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The effect of hyperoxia on muscle sympathetic nerve activity: a systematic review and meta-analysis

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Abstract

Purpose

We conducted a meta-analysis to determine the effect of hyperoxia on muscle sympathetic nerve activity in healthy individuals and those with cardio-metabolic diseases.

Methods

A comprehensive search of electronic databases was performed until August 2022. All study designs (except reviews) were included: population (humans; apparently healthy or with at least one chronic disease); exposures (muscle sympathetic nerve activity during hyperoxia or hyperbaria); comparators (hyperoxia or hyperbaria vs. normoxia); and outcomes (muscle sympathetic nerve activity, heart rate, blood pressure, minute ventilation). Forty-nine studies were ultimately included in the meta-analysis.

Results

In healthy individuals, hyperoxia had no effect on sympathetic burst frequency (mean difference [MD] − 1.07 bursts/min; 95% confidence interval [CI] − 2.17, 0.04bursts/min; P = 0.06), burst incidence (MD 0.27 bursts/100 heartbeats [hb]; 95% CI − 2.10, 2.64 bursts/100 hb; P = 0.82), burst amplitude (P = 0.85), or total activity (P = 0.31). In those with chronic diseases, hyperoxia decreased burst frequency (MD − 5.57 bursts/min; 95% CI − 7.48, − 3.67 bursts/min; P < 0.001) and burst incidence (MD − 4.44 bursts/100 hb; 95% CI − 7.94, − 0.94 bursts/100 hb; P = 0.01), but had no effect on burst amplitude (P = 0.36) or total activity (P = 0.90). Our meta-regression analyses identified an inverse relationship between normoxic burst frequency and change in burst frequency with hyperoxia. In both groups, hyperoxia decreased heart rate but had no effect on any measure of blood pressure.

Conclusion

Hyperoxia does not change sympathetic activity in healthy humans. Conversely, in those with chronic diseases, hyperoxia decreases sympathetic activity. Regardless of disease status, resting sympathetic burst frequency predicts the degree of change in burst frequency, with larger decreases for those with higher resting activity.

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Data availability

Data will be provided following a reasonable request to the corresponding author.

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Acknowledgements

We would like to thank the authors who clarified aspects of their published data that were included in our meta-analysis.

Funding

This study was funded by a National Sciences and Engineering Research Council Discovery Grant (Craig Steinback: RGPIN–2020–05385). Margie Davenport is supported by the Christenson Professorship in Healthy Active Living.

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Authors and Affiliations

  1. Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada

    Desmond A. Young, Paris A. T. Jones, Brittany A. Matenchuk, Margie H. Davenport & Craig D. Steinback

  2. Program for Pregnancy and Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, Women and Children’s Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada

    Brittany A. Matenchuk & Margie H. Davenport

  3. Geoffrey and Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, AB, Canada

    Allison Sivak

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Desmond Young, Craig Steinback, and Margie Davenport conceptualized the project. Allison Sivak performed the literature search. Desmond Young, Paris Jones, Brittany Matenchuk, and Craig Steinback performed data analysis. Desmond Young drafted the manuscript, and all authors critically revised the work.

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Correspondence to Craig D. Steinback.

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Young, D.A., Jones, P.A.T., Matenchuk, B.A. et al. The effect of hyperoxia on muscle sympathetic nerve activity: a systematic review and meta-analysis. Clin Auton Res 34, 233–252 (2024). https://doi.org/10.1007/s10286-024-01033-4

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