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Effect and Mechanism of Curdione Combined with Gemcitabine on Migration and Invasion of Bladder Cancer

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Abstract

Bladder cancer (BCa), which usually occurs in bladder epithelial cells and is the fifth most common type of cancer in the world. he recurrence rate within 5 years after surgery is 0.8–45% of patients with early bladder cancer. Therefore, finding appropriate drug therapy for patients with bladder cancer can provide a reference for clinical treatment and play an important role in improving the prognosis of patients. In this study, CCK8 assay result showed that the inhibition of bladder cancer cell activity by Curdione and GEM increased with time and dose. Subsequently, CCK8, clone formation assay and Transwell result showed Curdione enhances GEM inhibition of bladder cancer cell activity, clonal formation and migration, these combine therapeutic schedule also could inhibited growth of in vivo xenograft tumors. The comprehensive database showed that CA2 is a potential target genes of Curdione, and Knockdown CA2 enhances GEM induced inhibition of cell proliferation and migration. Based on these advantages, Curdione may be a new type of action drug or adjunct for the treatment of bladder cancer.

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The original contributions presented in the study are included in the article, and further inquiries can be directed to the corresponding authors.

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Funding

This work was supported by Provincial Higher Education Institutions in Heilongjiang Province Basic research business expenses Research projects in 2022,China (Grant No. 2022-KYYWF-0634), Jiamusi University Doctoral Special Research Fund Launch Project in 2022(grant no.JMSUBZ2021-14).

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Authors and Affiliations

  1. Department of Urology, The First Affiliated Hospital of Jiamusi University, Heilongjiang, 154002, People’s Republic of China

    Bao-Jin Chi

  2. Graduate School, Jiamusi University, 148 Xuefu Road, Jiamusi, Heilongjiang, 154007, People’s Republic of China

    Zhong-Lei Duan & Bo-Yang Cui

  3. International Student College, Jiamusi University, Heilongjiang, 154007, People’s Republic of China

    Al-Kamel Haithm Ali Mohammed Hasan

  4. Basic Medical College, Jiamusi University, Heilongjiang, 154007, People’s Republic of China

    Xing-Zhong Yin & Fang-Fang Wang

Authors
  1. Bao-Jin Chi
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  2. Zhong-Lei Duan
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  3. Al-Kamel Haithm Ali Mohammed Hasan
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  4. Xing-Zhong Yin
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  5. Bo-Yang Cui
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  6. Fang-Fang Wang
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Contributions

The main idea of this project and Conceptualization developed by Fang-Fang Wang. The experiments were designed by Fang-Fang Wang and Zhong-Lei Duan. Bao-Jin Chi, The experiments performed by Bao-Jin Chi. The flow cytometry part of experiment performed by Zhong-Lei Duan, Bao-Jin Chi and Fang-Fang Wang wrote the main manuscript text. L-KAMEL HAITHM ALI MOHAMMED HASAN3, Xing-Zhong Yin wrote the methodology, result and prepared the figure related to it. The rest of tables and figures were prepared by Bo-Yang Cui. All authors reviewed the manuscript.

Corresponding authors

Correspondence to Zhong-Lei Duan or Fang-Fang Wang.

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Chi, BJ., Duan, ZL., Hasan, AK.H.A.M. et al. Effect and Mechanism of Curdione Combined with Gemcitabine on Migration and Invasion of Bladder Cancer. Biochem Genet (2023). https://doi.org/10.1007/s10528-023-10584-6

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  • DOI: https://doi.org/10.1007/s10528-023-10584-6

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