Skip to main content

Advertisement

SpringerLink
Log in

The role and management of vitamin supplementation in plastic surgery patients: A comprehensive review

  • Review
  • Published:
European Journal of Plastic Surgery Aims and scope Submit manuscript

Abstract

After reading this article about all the common essential vitamins, the participant should be able to (1) Explain their biological function and surgical relevance, (2) describe the clinical manifestations of deficiency and toxicity, and (3) provide general guidance regarding vitamins to plastic surgery patients in the perioperative setting.

Vitamin deficiencies and toxicity can predispose patients to surgical complications and poor wound healing. Furthermore, vitamin supplement consumption among the general population has been increasing over time, providing the plastic surgeon the added responsibility to be informed about the interactions and effects of vitamins in the context of surgery.

Literature on all common essential vitamins was reviewed and summarized to include biological functions, surgical relevance, and effects of deficiency and toxicity. Scientific evidence was used to collate advice to plastic surgeons regarding vitamin management in the perioperative setting.

Most vitamins aid with wound healing. Screening and supplementation for specific vitamins can be considered based on patient characteristics, nutritional and medical history, and history of bariatric surgery. Vitamin E should be stopped two weeks prior to surgery due to increased bleeding risk.

The plastic surgeon should encourage open discussions with patients to learn about which vitamin supplements they take and whether they are at risk for deficiency or toxicity. This is the first comprehensive review to discuss and provide guidance about all common essential vitamins (A, B1, B2, B3, B5, B6, B7, B9, B12, C, D, E, and K) in the context of plastic surgery.

Level of evidence 

Not ratable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Millen AE, Dodd KW, Subar AF (2004) Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: the 1987, 1992, and 2000 National Health Interview Survey results. J Am Diet Assoc 104(6):942–950

    Article  PubMed  Google Scholar 

  2. Rock CL (2007) Multivitamin-multimineral supplements: who uses them? Am J Clin Nutr 85(1):277S–279S

    Article  PubMed  CAS  Google Scholar 

  3. Mishra S, Ogden C, Dimeler M, Potischman N. Dietary supplement use in the United States: National Health and Nutrition Examination Survey, 2017–March 2020. 2023

  4. Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, Delbanco TL (1993) Unconventional medicine in the United States. Prevalence, costs, and patterns of use. N Engl J Med 328(4):246–252

    Article  PubMed  CAS  Google Scholar 

  5. Williams DGA, Molinger J, Wischmeyer PE (2019) The malnourished surgery patient: a silent epidemic in perioperative outcomes? Curr Opin Anaesthesiol 32(3):405–411

    Article  PubMed  PubMed Central  Google Scholar 

  6. Schiesser M, Kirchhoff P, Müller MK, Schäfer M, Clavien PA (2009) The correlation of nutrition risk index, nutrition risk score, and bioimpedance analysis with postoperative complications in patients undergoing gastrointestinal surgery. Surgery 145(5):519–526

    Article  PubMed  Google Scholar 

  7. Allard JP, Keller H, Jeejeebhoy KN et al (2016) Malnutrition at hospital admission-contributors and effect on length of stay: a prospective cohort study from the Canadian Malnutrition Task Force. JPEN J Parenter Enteral Nutr 40(4):487–497

    Article  PubMed  Google Scholar 

  8. Correia MI, Waitzberg DL (2003) The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr 22(3):235–239

    Article  PubMed  Google Scholar 

  9. Bozzetti F, Gianotti L, Braga M, Di Carlo V, Mariani L (2007) Postoperative complications in gastrointestinal cancer patients: the joint role of the nutritional status and the nutritional support. Clin Nutr 26(6):698–709

    Article  PubMed  Google Scholar 

  10. Sungurtekin H, Sungurtekin U, Balci C, Zencir M, Erdem E (2004) The influence of nutritional status on complications after major intraabdominal surgery. J Am Coll Nutr 23(3):227–232

