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Amplitude at 10 min in thromboelastography predicts maximum amplitude: a single-center observational study

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Abstract

Thromboelastography is a quantitative test widely used to measure the efficiency of blood clotting. However, awaiting the results of maximum amplitude (MA) is necessary for determining the need for platelet- and fibrinogen-containing products. A more rapid prediction of MA could facilitate faster preparation and administration of blood transfusion products, thereby resulting in coagulation improvement. In this retrospective study, we hypothesized that early amplitude at 10 min (A10) could be a predictor of MA. Therefore, we investigated whether MA can be rapidly inferred from thromboelastographic 6 s (TEG6s) measurements and evaluated its correlation with A10. We extracted TEG6s measurements obtained in operating rooms and intensive care units of our hospital between January 2018 and December 2022. The correlation of MA with display items of TEG6s results, including reaction time, kinetics, α angle, activated clotting time, and A10, was evaluated. The relationship between citrated rapid TEG (CRT)-A10 and CRT-MA, as well as between citrated functional fibrinogen (CFF)-A10 and CFF-MA, were evaluated if A10 and MA showed a good correlation. The results showed good correlations between CRT-A10 and CRT-MA, as well as between CFF-A10 and CFF-MA. Therefore, evaluating A10 using TEG6s could predict MA.

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Fig. 1

Data availability

The data that support the findings of this study are available on request from the corresponding author.

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Acknowledgements

We thank all the anesthesiology medical staff at Nagoya University Hospital for their assistance with this study.

Funding

This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Anesthesiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Takahiro Tamura & Kimitoshi Nishiwaki

  2. Department of Perioperative Management System, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Tatsuro Yokoyama

Authors
  1. Takahiro Tamura
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  2. Tatsuro Yokoyama
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  3. Kimitoshi Nishiwaki
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Contributions

Conceptualization: TT; methodology: TT, KN; formal analysis: TT, TY, KN; data curation: TT; writing—original draft: TT; writing—review and editing: TT, TY, KN.

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Correspondence to Takahiro Tamura.

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Takahiro Tamura, Tatsuro Yokoyama, and Kimitoshi Nishiwaki have no conflict of interest.

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Tamura, T., Yokoyama, T. & Nishiwaki, K. Amplitude at 10 min in thromboelastography predicts maximum amplitude: a single-center observational study. J Anesth 38, 136–140 (2024). https://doi.org/10.1007/s00540-023-03301-5

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  • DOI: https://doi.org/10.1007/s00540-023-03301-5

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