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Oxidative stress and insulin resistance in policemen working shifts

  • Original Article
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International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

Abstract

Purpose

Shift work is a work schedule involving irregular or unusual hours, compared to those of a normal daytime work schedule. In developed countries, night shift work is very common. In several cities of our country, 12/24 shift system is implemented in police organization. While night shift work composes half of the 20 shift in a month, in ergonomic shift system, an alternative shift schedule, shift work can be performed in three shifts in a day. In this study, we aimed to investigate the effects of 12/24 shift work system on insulin resistance and oxidative stress and systemic inflammation.

Methods

Two hundred and four 12/24 shift workers (age 44.3 ± 5.6 years) and 193 ergonomic shift workers (age 42.6 ± 5.5 years) were included to study. Serum oxidized LDL (ox-LDL), neutrophil gelatinase lipocalin-2 (NGAL) as oxidative stress markers, glucose, insulin, ferritin, high-sensitive C-reactive protein (hsCRP) and erythrocyte sedimentation rate values were measured. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated to evaluate insulin resistance.

Results

Serum ox-LDL, HOMA-IR, hsCRP and NGAL levels in 12/24 shift system were found to be significantly higher compared with ergonomic shift workers (p < 0.0001, p = 0.02, p = 0.03, p = 0.02, respectively). When evaluated all subjects, weak but significant correlation was found between HOMA-IR with ox-LDL (r = 0.12, p = 0.01), hsCRP (r = 0.17, p = 0.001) and ferritin (r = 0.15, r = 0.003). Also in 12/24 shift work group, there were significant correlations between HOMA-IR with hsCRP (r = 0.17, p = 0.01) and ferritin (r = 0.25, p = 0.0001).

Conclusion

It may be concluded that 12/24 shift system might give rise to insulin resistance and oxidative stress. Additionally, workers in this system may under risk of systemic inflammatory response. Working hours must be arranged in accordance with the physiological rhythm.

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References

  • Bahceci M, Tuzcu A, Ogun C, Canoruc N, Iltimur K, Aslan C (2005) Is serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease? J Endocrinol Invest 28(2):145–150

    Article  CAS  Google Scholar 

  • Biggi N, Consonni D, Galluzzo V, Sogliani M, Costa G (2008) Metabolic syndrome in permanent night workers. Chronobiol Int 25(2):443–454

    Article  Google Scholar 

  • Bolignano D, Coppolino G, Donato V, Lacquaniti A, Bono C, Buemi M (2010) Neutrophil gelatinase-associated lipocalin (NGAL): a new piece of the anemia puzzle? Med Sci Monit 16(6):131–135

    Google Scholar 

  • Bonfils L, Ellervik C, Friedrich N, Linneberg A, Sandholt CH, Jørgensen ME, Jørgensen T, Hansen T, Pedersen O, Allin KH (2015) Fasting serum levels of ferritin are associated with impaired pancreatic beta cell function and decreased insulin sensitivity: a population-based study. Diabetologia 58(3):523–533

    Article  CAS  Google Scholar 

  • Charles LE, Burchfiel CM, Fekedulegn D, Vila B, Hartley TA, Slaven J, Mnatsakanova A, Violanti JM (2007) Shift work and sleep: the Buffalo police health study. Polic Int J Police Strateg Manag 30:215–227

    Article  Google Scholar 

  • Costa G, Haus E, Stevens R (2010) Shift work and cancer considerations on rationale, mechanisms, and epidemiology. Scand J Work Environ Health 36(2):163–179

    Article  Google Scholar 

  • Coventry BJ, Ashdown ML, Quinn MA, Markovic SN, YatomiClarke SL, Robinson AP (2009) CRP identifies homeostatic immune oscillations in cancer patients: a potential treatment targeting tool? J Transl Med 7:102

    Article  Google Scholar 

  • De Bacquer D, Van Risseghem M, Clays E, Kittel F, De Backer G, Braeckman L (2009) Rotating shift work and the metabolic syndrome: a prospective study. Int J Epidemiol 38(3):848–854

