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Ribosomal proteins induce stem cell-like characteristics in glioma cells as an “extra-ribosomal function”

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Abstract

The characteristic features of plasticity and heterogeneity in glioblastoma (GB) cells cause therapeutic difficulties. GB cells are exposed to various stimuli from the tumor microenvironment and acquire the potential to resist chemoradiotherapy. To investigate how GB cells acquire stem cell-like phenotypes, we focused on ribosomal proteins, because ribosome incorporation has been reported to induce stem cell-like phenotypes in somatic cells. Furthermore, dysregulation of ribosome biogenesis has been reported in several types of cancer. We focused on ribosomal protein S6, which promotes sphere-forming ability and stem cell marker expression in GB cells. We expect that investigation of dysregulation of ribosome biogenesis and extra-ribosomal function in GB will provide new insights about the plasticity, heterogeneity, and therapeutic resistance of GB cells, which can potentially lead to revolutionary therapeutic strategies.

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Acknowledgements

This work was supported by Grants-in-Aid for Scientific Research (C) Grant Number JP20K09374 (to Takuichiro Hide) from Ministry of Education, Culture, Sports, Science and Technology.

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Authors and Affiliations

  1. Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan

    Takuichiro Hide, Ichiyo Shibahara, Madoka Inukai, Ryota Shigeeda & Toshihiro Kumabe

  2. Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, chuo-ku, Kumamoto, 860-8556, Japan

    Yuki Shirakawa & Hirofumi Jono

  3. Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 850-8556, Japan

    Naoki Shinojima & Akitake Mukasa

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  1. Takuichiro Hide
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  3. Madoka Inukai
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Correspondence to Takuichiro Hide.

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Hide, T., Shibahara, I., Inukai, M. et al. Ribosomal proteins induce stem cell-like characteristics in glioma cells as an “extra-ribosomal function”. Brain Tumor Pathol 39, 51–56 (2022). https://doi.org/10.1007/s10014-022-00434-5

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