Abstract
Retinoblastoma (RB), the most common malignant retinal tumor among children under 3 years old, is lethal if left untreated. Early diagnosis, together with timely and effective treatment, is important to improve retinoblastoma-related outcomes. Circular RNAs (circRNAs), a new class of non-coding RNAs with the capacity to regulate cellular activities, have great potential in retinoblastoma diagnosis and treatment. Recent studies have identified circular RNAs that regulate multiple cellular processes involved in retinoblastoma, including cell viability, proliferation, apoptosis, autophagy, migration, and invasion. Six circular RNAs (circ-FAM158A, circ-DHDDS, circ-E2F3, circ-TRHDE, circ-E2F5, and circ-RNF20) promote disease progression and metastasis in retinoblastoma and function as oncogenic factors. Other circular RNAs, such as circ-TET1, circ-SHPRH, circ-MKLN1, and circ-CUL2, play tumor suppressive roles in retinoblastoma. At present, the studies on the regulatory mechanism of circular RNAs in retinoblastoma are not very clear. The purpose of this review is to summarize recent studies on the functional roles and molecular mechanisms of circular RNAs in retinoblastoma and highlight novel strategies for retinoblastoma diagnosis, prognosis, and treatment.
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Data Availability
All data generated during this study are included in this published article.
Abbreviations
- RB :
-
Retinoblastoma
- circRNA :
-
Circular RNA
- EMC9 :
-
Endoplasmic reticulum membrane protein complex subunit 9
- XIAP :
-
X-linked inhibitor of apoptosis protein
- HDAC :
-
Histone deacetylase
- TGFbeta :
-
Transforming growth factor beta
- TNM :
-
Tumor-node metastasis
- E2F3 :
-
E2F transfection factor 3
- ROCK1 :
-
Rho-associated protein kinase 1
- HNRNPK :
-
Heterogeneous ribosomal protein K
- LASP1 :
-
LIM and SH3 protein 1
- TRHDE :
-
Thyrotropin-releasing hormone-degrading enzyme
- E2F5 :
-
E2F transcription factor 5
- TET1 :
-
Tet methylcytosine dioxygenase 1
- SHPRH :
-
Snf2 histone linker Phd ring helicase
- E2F2 :
-
E2F transcription factor 2
- RBPs :
-
RNA blinding proteins
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This research was funded by National Natural Science Foundation of China [81500763]; Shandong Provincial Natural Science Foundation, China [ZR2020MC059]; China Postdoctoral Science Foundation [2019M652311]; special support for post-doc creative funding in Shandong province; and Applied Research Program for Post-Doctoral in Qingdao.
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X.D.H. designed the research; F.L. wrote the manuscript; K.Y.Y., P.H.G., and T.J.Z. organized the material; X.D.H. and F.L. revised the manuscript. All authors read and approved the final manuscript.
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Li, F., Yin, YK., Zhang, JT. et al. Role of circular RNAs in retinoblastoma. Funct Integr Genomics 23, 13 (2023). https://doi.org/10.1007/s10142-022-00942-9
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DOI: https://doi.org/10.1007/s10142-022-00942-9