    Article  Google Scholar 

  • Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H (2003) Role of oxidative stress in atherosclerosis. Am J Cardiol 6(91):7A–11A

    Article  Google Scholar 

  • Holvoet P, Mertens A, Vehamme P, Boagerts K, Beyens G, Verhaeghe R, Collen D, Muls E (2001) Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler Thromb Vasc Biol 21:844–848

    Article  CAS  Google Scholar 

  • Kafkas N, Demponeras C, Zoubouloglou F, Spanou L, Babalis D, Makris K (2012) Serum levels of gelatinase associated lipocalin as indicator of the inflammatory status in coronary artery disease. Int J Inflamm 2012:189797

    Article  Google Scholar 

  • Karlsson B, Alfredsson L, Knutsson A, Andersson E, Torén K (2005) Total mortality and cause-specific mortality of Swedish shift- and dayworkers in the pulp and paper industry in 1952–2001. Scand J Work Environ Health 31(1):30–35

    Article  Google Scholar 

  • Khreiss T, Jozsef L, Potempa LA, Filep JG (2004) Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells. Circulation 109(16):2016–2022

    Article  CAS  Google Scholar 

  • Killgore WDS, Kahn-Greene ET, Lipizzi EL, Newman RA, Kamimori GH, Balkin TJ (2008) Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. Sleep Med 9:517–526

    Article  Google Scholar 

  • Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268:10425–10432

    CAS  Google Scholar 

  • Knutsson A (2003) Health disorders of shift workers. Occup Med (Lond) 53(2):103–108

    Article  Google Scholar 

  • Kudielka BM, Buchtal J, Uhde A, Wüst S (2007) Circadian cortisol profiles and psychological self-reports in shift workers with and without recent change in the shift rotation system. Biol Psychol 74(1):92–103

    Article  Google Scholar 

  • Kushner I, Samols D, Magrey M (2010) A unifying biologic explanation for “high-sensitivity” C-reactive protein and “low-grade” inflammation. Arthritis Care Res (Hoboken) 62(4):442–446

    Article  CAS  Google Scholar 

  • Lauren B, Waggoner MA, Devon A, Grant MS, Hans PA, Van Dongen PhD, Gregory Belenky MD, Vila Bryan (2012) A combined field and laboratory design for assessing the impact of night shift work on police officer operational performance. Sleep 35:111575–111577

    Google Scholar 

  • Lee S, Choe JW, Kim HK, Sung J (2011) High-sensitivity C-reactive protein and cancer. J Epidemiol 21(16):1–8

    Google Scholar 

  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419

    Article  CAS  Google Scholar 

  • McMenamin TM (2007) A time to work: recent trends in shift work and flexible schedules. Mon Labor Rev 130:3–15

    Google Scholar 

  • Meisinger C, Baumert J, Khuseyinova N, Loewel H, Koenig W (2005) Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation 112:651–657

    Article  CAS  Google Scholar 

  • Musunuru K, Kral BG, Blumenthal RS, Fuster V, Campbell CY, Gluckman TJ, Lange RA, Topol EJ, Willerson JT, Desai MY, Davidson MH, Mora S (2008) The use of high-sensitivity assays for C-reactive protein in clinical practice. Nat Clin Pract Cardiovasc Med 5(10):621–635

    Article  CAS  Google Scholar 

  • Nagaya T, Yoshida H, Takahashi H, Kawai M (2002) Markers of insulin resistance in day and shift workers aged 30–59 years. Int Arch Occup Environ Health 75:562–568

    Article  CAS  Google Scholar 

  • Padilha HG, Crispim CA, Zimberg IZ, Folkard S, Tufik S, de Mello MT (2010) Metabolic responses on the early shift. Chronobiol Int 27(5):1080–1092

