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Advances in the use of functional composites of β-cyclodextrin in electrochemical sensors

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Abstract

β-Cyclodextrin (β-CD) possess a hydrophobic inner cavity and a hydrophilic exterior surface. They exhibit excellent inclusion properties with the guest molecules that match cavity size, and β-CD-based materials drew widespread attention in electrochemical sensors. The hydroxy groups at the edge of the cavity can form hydrogen bonds and undergo electrostatic and dipole-dipole interactions with other molecules. This review (with 109 refs.) reveals β-CD-based detection mechanisms from the viewpoint of the size/shape-fit concept, and summarizes the current state of multiple electrochemical sensors based on the use of β-CD and functionalized β-CD such as carboxymethyl-β-CD, mono-(6-ethanediamine-6-deoxy)-β-CD, hydroxypropyl-β-CD, thio-β-cyclodextrin, and others.

Schematic diagram of cyclodextrin inclusion complex formation in aqueous solution, represents water molecules, represents guest molecule.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (51262027), the financial support of the State Key Laboratory of Solidification Processing in NWPU (SKLSP201754), the Science and Technology Project Gansu Province (17YF1GA017), the Research Project of Higher Education in Gansu Province (2017A-002) and the Science and Technology Project Gansu Province (17JR5RA082).

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  1. Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education of China, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People’s Republic of China

    Xiaohui Niu, Zunli Mo, Xing Yang, Mingyuan Sun, Pan Zhao, Zhenliang Li, Meixuan Ouyang, Zhenyu Liu, Huhu Gao, Ruibin Guo & Nijuan Liu

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  1. Xiaohui Niu
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  2. Zunli Mo
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  3. Xing Yang
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  4. Mingyuan Sun
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  5. Pan Zhao
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  6. Zhenliang Li
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  7. Meixuan Ouyang
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  8. Zhenyu Liu
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  9. Huhu Gao
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  11. Nijuan Liu
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Correspondence to Zunli Mo.

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Niu, X., Mo, Z., Yang, X. et al. Advances in the use of functional composites of β-cyclodextrin in electrochemical sensors. Microchim Acta 185, 328 (2018). https://doi.org/10.1007/s00604-018-2859-6

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