    Article  PubMed  Google Scholar 

  11. Hamishehkar H, Ranjdoost F, Asgharian P, Mahmoodpoor A, Sanaie S (2016) Vitamins, are they safe? Adv Pharm Bull 6(4):467–477

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Yu J, Hunter PJ, Perry JA, Cross KM (2016) Plastic surgery patients are malnourished: utilizing the Canadian malnutrition screening tool. Plast Reconstr Surg Glob Open 4(9):e1058

    Article  PubMed  PubMed Central  Google Scholar 

  13. Bird JK, Murphy RA, Ciappio ED, McBurney MI (2017) Risk of deficiency in multiple concurrent micronutrients in children and adults in the United States. Nutrients 9(7). https://doi.org/10.3390/nu9070655

  14. Polania Gutierrez J, Rocuts K (2023) Perioperative anticoagulation management. StatPearls

    Google Scholar 

  15. Hornor MA, Duane TM, Ehlers AP et al (2018) American College of Surgeons' guidelines for the perioperative management of antithrombotic medication. J Am Coll Surg 227(5):521–536.e1

    Article  PubMed  Google Scholar 

  16. Zinder R, Cooley R, Vlad LG, Molnar JA (2019) Vitamin A and wound healing. Nutr Clin Pract 34(6):839–849

    Article  PubMed  Google Scholar 

  17. Vitagliano T, Garieri P, Lascala L et al (2023) Preparing Patients for cosmetic surgery and aesthetic procedures: ensuring an optimal nutritional status for successful results. Nutrients 15(2). https://doi.org/10.3390/nu15020352

  18. Tan SR, Tope WD (2004) Effect of acitretin on wound healing in organ transplant recipients. Dermatol Surg 30(4 Pt 2):667–673

    PubMed  Google Scholar 

  19. van Anholt RD, Sobotka L, Meijer EP et al (2010) Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients. Nutrition. 26(9):867–872

    Article  PubMed  Google Scholar 

  20. Tom WL, Peng DH, Allaei A, Hsu D, Hata TR (2005) The effect of short-contact topical tretinoin therapy for foot ulcers in patients with diabetes. Arch Dermatol 141(11):1373–1377

    Article  PubMed  CAS  Google Scholar 

  21. Theilla M, Singer P, Cohen J, Dekeyser F (2007) A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: a randomized, prospective, controlled study. Clin Nutr 26(6):752–757

    Article  PubMed  CAS  Google Scholar 

  22. Fang KM, Wang CT, Chen YW, Huang TW (2015) Reduction of adhesions and antrostomy stenosis with topical vitamin A after endoscopic sinus surgery. Am J Rhinol Allergy 29(6):430–434

    Article  PubMed  Google Scholar 

  23. Pfeiffer CM, Sternberg MR, Schleicher RL, Haynes BM, Rybak ME, Pirkle JL (2013) The CDC's second national report on biochemical indicators of diet and nutrition in the U.S. Population is a valuable tool for researchers and policy makers. J Nutr Jun 143(6):938S–947S

    Article  CAS  Google Scholar 

  24. Mechanick JI, Apovian C, Brethauer S et al (2020) Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic and Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists. Obesity (Silver Spring) 28(4):O1–O58

    Article  PubMed  Google Scholar 

  25. Via MA, Mechanick JI (2017) Nutritional and micronutrient care of bariatric surgery patients: current evidence update. Curr Obes Rep 6(3):286–296

    Article  PubMed  Google Scholar 

  26. Ballew C, Bowman BA, Sowell AL, Gillespie C (2001) Serum retinol distributions in residents of the United States: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 73(3):586–593

    Article  PubMed  CAS  Google Scholar 

  27. Wilson RB (2020) Pathophysiology, prevention, and treatment of beriberi after gastric surgery. Nutr Rev 78(12):1015–1029

