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Changing trends in rheumatoid arthritis mortality in Mexico, from 1998 to 2017

  • Epidemiology of RMD
  • Published:
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Abstract

The aim was to analyze the distribution and trends of deaths reported for rheumatoid arthritis (RA) in Mexico in 1998–2017. We carried out a cross-sectional study. Data were obtained from Dynamic Cubes, General Direction of Health Information, on deaths related to RA in Mexico. Seropositive RA was diagnosed using the International Classification of Diseases version 10. Variables were categorized by diagnosis, age, and gender. Time trends of age-standardized mortality rates (ASMRs) were analyzed for RA, and the annual percent change (APC) was estimated using Joinpoint trend analysis. We found 714 deaths mentioned as RA and 9,749,956 non-RA deaths between 1998 and 2017. Overall RA mortality decreased from 0.14 in 2004 to 0.04 per 100 000 in 2017 (APC: − 10.3%; 95% CI − 16.5%, − 3.3%), while the non-RA ASMR remained stable. In females, there was an initial increase of 27.3% per year through 1998–2004 and a reduction of − 11.7% per year subsequently, while in males, the APC remained stable between 1998 and 2017. The trend for RA mortality resulted in a cumulative change in the ratio of RA ASMR to non-RA ASMR of − 20.6% in females and + 3.2% in males. Although mortality attributable to RA increased from 1998 to 2004 in Mexico, it began to improve after 2004, particularly in females. Prospective, population-based data could help to identify risk factors that could be altered to improve outcomes.

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Data availability

The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank David Buss for technical assistance.

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None.

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Authors and Affiliations

  1. Department of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, México

    Ivet Morales-Etchegaray, Mario Garcia-Carrasco, Pamela Munguía-Realpozo, Claudia Mendoza-Pinto, Olivia Navarro-Milán & Sandra Karina Velez-Pelcastre

  2. Systemic Autoimmune Diseases Research Unit, Specialties Hospital UMAE, Mexican Social Security Institute, Puebla, México

    Claudia Mendoza-Pinto

  3. Research in Health Coordination, Mexican Social Security Institute, Puebla, México

    Socorro Méndez-Martínez

  4. Division of Musculoskeletal and Rheumatic Disorders, National Rehabilitation Institute Luis Guillermo Ibarra Ibarra, Mexico City, Mexico

    Carlos Javier Pineda-Villaseñor

Authors
  1. Ivet Morales-Etchegaray
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Contributions

IEM, MGC, PMR and CMP analyzed and interpreted the data. They were the major contributors in writing the manuscript. SMM and ONM and SKVP contributed to data acquisition. CPV helped in interpretation of the data and revision of the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Claudia Mendoza-Pinto.

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Morales-Etchegaray, I., Garcia-Carrasco, M., Munguía-Realpozo, P. et al. Changing trends in rheumatoid arthritis mortality in Mexico, from 1998 to 2017. Rheumatol Int 41, 2225–2231 (2021). https://doi.org/10.1007/s00296-021-05013-z

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