Abstract
Conformation and kinetic characteristics of the interactions of local anesthetics lidocaine (xycaine), tetracaine (dicaine), bupivacaine, and new RU-1117 compound with proven anesthetic activity with Visiton (1% hydroxypropylmethylcellulose in phosphate buffer) were studied. It was found that complex formation between the local anesthetics and hydroxypropylmethylcellulose is a time-dependent reversible process. The equilibrium is attained within 2.5–8.0 h and depends on the chemical nature of local anesthetic.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 5, pp. 563–567, May, 2007
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Galenko-Yaroshevskii, A.P., Varlashkina, I.A., Takhchidi, K.P. et al. Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of hydroxypropylmethylcellulose. Bull Exp Biol Med 143, 626–629 (2007). https://doi.org/10.1007/s10517-007-0200-1
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DOI: https://doi.org/10.1007/s10517-007-0200-1