    Article  PubMed  PubMed Central  Google Scholar 

  28. Gardiner S, Hartzell T (2015) Thiamine deficiency: a cause of profound hypotension and hypothermia after plastic surgery. Aesthet Surg J 35(1):NP1-3

    Article  PubMed  Google Scholar 

  29. Sebastian JL, V JM, Tang LW, Rubin JP. (2010) Thiamine deficiency in a gastric bypass patient leading to acute neurologic compromise after plastic surgery. Surg Obes Relat Dis 6(1):105–106

    Article  PubMed  Google Scholar 

  30. Janis JE, Jefferson RC, Kraft CT (2020) Panniculectomy: practical pearls and pitfalls. Plast Reconstr Surg Glob Open 8(8):e3029

    Article  PubMed  PubMed Central  Google Scholar 

  31. Mahabadi N, Bhusal A, Banks S (2022) Riboflavin deficiency. StatPearls

    Google Scholar 

  32. Collins TM, Caimi R, Lynch PR et al (1991) The effects of nicotinamide and hyperbaric oxygen on skin flap survival. Scand J Plast Reconstr Surg Hand Surg 25(1):5–7

    Article  PubMed  CAS  Google Scholar 

  33. Im MJ, Hoopes JE (1989) Improved skin flap survival with nicotinic acid and nicotinamide in rats. J Surg Res 47(5):453–455

    Article  PubMed  CAS  Google Scholar 

  34. Villaverde Doménech ME, Simón Sanz E, Pujol Marco C, Pérez del Caz MD, Blanco Cerdá O, Pellagra SAJ (Feb 2014) A challenging differential diagnosis in burn injuries. J Tissue Viability 23(1):37–41

    Article  PubMed  Google Scholar 

  35. Djadjo S, Bajaj T (2023) Niacin. StatPearls

    Google Scholar 

  36. O'Connell C, Horwood K, Nadamuni M (2016) Correction of refractory thrombocytopenia and anemia following withdrawal of extended release niacin. Am J Hematol 91(7):E318

    Article  PubMed  Google Scholar 

  37. Aprahamian M, Dentinger A, Stock-Damgé C, Kouassi JC, Grenier JF (1985) Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr 41(3):578–589

    Article  PubMed  CAS  Google Scholar 

  38. Vaxman F, Olender S, Lambert A, Nisand G, Grenier JF (1996) Can the wound healing process be improved by vitamin supplementation? Experimental study on humans. Eur Surg Res 28(4):306–314

    Article  PubMed  CAS  Google Scholar 

  39. Abosamak N, Gupta V Vitamin B6 (Pyridoxine). StatPearls

  40. Lakshmi A, Diwan P, Bamji M (1988) Wound healing in pyridoxine deficiency. Nutr Res 8(10):1203–1206

    Article  CAS  Google Scholar 

  41. Chen LR, Yang BS, Chang CN, Yu CM, Chen KH (2018) Additional vitamin and mineral support for patients with severe burns: a nationwide experience from a catastrophic color-dust explosion event in Taiwan. Nutrients 10(11). https://doi.org/10.3390/nu10111782

  42. Bossard V, Bourmeyster N, Pasini S, et al. Problematic rise of vitamin B6 supplementation overuse and potential risk to bariatric surgery patients. Nutrition Oct 2022;102:111738. https://doi.org/10.1016/j.nut.2022.111738

  43. Bendich A, Cohen M (1990) Vitamin B6 safety issues. Ann N Y Acad Sci 585:321–330

    Article  ADS  PubMed  CAS  Google Scholar 

  44. Bistas K, Tadi P (2023) Biotin, p StatPearls

    Google Scholar 

  45. Soleymani T, Lo Sicco K, Shapiro J (2017) The infatuation with biotin supplementation: is there truth behind its rising popularity? A comparative analysis of clinical efficacy versus social popularity. J Drugs Dermatol 16(5):496–500

