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Investigation of the efficiency and stability of a novel visualized lattice CO2 laser–based gynecological therapeutic apparatus for the treatment of cervical diseases in rhesus monkeys

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Abstract

The fractional CO2 laser is a type of ablative laser. In this study, a novel fractional CO2 laser therapeutic apparatus was developed for cervical diseases. To compare the depth and diameter of penetration as well as the stability of a novel laser against a control laser emitting at the same wavelength, we tested this using a rhesus monkey model. The cervixes of rhesus monkeys were irradiated with the novel CO2 laser. The effects of irradiation were assessed by measuring the depths and diameters of the holes created by the laser. In addition, the depths and diameters of the holes were compared between the novel CO2 laser–based gynecological therapeutic apparatus and the conventional CO2 laser–based therapeutic apparatus. When operated under the single spot mode and at the same energy level, the novel CO2 laser–based gynecological therapeutic apparatus created holes that could reach the greater depth. In addition, the laser spot size of the new apparatus was more constant. Moreover, there were no significant differences in the side effects between the new apparatus and the conventional apparatus. The results indicate that the novel CO2 laser–based gynecological therapeutic apparatus exhibits better stability in comparison to the conventional CO2 laser–based therapeutic apparatus.

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Funding

This study was supported by the Open Research Fund Program of China Medical Laser (Beijing) Technology Co., Ltd.

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Authors and Affiliations

  1. Department of Gynaecology and Obstetrics, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing, China

    Fei Chen

  2. China Medical Laser (Beijing) Technology Co., Ltd, Beijing, China

    Yin Gan

  3. Department of Dermatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College(PUMC), Beijing, China

    Hong-Wei Wang

Authors
  1. Fei Chen
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  2. Yin Gan
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  3. Hong-Wei Wang
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Correspondence to Hong-Wei Wang.

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All procedures performed in the study were in accordance with the ethical standards of the Capital Medical University research committee.

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The authors declare no competing interests.

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Chen, F., Gan, Y. & Wang, HW. Investigation of the efficiency and stability of a novel visualized lattice CO2 laser–based gynecological therapeutic apparatus for the treatment of cervical diseases in rhesus monkeys. Lasers Med Sci 37, 2413–2420 (2022). https://doi.org/10.1007/s10103-021-03499-4

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  • DOI: https://doi.org/10.1007/s10103-021-03499-4

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