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Association of lens density quantified by IOLMaster 700 with lenticular myopia in nuclear cataract

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Abstract 

Purpose

To explore the associated ocular parameters with lenticular myopia and assess the correlation between lens density and myopic shift.

Methods

This retrospective cross-sectional study enrolled 50 patients with lenticular high myopia as the study group and 85 cases as the validation group. Lens density was obtained through swept-source optical coherence tomography (SS-OCT, IOLMaster 700) and measured by Image J software. Linear regression analysis and correlation analysis were applied to study the association between lenticular myopia and ocular variables. Receiver operating characteristic curves and calibration charts were plotted for nuclear density (ND) in identifying lenticular high myopia.

Results

Both ND and lens thickness were discovered to be associated with spherical equivalent refraction and lens power (p < 0.05); yet, only ND was significantly correlated with lenticular myopia, as the difference of nuclear density (NDdiff) between the lenticular myopic eye and the fellow eye was significantly correlated with the interocular difference of spherical equivalent refraction (SERdiff, r =  − 0.752, p < 0.001) and the interocular difference of lens power (LPdiff, r = 0.834, p < 0.001). The ND is a good metric for diagnosing lenticular high myopia, with the area under curve (AUC) being 0.898 (0.821–0.949) and the cut-off value being 98.88 pixel units. The accuracy of the cut-off value in the validation group was 82.35%.

Conclusions

Average ND quantified by IOLMaster 700 is not only associated with lenticular myopia but is a suitable metric for predicting the amount of myopic shift.

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Funding

This research was funded by Jiangsu Provincial Medical Innovation Team, grant number CXTDA2017039.

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Authors and Affiliations

  1. Department of Ophthalmology, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China

    Lijun Wang, Chen Li, Jianqing Li, Zhigang Chen, Weiming Liu & Peirong Lu

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  1. Lijun Wang
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  2. Chen Li
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  3. Jianqing Li
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Correspondence to Peirong Lu.

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This retrospective cross-sectional study was approved by the ethics committee of the First Affiliated Hospital of Soochow University and conducted in compliance with the Declaration of Helsinki.

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This type of study does not require informed consent.

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Wang, L., Li, C., Li, J. et al. Association of lens density quantified by IOLMaster 700 with lenticular myopia in nuclear cataract. Graefes Arch Clin Exp Ophthalmol 260, 1565–1572 (2022). https://doi.org/10.1007/s00417-021-05495-4

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  • DOI: https://doi.org/10.1007/s00417-021-05495-4

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