    PubMed  CAS  Google Scholar 

  46. Bagheri M, Jahromi BM, Zamani A (2011) Folic acid may be a potential addition to diabetic foot ulcer treatment - a hypothesis. Int Wound J 8(6):658–660

    Article  PubMed  PubMed Central  Google Scholar 

  47. Boykin JV, Hoke GD, Driscoll CR, Dharmaraj BS (2020) High-dose folic acid and its effect on early stage diabetic foot ulcer wound healing. Wound Repair Regen 28(4):517–525

    Article  PubMed  Google Scholar 

  48. de Franciscis S, De Sarro G, Longo P et al (2015) Hyperhomocysteinaemia and chronic venous ulcers. Int Wound J 12(1):22–26

    Article  PubMed  Google Scholar 

  49. Stein JH, McBride PE (1998) Hyperhomocysteinemia and atherosclerotic vascular disease: pathophysiology, screening, and treatment. off. Arch Intern Med 158(12):1301–1306

    Article  PubMed  CAS  Google Scholar 

  50. Myles PS, Chan MT, Forbes A, Leslie K, Paech M, Peyton P (2006) Preoperative folate and homocysteine status in patients undergoing major surgery. Clin Nutr 25(5):736–745

    Article  PubMed  CAS  Google Scholar 

  51. Shankar P, Boylan M, Sriram K (2010) Micronutrient deficiencies after bariatric surgery. Nutrition. 26(11-12):1031–1037

    Article  PubMed  CAS  Google Scholar 

  52. Todorovic V (2002) Food and wounds: nutritional factors in wound formation and healing. Br J Community Nurs 43-4:46–48

    Google Scholar 

  53. Findlay CW (Mar 1953) Effect of vitamin B12 on wound healing. Proc Soc Exp Biol Med 82(3):492–495

    Article  PubMed  CAS  Google Scholar 

  54. Fähndrich C, Gemperli A, Baumberger M et al (2024) Risk factors of major complications after flap surgery in the treatment of stage III and IV pressure injury in people with spinal cord injury/disorder: a retrospective cohort study. Spinal Cord 62(1):34–41

    Article  PubMed  Google Scholar 

  55. Kiasari AZ, Firouzian A, Baradari AG, Nia HS, Kiasari SH (2014) The effect of vitamin B12 infusion on prevention of nitrous oxide-induced homocysteine increase: a double-blind randomized controlled trial. Oman Med J 29(3):194–197

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  56. Ankar A, Kumar A Vitamin B12 Deficiency. StatPearls

  57. Schijns W, Homan J, van der Meer L et al (2018) Efficacy of oral compared with intramuscular vitamin B-12 supplementation after Roux-en-Y gastric bypass: a randomized controlled trial. Am J Clin Nutr 108(1):6–12

    Article  PubMed  Google Scholar 

  58. Lund CC, Crandon JH (1941) Ascorbic acid and human wound healing. Ann Surg 114(4):776–790

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  59. ter Riet G, Kessels AG, Knipschild PG (1995) Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. J Clin Epidemiol 48(12):1453–1460

    Article  PubMed  Google Scholar 

  60. Odgaard KM, Anderen NB, Munk C, Wessel I, Andersen JR (2019) SUN-PO310: a randomized controlled clinical trial of pre- and postoperative supplementation with zinc, Vitamin C, Arginine and multivitamin in patients operated for head and neck cancer. Clin Nutr 38(1). https://doi.org/10.1016/S0261-5614(19)32940-1

  61. Amirlak B, Mahedia M, Shah N (2016) A clinical evaluation of efficacy and safety of hyaluronan sponge with Vitamin C versus placebo for scar reduction. Plast Reconstr Surg Glob Open 4(7):e792

    Article  PubMed  PubMed Central  Google Scholar 

  62. Barbosa E, Faintuch J, Machado Moreira EA et al (2009) Supplementation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: a randomized, double-blind, placebo-controlled pilot study. J Burn Care Res 30(5):859–866

