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Immunomodulatory macrophages and Treg in pulmonary hypertension

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Abstract

Pulmonary hypertension (PH) is a disease that affects the right ventricle and venous circulation. The need for improvement in the discovery of novel therapeutic targets and drugs focusing on the immunomodulatory for the treatment of pulmonary hypertension is very important. Abnormalities in the immune system may result in pulmonary hypertension, and macrophages and Treg may be important targets for the development of novel treatment of pulmonary hypertension. Certainly, the macrophages, Treg, and the immune system have the potential therapeutic benefit by effectively modulating the macrophage to benefit pro-resolving phenotype anti-inflammatory and repair. The multifaceted association of immune system homeostasis, macrophages, and Treg is still debatable. Here, in this review, we highlight the significance of macrophages, Treg, and other immune cells’ functions in pulmonary hypertension. We also considered the Treg and macrophages in the phosphatidyl inositol 3-kinase signaling pathway.

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  1. Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China

    Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin & Xaioju Zhang

  2. Department of Natural and Environmental Science, American University of Nigeria, Yola, Adamawa, Nigeria

    Ayobami Matthew Olajuyin & Adefunke Kafayat Olajuyin

  3. Department of Pathophysiology, School of Basic Medical Science, Huazhong University of Science and Technology Hanhou, Wuhan, China

    Qinghua Hu

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Olajuyin, A.M., Olajuyin, A.K., Zhang, X. et al. Immunomodulatory macrophages and Treg in pulmonary hypertension. Comp Clin Pathol 33, 163–173 (2024). https://doi.org/10.1007/s00580-023-03540-8

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