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Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

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Abstract

Endodontics has gained emphasis in the scientific community in recent years due to the increase in clinical and in animal models studies focused on endodontic medicine, which aims to evaluate the interrelationship between systemic and periapical tissues pathological conditions. These studies have shown that systemic changes can boost the pathogenesis of endodontic infection, favoring its development and progression. A contrary relationship is reported in numerous studies that affirm the potential of endodontic infection to trigger systemic damage and may lead to the worsening of pre-existing pathologies. Recently, the potential of filling materials to develop systemic changes such as neurological alterations had been evaluated, also showing that systemic diseases can negatively influence tissue responses to filling materials after endodontic treatment. Despite advances in endodontic medicine studies, there are still gaps in knowledge on the mechanisms of interactions between apical periodontitis (AP) and systemic diseases and much research to be done. In this sense, this critical narrative literature review aimed to show the evolution of studies in endodontic medicine to help the endodontist to know the role of systemic diseases in the pathogenesis of AP and the possible interference in the repair of periapical tissues after endodontic treatment, as well as to evidence the systemic complications that can be triggered or aggravated in the presence of endodontic infection.

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Funding

This study was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (311650/2018-0).

Author information

Authors and Affiliations

  1. Department of Preventive and Restorative Dentistry, Endodontic Section, School of Dentistry, São Paulo State University (Unesp), José Bonifácio, 1193, Vila Mendonça, Araçatuba, SP, CEP 16015-050, Brazil

    Luciano Tavares Angelo Cintra, Cristiane Cantiga da Silva & Flávio Duarte Faria

  2. Dental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (Unesp), School of Dentistry, Araçatuba, SP, Brazil

    Luciano Tavares Angelo Cintra

  3. Departament of Odontology, School of Dentistry and Medical and Dental Center, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    Maximiliano Schünke Gomes

  4. Department of Restorative Dentistry, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil

    Francine Benetti

  5. Department of Clinics and Surgery, School of Dentistry, Federal University of Alfenas (Unifal), Alfenas, MG, Brazil

    Leopoldo Cosme-Silva

  6. Department of Clinical Dentistry, Dental School, Universidade de Uberaba, Uberaba, MG, Brazil

    Renata Oliveira Samuel

  7. Department of Oral Pathology and Oral Medicine, Dental School of Amazonas State University, Manaus, AM, Brazil

    Tiago Novaes Pinheiro

  8. Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás (UFG), Goiânia, GO, Brazil

    Carlos Estrela

  9. Department of Dental Clinics, University of Guadalajara, Guadalajara, Mexico

    Alvaro Cruz González

  10. Department of Stomatology, School of Dentistry, University of Sevilla, Sevilla, Spain

    Juan José Segura-Egea

Authors
  1. Luciano Tavares Angelo Cintra
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  2. Maximiliano Schünke Gomes
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  3. Cristiane Cantiga da Silva
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  4. Flávio Duarte Faria
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  5. Francine Benetti
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  6. Leopoldo Cosme-Silva
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  7. Renata Oliveira Samuel
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  8. Tiago Novaes Pinheiro
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  9. Carlos Estrela
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  10. Alvaro Cruz González
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  11. Juan José Segura-Egea
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Corresponding author

Correspondence to Luciano Tavares Angelo Cintra.

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Cintra, L.T.A., Gomes, M.S., da Silva, C.C. et al. Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions. Odontology 109, 741–769 (2021). https://doi.org/10.1007/s10266-021-00636-x

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