.1007/s10555-020-09899-2

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