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Molecular analysis of goose parvovirus field strains from a Derzsy’s disease outbreak reveals local European-associated variants

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Abstract

Since its first recognition in the early 1960s, Derzsy’s disease has caused significant economic losses in the goose meat industry through the world. Today, Derzsy’s disease still maintains its importance for small-scale waterfowl farming, despite not having a significant impact on public health. In the present study, we investigated the distribution of goose parvovirus (GPV) and its potential variants from a 2019 outbreak in Turkey. Tissue samples were obtained from infected eggs and goslings that were raised in distinct farming areas of the various provinces. For this purpose, a novel primer set for amplification of a 630-bp region of VP3 was designed to confirm GPV infection by conventional PCR method. A 4709-base nucleotide sequence including the structural, non-structural, and 5' inverted terminal repeat regions was obtained from three samples from the Central Anatolian region. Multiple sequence comparisons and phylogenetic analysis demonstrated that the field strains clustered with European group 2 and contained a series of unique amino acid substitutions that might affect the virulence of the virus. These results confirmed that European-related field strains caused the outbreak in Asia Minor, and this might assist in understanding the circulation of GPV in Asia and Europe.

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Abbreviations

BLAST:

Basic Local Alignment Search Tool

dN:

Non-synonymous mutation

dS:

Synonymous mutation

GPV:

Goose parvovirus

ITR:

Inverted terminal repeat

MDPV:

Muscovy duck parvovirus

MUSCLE:

Multiple Sequence Comparison by Log-Expectation

MSA:

Multiple sequence alignment

NS:

Non-structural

PCR:

Polymerase chain reaction

Rep:

Replication

RBE:

Ribosome binding element

SBDS:

Short beak and dwarfism syndrome

USA:

United States of America

VP:

Viral protein

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Acknowledgements

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Authors and Affiliations

  1. Department of Virology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, 58140, Sivas, Turkey

    Hakan Isidan, Turhan Turan & Mustafa Ozan Atasoy

  2. Department of Internal Medicine, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, 58140, Sivas, Turkey

    Alparslan Coskun

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  1. Hakan Isidan
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  2. Turhan Turan
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Correspondence to Turhan Turan.

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Isidan, H., Turan, T., Atasoy, M.O. et al. Molecular analysis of goose parvovirus field strains from a Derzsy’s disease outbreak reveals local European-associated variants. Arch Virol 166, 1931–1942 (2021). https://doi.org/10.1007/s00705-021-05086-y

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