Abstract
A microsatellite has previously been identified in myostatin in cattle. Sequencing of this region from other artiodactyls coupled with phylogenetic analysis has been used to uncover the potential origins of the microsatellite event, which appears either to have been born twice or to have been gained and lost within ruminants. While caprids and ovids share the ancestral state with pigs and other mammals, microsatellite activity (length polymorphism) is uncovered in both deer and bovids. The dynamic process of microsatellite evolution, including birth, is discussed here in light of several models. Finally, these models are evaluated in the context of patterns of microsatellite conservation between closely related mammalian genomes.
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Acknowledgments
We thank Katharina Dittmar and Dietric Hennings for help with obtaining samples and with sequencing. We are grateful to Martin Kreitman, Alex Buerkle, and two anonymous reviewers for helpful discussions. We thank the Center for the Reproduction of Endangered Species at the San Diego Zoo, Kim Sargeant at the Wyoming Fish and Game Wildlife Forensics Laboratory, The Field Museum, University of Alaska-Fairbanks Museum of the North, El Mañana Serengueti, Alfonso Ortega, Alejandro Sánchez, Ing Raul Cabrera, Victoria Garza, Manuel Parra, and the Tamatan Zoo for providing us with some DNA samples. In particular, the whale sample is sample no. UAM24066 from the mammal collection of the University of Alaska-Fairbanks Museum of the North, on loan to Katharina Dittmar of the Liberles Lab. This sample was collected on August 18, 1992, in Nazan Bay, Village of Atka, by Patrick B. Holmes, Moses L. Dirks, and Sylvia Brunner. This work was funded by FUGE, the Norwegian Functional Genomics Research Council, INBRE, and University of Wyoming startup funds to David Liberles.
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Tellgren-Roth, Å., Kolesov, G., Sifuentes-Rincón, A.M. et al. Complex Microsatellite Dynamics in the Myostatin Gene Within Ruminants. J Mol Evol 66, 258–265 (2008). https://doi.org/10.1007/s00239-008-9080-x
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DOI: https://doi.org/10.1007/s00239-008-9080-x