    Article  PubMed  Google Scholar 

  63. Frías Soriano L, Lage Vázquez MA, Maristany CP, Xandri Graupera JM, Wouters-Wesseling W, Wagenaar L (2004) The effectiveness of oral nutritional supplementation in the healing of pressure ulcers. J Wound Care 13(8):319–322

    Article  PubMed  Google Scholar 

  64. Cereda E, Gini A, Pedrolli C, Vanotti A (2009) Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. J Am Geriatr Soc 57(8):1395–1402

    Article  PubMed  Google Scholar 

  65. Zhang H, Qin B, Zhao Y, Zhang R, Zhang G (2023) Effects of vitamin C combined with rbFGF on inflammatory factors and oxygen environment in patients with high-voltage electrical burns. Int Wound J 20(7):2649–2656

    Article  PubMed  PubMed Central  Google Scholar 

  66. Yun IS, Yoo HS, Kim YO, Rah DK (2013) Improved scar appearance with combined use of silicone gel and vitamin C for Asian patients: a comparative case series. Aesthet Plast Surg 37(6):1176–1181

    Article  Google Scholar 

  67. Fukushima R, Yamazaki E (2010) Vitamin C requirement in surgical patients. Curr Opin Clin Nutr Metab Care 13(6):669–676

    Article  PubMed  CAS  Google Scholar 

  68. Razzaghi R, Pourbagheri H, Momen-Heravi M et al (2017) The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. J Diabetes Complicat 31(4):766–772

    Article  Google Scholar 

  69. Smith K, Hewlings S (2021) Correlation between vitamin D levels and hard-to-heal wounds: a systematic review. J Wound Care 30(Sup6):S4–S10

    Article  PubMed  Google Scholar 

  70. Schauber J, Dorschner RA, Coda AB et al (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117(3):803–811

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  71. Burkiewicz CJ, Guadagnin FA, Skare TL, do Nascimento MM, Servin SC, de Souza GD (2012) Vitamin D and skin repair: a prospective, double-blind and placebo controlled study in the healing of leg ulcers. Rev Col Bras Cir 39(5):401–407

    Article  PubMed  Google Scholar 

  72. Halschou-Jensen PM, Sauer J, Bouchelouche P, Fabrin J, Brorson S, Ohrt-Nissen S (2023) Improved healing of diabetic foot ulcers after high-dose Vitamin D: a randomized double-blinded clinical trial. Int J Low Extrem Wounds 22(3):466–474

    Article  PubMed  CAS  Google Scholar 

  73. van der Veer WM, Jacobs XE, Waardenburg IE, Ulrich MM, Niessen FB (2009) Topical calcipotriol for preventive treatment of hypertrophic scars: a randomized, double-blind, placebo-controlled trial. Arch Dermatol 145(11):1269–1275

    PubMed  Google Scholar 

  74. Ince B, Uyar I, Dadaci M (2019) Effect of Vitamin D deficiency on hypertrophic scarring. Dermatol Surg 45(2):274–279

    Article  PubMed  CAS  Google Scholar 

  75. Nair R, Maseeh A (2012) Vitamin D: the "sunshine" vitamin. J Pharmacol Pharmacother 3(2):118–126

    PubMed  PubMed Central  CAS  Google Scholar 

  76. Palacios C, Gonzalez L (Oct 2014) Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol 144, 138(Pt A):–45. https://doi.org/10.1016/j.jsbmb.2013.11.003

  77. LeBlanc E, Chou R, Zakher B, Daeges M, Pappas M. Screening for Vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force recommendation. 2014.

