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Ion-selective electrodes for the determination of l-carnitine. Application in dissolution testing of a dietary supplement

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Abstract

l-Carnitine selective electrodes were developed using polymeric membranes containing a lipophilic cation exchanger (potassium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate) and plasticized with three different plasticizers: bis(2-ethylhexyl) sebacate, tricresyl phosphate, and 2-nitrophenyl octyl ether. The response of the electrodes was evaluated in terms of calibration parameters (slope, limit of detection, and linear range), reproducibility, selectivity profile, and pH influence. The electrodes were applied to the dissolution testing of a dietary supplement containing l-carnitine in water and in HCl (pH = 3) by direct potentiometric monitoring.

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References

  1. Dabrowska M, Starek M (2014) Food Chem 142:220

    Article  CAS  Google Scholar 

  2. Ramsay RR, Gandour RD, Van de Leij FR (2001) Biochim Biophys Acta 1546:21

    Article  CAS  Google Scholar 

  3. Steiber A, Kerner J, Hoppel CL (2004) Mol Espects Med 25:455

    Article  CAS  Google Scholar 

  4. Kerner J, Hoppel CL (2000) Biochim Biophys Acta 1486:1

    Article  CAS  Google Scholar 

  5. Matsui S, Sugita T, Matoba M, Murakami E, Takekoshi N, Shinka T, Masumoto I (1994) Clin Cardiol 17:301

    Article  CAS  Google Scholar 

  6. Zammit VA, Ramsay RR, Bonomini M, Arduini A (2009) Adv Drug Deliver Rev 61:1353

    Article  CAS  Google Scholar 

  7. Bianchetti A, Rozzini R, Trabucchi M (2003) Curr Med Res Opin 19:350

    CAS  Google Scholar 

  8. El-Beshlawy A, Ragab L, Fattah AA, Ibrahim IY, Hamdy M, Makhlouf A, Aoun E, Hoffbrand V, Taher A (2004) Acta Haematol-Basel 111:143

    Article  CAS  Google Scholar 

  9. Bellinghieri G, Santor D, Calvani M, Mallamace A, Savica V (2003) Am J Kidney Dis 41:116

    Article  Google Scholar 

  10. Cave MC, Hurt RT, Frazier TH, Matheson PJ, Garrison RN, McClain CJ, McClave SA (2008) Nut Clin Pract 23:16

    Article  Google Scholar 

  11. Wutzke KC, Lorenz H (2004) Metabolism 53:1002

    Article  CAS  Google Scholar 

  12. Karlic H, Lohninger A (2004) Nutrition 20:709

    Article  CAS  Google Scholar 

  13. Möder M, Kieβling A, Löster H (2005) Monatsh Chem 136:1279

    Article  Google Scholar 

  14. Li K, Li W, Huang Y (2007) Clin Chim Acta 378:159

    Article  CAS  Google Scholar 

  15. Freimüller S, Altorfer H (2002) J Pharm Biomed 30:209

    Article  Google Scholar 

  16. Prokorátová V, Kvasnika F, Sevcik R, Voldrich M (2005) J Chromatogr A 1081:60

    Article  Google Scholar 

  17. Manjón A, Obón JM, Iborra JL (2000) Anal Biochem 281:176

    Article  Google Scholar 

  18. Ratko AA, Stefan RI, Van Staden JF, Aboul-Enein HY (2004) Talanta 63:515

    Article  CAS  Google Scholar 

  19. Umezawa Y, Bühlmann P, Umezawa K, Tohda K, Amemiya S (2000) Pure Appl Chem 72:1851

    Article  CAS  Google Scholar 

  20. Xiao KP, Bühlmann P, Nishizawa S, Amemiya S, Umezawa Y (1997) Anal Chem 69:1038

    Article  CAS  Google Scholar 

  21. Zhang Y, Bredael G, Armenante PM (2013) J Pharm Sci 102:2718

    Article  CAS  Google Scholar 

  22. Limberg J, Potthast H (2013) Biopharm Drug Dispos 34:247

    Article  CAS  Google Scholar 

  23. Ortuño JA, Cuartero M, Garcia MS, Albero MI (2010) Electrochim Acta 55:5598

    Article  Google Scholar 

  24. Cuartero M, Ortuño JA, Garcia MS, Garcia-Cánovas F (2012) Anal Biochem 421:208

    Article  CAS  Google Scholar 

  25. Garcia MS, Ortuño JA, Albero MI, Cuartero M (2009) Anal Bioanal Chem 394:1563

    Article  CAS  Google Scholar 

  26. Rezk MS, El Nashar RM (2013) Bioelectrochem 89:26

    Article  CAS  Google Scholar 

  27. Bakker E, Pretsch E, Buhlmann P (2000) Anal Chem 72:1127

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We gratefully acknowledge the financial support of the Ministerio de Ciencia y Tecnología, Spain (project CTQ2011-27049). M.C.B thanks the University of Murcia for a grant.

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Author notes

  1. María Cuartero

    Present address: Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest-Ansermet 30, 1211, Geneva, Switzerland

Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence “Campus Mare Nostrum”, University of Murcia, Murcia, 30100, Spain

    María Cuartero, Soraya Pérez, Mª Soledad García & Joaquín A. Ortuño

Authors
  1. María Cuartero
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  2. Soraya Pérez
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  3. Mª Soledad García
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  4. Joaquín A. Ortuño
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Corresponding author

Correspondence to Joaquín A. Ortuño.

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Cuartero, M., Pérez, S., García, M.S. et al. Ion-selective electrodes for the determination of l-carnitine. Application in dissolution testing of a dietary supplement. Monatsh Chem 145, 1879–1885 (2014). https://doi.org/10.1007/s00706-014-1316-4

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  • DOI: https://doi.org/10.1007/s00706-014-1316-4

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