    Article  CAS  Google Scholar 

  • Parent-Thirion A, Fernández Macías E, Hurley J, Vermeylen G (2007) Fourth European Working Conditions Survey. Dublin, European Foundation for the Improvement of Living and Working Conditions

  • Puttonen S, Härmä M, Hublin C (2010) Shift work and cardiovascular disease—pathways from circadian stress to morbidity. Scand J Work Environ Health 36(2):96–108

    Article  Google Scholar 

  • Rajaratnam SM, Barger LK, Lockley SW, Shea SA, Wang W, Landrigan CP, O’Brien CS, Qadri S, Sullivan JP, Cade BE, Epstein LJ, White DP, Czeisler CA (2011) Sleep disorders, health, and safety in police officers. JAMA 306:2567–2578

    Article  CAS  Google Scholar 

  • Roudkenar MH, Kuwahara Y, Baba T, Roushandeh AM, Ebishima S, Abe S, Ohkubo Y, Fukumoto M (2007) Oxidative stress induced lipocalin 2 gene expression: addressing its expression under the harmful conditions. J Radiat Res 48:39–44

    Article  CAS  Google Scholar 

  • Roudkenar MH, Halabian R, Ghasemipour Z, Roushandeh AM, Rouhbakhsh M, Nekogoftar M, Kuwahara Y, Fukumoto M, Shokrgozar MA (2008) Neutrophil gelatinase-associated lipocalin acts as a protective factor against H(2)O(2) toxicity. Arch Med Res 39:560–566

    Article  CAS  Google Scholar 

  • Roudkenar MH, Halabian R, Bahmani P, Roushandeh AM, Kuwahara Y, Fukumoto M (2011) Neutrophil gelatinase-associated lipocalin: a new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. Free Radic Res 45(7):810–819

    Article  CAS  Google Scholar 

  • Schernhammer E, Schulmeister K (2004) Light at night and cancer risk. Photochem Photobiol 79(4):316–318

    Article  CAS  Google Scholar 

  • Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Altieri A, Benbrahim-Tallaa L, Cogliano V (2007) Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol 8(12):1065–1066

    Article  Google Scholar 

  • Violanti JM, Fekedulegn D, Andrew ME, Charles LE, Hartley TA, Vila B, Burchfiel CM (2013) Shift work and long-term injury among police officers. Scand J Work Environ Health 39(4):361–368

    Article  Google Scholar 

  • Vyas MV, Garg AX, Iansavichus AV, Costella J, Donner A, Laugsand LE, Janszky I, Mrkobrada M, Parraga G, Hackam DG (2012) Shift work and vascular events: systematic review and meta-analysis. BMJ 26(345):e4800

    Article  Google Scholar 

  • Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A (2007) Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 53:34–41

    Article  CAS  Google Scholar 

  • Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED (2007) The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 56:2533–2540

    Article  CAS  Google Scholar 

  • Zografos T, Haliassos A, Korovesis S, Giazitzoglou E, Voridis E, Katritsis D (2009) Association of neutrophil gelatinase-associated lipocalin with the severity of coronary artery disease. Am J Cardiol 104(7):917–920

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This study was financially supported by a research fund from the Scientific and Technological Research Council of Turkey (TUBITAK) (112S559).

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Authors and Affiliations

  1. Balıkesir Police Department, Balıkesir, Turkey

    Irfan Demir

  2. Department of Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey

    Aysun Toker

  3. Gaziantep Police Department, Gaziantep, Turkey

    Selcuk Zengin

  4. Department of Biochemistry, Medical Faculty, Ataturk University, Erzurum, Turkey

    Esra Laloglu & Hulya Aksoy

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  1. Irfan Demir
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  2. Aysun Toker
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  3. Selcuk Zengin
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Correspondence to Aysun Toker.

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Demir, I., Toker, A., Zengin, S. et al. Oxidative stress and insulin resistance in policemen working shifts. Int Arch Occup Environ Health 89, 407–412 (2016). https://doi.org/10.1007/s00420-015-1079-1

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