  78. Kahwati LC, LeBlanc E, Weber RP et al (2021) Screening for Vitamin D deficiency in adults: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 325(14):1443–1463

    Article  PubMed  Google Scholar 

  79. Sizar O, Khare S, Goyal A, Givler A (2023) Vitamin D deficiency. StatPearls

    Google Scholar 

  80. Iglar PJ, Hogan KJ (2015) Vitamin D status and surgical outcomes: a systematic review. Patient Saf Surg 9:14

    Article  PubMed  PubMed Central  Google Scholar 

  81. Abdehgah AG, Monshizadeh A, Tehrani MM et al (2020) Relationship between preoperative 25-hydroxy vitamin D and surgical site infection. J Surg Res 245:338–343

    Article  PubMed  CAS  Google Scholar 

  82. Havlik RJ (1997) Vitamin E and wound healing. Plastic Surgery Educational Foundation DATA Committee. Plast Reconstr Surg 100(7):1901–1902

    Article  PubMed  CAS  Google Scholar 

  83. Lee M (1953) An investigation into the value of d, 1-alpha-tocopheryl acetate (vitamin E) in the treatment of gravitational ulcers. Br J Dermatol 65(4):131–138

    Article  PubMed  CAS  Google Scholar 

  84. Stanizzi A, Bottoni M, Tartaglione C, Bolletta E, Benedetto GD (2017) Associated use of silicone-vitamin E gauzes and α-tocopherol acetate oil in healing of skin graft donor sites. Int Wound J 14(5):813–817

    Article  PubMed  PubMed Central  Google Scholar 

  85. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY (2011) A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg 64(6):e137-e145. https://doi.org/10.1016/j.bjps.2010.08.029

  86. Baumann LS, Spencer J (1999) The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 25(4):311–315

    Article  PubMed  CAS  Google Scholar 

  87. Jenkins M, Alexander JW, MacMillan BG, Waymack JP, Kopcha R (1986) Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery. J Burn Care Rehabil 7(4):309–312

    Article  PubMed  CAS  Google Scholar 

  88. Cook M, Johnson N, Zegzula HD, Schray M, Glissmeyer M, Sorenson L (2016) Prophylactic use of pentoxifylline (Trental) and vitamin E to prevent capsular contracture after implant reconstruction in patients requiring adjuvant radiation. Am J Surg 211(5):854–859

    Article  PubMed  Google Scholar 

  89. Zampieri N, Zuin V, Burro R, Ottolenghi A, Camoglio FS (2010) A prospective study in children: pre- and post-surgery use of vitamin E in surgical incisions. J Plast Reconstr Aesthet Surg 63(9):1474–1478

    Article  PubMed  Google Scholar 

  90. Afzali H, Jafari Kashi AH, Momen-Heravi M et al (2019) The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial. Wound Repair Regen 27(3):277–284

    Article  PubMed  Google Scholar 

  91. Fiori G, Galluccio F, Braschi F et al (2009) Vitamin E gel reduces time of healing of digital ulcers in systemic sclerosis. Clin Exp Rheumatol 27(3 Suppl 54):51–54

    PubMed  CAS  Google Scholar 

  92. Palmieri B, Gozzi G, Palmieri G (1995) Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids. Int J Dermatol 34(7):506–509

    Article  PubMed  CAS  Google Scholar 

  93. Perez OA, Viera MH, Patel JK et al (2010) A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars. J Drugs Dermatol 9(5):514–518

    PubMed  Google Scholar 

  94. Sherf-Dagan S, Buch A, Ben-Porat T, Sakran N, Sinai T (2021) Vitamin E status among bariatric surgery patients: a systematic review. Surg Obes Relat Dis 17(4):816–830

    Article  PubMed  Google Scholar 

  95. Traber MG, Manor D (2012) Vitamin E. Adv Nutr 3(3):330–331

    Article  PubMed  PubMed Central  Google Scholar 

  96. Demling RH (2009) Nutrition, anabolism, and the wound healing process: an overview. Eplasty 9:e9

    PubMed  PubMed Central  Google Scholar 

  97. Pazyar N, Houshmand G, Yaghoobi R, Hemmati AA, Zeineli Z, Ghorbanzadeh B (2019) Wound healing effects of topical Vitamin K: A randomized controlled trial. Indian J Pharm 51(2):88–92

