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Angiotensin II and dengue

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Abstract

Dengue is a disease caused by a flavivirus that is transmitted principally by the bite of an Aedes aegypti mosquito and represents a major public-health problem. Many studies have been carried out to identify soluble factors that are involved in the pathogenesis of this infection. Cytokines, soluble factors, and oxidative stress have been reported to be involved in the development of severe disease. Angiotensin II (Ang II) is a hormone with the ability to induce the production of cytokines and soluble factors related to the inflammatory processes and coagulation disorders observed in dengue. However, a direct involvement of Ang II in this disease has not been demonstrated. This review primarily summarizes the pathophysiology of dengue, the role of Ang II in various diseases, and reports that are highly suggestive of the involvement of this hormone in dengue.

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Acknowledgements:

We thank Instituto de Investigaciones Clínicas Dr. Américo Negrette, Facultad de Medicina, Universidad de Zulia, Maracaibo, Venezuela.

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This study did not receive any financial support.

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Authors and Affiliations

  1. Instituto de Investigaciones Clínicas “Dr. Américo Negrette”, Facultad de Medicina, Universidad del Zulia, Maracaibo, 4001-A, Venezuela

    Jesus A Mosquera-Sulbaran & Juan Pablo Hernandez-Fonseca

  2. Cátedra de Inmunología, Escuela de Bioanálisis, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela

    Adriana Pedreañez

  3. Servicio de Microscopia Electronica del Centro Nacional de Biotecnologia (CNB- CSIC) Madrid, Madrid, España

    Juan Pablo Hernandez-Fonseca

  4. Department of Anatomy, Physiology and Pharmacology, School of Veterinary Medicine, Saint George’s University, True Blue, West Indies, Grenada

    Hugo Hernandez-Fonseca

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  1. Jesus A Mosquera-Sulbaran
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  3. Juan Pablo Hernandez-Fonseca
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  4. Hugo Hernandez-Fonseca
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Contributions

JM-S and AP conceived the subject matter and contributed to the design of the work. JM-S, AP, JPH-F, and HH-F contributed to the acquisition, analysis, or interpretation of data for the work. JM-S and AP wrote the original draft. JM-S, AP, JPH-F, and HH-F critically revised the first draft. All authors approved the final version for all aspects of the work, ensuring integrity and accuracy.

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Correspondence to Jesus A Mosquera-Sulbaran.

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Mosquera-Sulbaran, J.A., Pedreañez, A., Hernandez-Fonseca, J.P. et al. Angiotensin II and dengue. Arch Virol 168, 191 (2023). https://doi.org/10.1007/s00705-023-05814-6

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