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Comprehensive Analysis for Predicting Prognoses and Immune Responses of m6A-Related lncRNAs in Women with Lung Adenocarcinoma

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Abstract

During the past decade, the average 5-year survival rate of patients with Lung adenocarcinoma (LUAD) has remained < 20%, although the targeted therapies and novel immunotherapy approaches have held promise. Epigenetic modifications could provide prognostic value as molecular biomarkers, and we aimed to identify the independent risk of m6A-related lncRNAs to establish a risk model for the clinical prediction of prognoses in women with LUAD. In this study, we first assessed 31 N6-methyladenosine (m6A)-related lncRNAs associated with overall survival. Moreover, we evaluated the expression of the oncogenic driver and the tumor immune microenvironment (TIME) in two female LUAD subtypes (clusters 1 and 2) using consensus clustering. We also found 16 m6A-related lncRNAs as the independent prognostic indicator of women with LUAD and established a risk model developed from these lncRNAs. We comprehensively investigated the correlation between the TIME and m6A-related lncRNA and found that m6A-related lncRNA may significantly affect the immune cell infiltration level in LUAD. In conclusion, our study provides evidence on the prognostic prediction in women with LUAD and may help elucidate the processes and mechanisms of m6A-regulated lncRNAs.

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Acknowledgements

The authors report no conflicts of interest in this work. We would like to thank Editage (www.editage.com) for English language editing.

Funding

This work was supported by the Changsha Natural Science Foundation of China (Grant Number: kq2014230).

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, #139 Renmin Road, Changsha, 410011, Hunan, China

    Sijie Wu, Qinxian Tu, Haoyong Yuan, Zhongshi Wu, Yifeng Yang, Chunyang Chen & Can Huang

  2. Engineering Laboratory of Hunan Province for Cardiovascular Biomaterials, Changsha, 410008, Hunan, China

    Haoyong Yuan, Zhongshi Wu, Chunyang Chen & Can Huang

Authors
  1. Sijie Wu
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  2. Qinxian Tu
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  3. Haoyong Yuan
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  4. Zhongshi Wu
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  5. Yifeng Yang
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  6. Chunyang Chen
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  7. Can Huang
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Contributions

CH, ZW, and HY developed the idea of the study, participated in its design and coordination and helped to draft the manuscript. SW and WW contributed to the acquisition and interpretation of data. YY and CC provided critical review and substantially revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Can Huang.

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Wu, S., Tu, Q., Yuan, H. et al. Comprehensive Analysis for Predicting Prognoses and Immune Responses of m6A-Related lncRNAs in Women with Lung Adenocarcinoma. Biochem Genet (2023). https://doi.org/10.1007/s10528-023-10572-w

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