    Article  CAS  Google Scholar 

  98. Fusaro M, Gallieni M, Rizzo MA et al (2017) Vitamin K plasma levels determination in human health. Clin Chem Lab Med 55(6):789–799

    Article  PubMed  CAS  Google Scholar 

  99. Toninello P, Montanari A, Bassetto F, Vindigni V, Paoli A (2021) Nutritional support for bariatric surgery patients: the skin beyond the fat. Nutrients 13(5). https://doi.org/10.3390/nu13051565

  100. Sherf-Dagan S, Goldenshluger A, Azran C, Sakran N, Sinai T, Ben-Porat T (2019) Vitamin K-what is known regarding bariatric surgery patients: a systematic review. Surg Obes Relat Dis 15(8):1402-1413. https://doi.org/10.1016/j.soard.2019.05.031

  101. Agha-Mohammadi S, Hurwitz DJ (2008) Nutritional deficiency of post-bariatric surgery body contouring patients: what every plastic surgeon should know. Plast Reconstr Surg 122(2):604–613

    Article  PubMed  CAS  Google Scholar 

  102. Naghshineh N, O'Brien Coon D, McTigue K, Courcoulas AP, Fernstrom M, Rubin JP (2010) Nutritional assessment of bariatric surgery patients presenting for plastic surgery: a prospective analysis. Plast Reconstr Surg 126(2):602–610

    Article  PubMed  CAS  Google Scholar 

  103. Patel JJ, Mundi MS, Hurt RT, Wolfe B, Martindale RG (2017) Micronutrient deficiencies after bariatric surgery: an emphasis on vitamins and trace minerals [Formula: see text]. Nutr Clin Pract 32(4):471–480

    Article  PubMed  CAS  Google Scholar 

  104. Agha-Mohammadi S, Hurwitz DJ (2008) Potential impacts of nutritional deficiency of postbariatric patients on body contouring surgery. Plast Reconstr Surg 122(6):1901–1914

    Article  PubMed  CAS  Google Scholar 

  105. Dolan K, Hatzifotis M, Newbury L, Lowe N, Fielding G (2004) A clinical and nutritional comparison of biliopancreatic diversion with and without duodenal switch. Ann Surg 240(1):51–56

    Article  PubMed  PubMed Central  Google Scholar 

  106. Clements RH, Katasani VG, Palepu R et al (2006) Incidence of vitamin deficiency after laparoscopic Roux-en-Y gastric bypass in a university hospital setting. Am Surg 72:1196–1202; discussion 1203-4

    Article  PubMed  Google Scholar 

  107. Madan AK, Orth WS, Tichansky DS, Ternovits CA (2006) Vitamin and trace mineral levels after laparoscopic gastric bypass. Obes Surg 16(5):603–606

    Article  PubMed  Google Scholar 

Download references

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Division of Plastic and Reconstructive Surgery, Warren Alpert Medical School, Brown University, Providence, RI, 02905, USA

    Navya Baranwal, Jung Ho Gong, Taylor E. Arnoff & Raman Mehrzad

Authors
  1. Navya Baranwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jung Ho Gong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Taylor E. Arnoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Raman Mehrzad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Raman Mehrzad.

Ethics declarations

Competing Interests 

Navya Baranwal, Jung Ho Gong, Taylor E. Arnoff, and Raman Mehrzad declare no conflict of interest.                                             

Ethical Approval

For this review article no ethical approval is required. This article does not contain any studies involving human participants or animals performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baranwal, N., Gong, J.H., Arnoff, T.E. et al. The role and management of vitamin supplementation in plastic surgery patients: A comprehensive review. Eur J Plast Surg 47, 22 (2024). https://doi.org/10.1007/s00238-024-02165-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00238-024-02165-6

Keywords

Search

Navigation