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Tuning gelatin–alginate bioink properties by introducing new decellularized elastic cartilage scaffolds for bioinspired composite membranes in orthopedics

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Abstract

Three-dimensional bioprinting enables the generation of precisely controlled 3D cell models and tissue constructs by engineering anatomically shaped substrates with tissue-like complexity. Due to the high degree of control on structure and composition, 3D bioprinting has the potential to satisfy many critical needs in medical applications, including applications in cosmetics testing, regenerative medicine, and functional organ replacement. In this study, a series of new crosslinked polymeric porous bioinspired composite membranes containing decellularized elastic cartilage scaffold(dECS) would be designed and prepared from porcine elastic cartilage by using supercritical carbon dioxide fluid for 3D bioink and 3D bioprinting materials. Effect of crosslinking functionality on microstructures and thermal properties of new polymeric porous bioinspired composite membranes containing dECS would be further studied. This work would provide a simple and time-saving method process for the preparation of polymeric porous composite membranes containing dECS, which were further characterized by Fourier transform infrared spectroscopy, thermal properties, morphology, mechanical properties, and hemocompatibility.

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Acknowledgements

Authors would like to acknowledge the Taiwan PARSD Pharmaceutical Technology Consultants Ltd Company for financial and technical support. The authors also thank for technical assistances of Ko-Yu Hsu and Yu-Hung Lu.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Ming-Chuan University, Taoyuan city, Taiwan

    Ching-Cheng Huang

  2. PARSD Biomedical Material Research Center, Taichung city, Taiwan

    Ching-Cheng Huang

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  1. Ching-Cheng Huang
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Correspondence to Ching-Cheng Huang.

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Huang, CC. Tuning gelatin–alginate bioink properties by introducing new decellularized elastic cartilage scaffolds for bioinspired composite membranes in orthopedics. Polym. Bull. 80, 3279–3291 (2023). https://doi.org/10.1007/s00289-022-04211-4

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  • DOI: https://doi.org/10.1007/s00289-022-04211-4

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