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Application of a trazodone-selective electrode to pharmaceutical quality control and urine analyses

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Abstract

A trazodone-selective electrode for application in pharmaceutical quality control and urine analysis was developed. The electrode is based on incorporation of a trazodone-tetraphenylborate ion exchanger in a poly(vinyl chloride) membrane. The electrode showed a fast, stable and Nernstian response over a wide trazodone concentration range (5 × 10−5−1 × 10−2 M) with a mean slope of 59.3 ± 0.9 mV/dec of concentration, a mean detection limit of 1.8 × 10−5 ± 2.2 × 10−6 M, a wide working pH range (5–7.5) and a fast response time (less than 20 s). The electrode also showed good accuracy, repeatability, reproducibility and selectivity with respect to some inorganic and organic compounds, including the main trazodone metabolite. The electrode provided good analytical results in the determination of trazodone in pharmaceuticals and spiked urine samples; no extraction steps were necessary. Dissolution testing of trazodone tablets, in different conditions of pH and particle size, based on a direct potentiometric determination with the new selective electrode is presented as well.

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Acknowledgements

We gratefully acknowledge the Ministerio de Ciencia y Tecnología, Spain (project CTQ 2005-06977/BQU), and FEDER (Fondo Europeo de Desarrollo Regional) for financial support of this work.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071, Murcia, Spain

    M. Soledad García, Joaquín Ortuño, M. Isabel Albero & María Cuartero

Authors
  1. M. Soledad García
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  2. Joaquín Ortuño
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  3. M. Isabel Albero
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  4. María Cuartero
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Corresponding author

Correspondence to M. Soledad García.

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García, M.S., Ortuño, J., Albero, M.I. et al. Application of a trazodone-selective electrode to pharmaceutical quality control and urine analyses. Anal Bioanal Chem 394, 1563–1567 (2009). https://doi.org/10.1007/s00216-009-2699-7

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  • DOI: https://doi.org/10.1007/s00216-009-2699-7

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