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Gd-EOB-DTPA enhanced MRI based radiomics combined with clinical variables in stratifying hepatic functional reserve in HBV infected patients

  • Hepatobiliary
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Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purposes

To evaluate radiomics from Gd-EOB-DTPA enhanced MR combined with clinical variables for stratifying hepatic functional reserve in hepatitis B virus (HBV) patients.

Methods

Our study included 279 chronic HBV patients divided 8:2 for training and test cohorts. Radiomics features were extracted from the hepatobiliary phase (HBP) MR images. Radiomics features were selected to construct a Rad-score which was combined with clinical parameters in two models differentiating hepatitis vs. Child–Pugh A and Child–Pugh A vs. B/C. Performances of these stratifying models were compared using area under curve (AUC).

Results

Rad-score alone discriminated hepatitis vs. Child–Pugh A with AUC = 0.890, 0.914 and Child–Pugh A vs. B/C with AUC = 0.862, 0.865 for the training and test cohorts, respectively. Model 1 [Rad-score + clinical parameters for hepatitis vs. Child–Pugh A] showed AUC = 0.978 for the test cohort, which was higher than ALBI [albumin-bilirubin] and MELD [model for end-stage liver disease], with AUCs of 0.716, 0.799, respectively (p < 0.001, < 0.001). Model 2 [Rad-score + clinical parameters for Child–Pugh A vs. B/C] showed AUC of 0.890 in the test cohort, which was similar to ALBI (AUC = 0.908, p = 0.760), and higher than MELD (AUC = 0.709, p = 0.018).

Conclusion

Rad-score combined with clinical variables stratifies hepatic functional reserve in HBV patients.

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Funding

This study was funded by Jiangsu Province “333” project from Jiangsu Province Human Resources and Social Security Department (2022-3-6-139).

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Authors and Affiliations

  1. Department of Radiology, Northern Jiangsu People’s Hospital, Clinical Medical College, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, China

    Jinghui Hu, Xiaoxiao Wang, Jun Sun, Xin Yang, Wenjian Wang, Jing Ye & Xianfu Luo

  2. Department of Radiology, Weill Medical College of Cornell University, 407 E61st Street, New York, NY, 10065, USA

    Martin Prince

  3. Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Yunjin Road 701, Xuhui District, Shanghai, 200232, China

    Fang Wang & Lei Chen

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  1. Jinghui Hu
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Correspondence to Xianfu Luo.

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Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Northern Jiangsu People’s Hospital, Clinical Medical School of Yangzhou University (2023JS051).

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Hu, J., Wang, X., Prince, M. et al. Gd-EOB-DTPA enhanced MRI based radiomics combined with clinical variables in stratifying hepatic functional reserve in HBV infected patients. Abdom Radiol 49, 1051–1062 (2024). https://doi.org/10.1007/s00261-023-04176-6

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