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Applications and perspectives of polyphenol-loaded solid lipid nanoparticles and nanostructured lipid carriers for foods

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Abstract

Imbalanced nutrition in modern society is one of the reasons for disorders, such as cancer, cardiovascular disease, and diabetes, which have attracted the interest in bioactives (particularly polyphenols) to assist in the balanced diet of modern people. Although stability can be maintained during preparation and storage, the ingested polyphenols undergo harsh gastrointestinal digestion processes, resulting in limited bioaccessibility and low gut-epithelial permeation and bioavailability. Several lipid-based formulations have been proposed to overcome these issues. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have also been highlighted as carrier systems for the oral delivery of lipophilic bioactives, including polyphenols. This paper summarizes the research on the ingredients, production methods, post-processing procedures, general characteristics, and advantages and disadvantages of SLNs and NLCs. Overall, this paper reviews the applications and perspectives of polyphenol-loaded SLNs and NLCs in foods, as well as their regulation, production, storage, and economic feasibility.

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Acknowledgements

This study was supported by the 2021 Research Fund of the University of Seoul.

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  1. Eunghee Kim and Choongjin Ban have contributed equally to this study.

Authors and Affiliations

  1. Department of Agricultural Biotechnology, Seoul National University, Gwanakgu, Seoul, 08826, Republic of Korea

    Eunghee Kim & Young Jin Choi

  2. Department of Environmental Horticulture, University of Seoul, Dongdaemungu, Seoul, 02504, Republic of Korea

    Choongjin Ban

  3. Department of Plant and Food Sciences, Sangmyung University, Cheonan, Chungnam, 31066, Republic of Korea

    Sang-Oh Kim

  4. Department of Food Science and Biotechnology, Gachon University, Seongnam, Gyeonggi, 13120, Republic of Korea

    Seokwon Lim

  5. Center for Food and Bioconvergence, Seoul National University, Gwanakgu, Seoul, 08826, Republic of Korea

    Young Jin Choi

  6. Research Institute for Agriculture and Life Sciences, Seoul National University, Gwanakgu, Seoul, 08826, Republic of Korea

    Young Jin Choi

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Kim, E., Ban, C., Kim, SO. et al. Applications and perspectives of polyphenol-loaded solid lipid nanoparticles and nanostructured lipid carriers for foods. Food Sci Biotechnol 31, 1009–1026 (2022). https://doi.org/10.1007/s10068-022-01093-0

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