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New chromogenic and fluorogenic reagents and sensors for neutral and ionic analytes based on covalent bond formation–a review of recent developments

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Abstract

To date, hydrogen bonding and Coulomb, van der Waals and hydrophobic interactions are the major contributors to non-covalent analyte recognition using ionophores, ligands, aptamers and chemosensors. However, this article describes recent developments in the use of (reversible) covalent bond formation to detect analyte molecules, with special focus on optical signal transduction. Several new indicator dyes for analytes such as amines and diamines, amino acids, cyanide, formaldehyde, hydrogen peroxide, organophosphates, nitrogen oxide and nitrite, peptides and proteins, as well as saccharides have become available. New means of converting analyte recognition into optical signals have also been introduced, such as colour changes of chiral nematic layers. This article gives an overview of recent developments and discusses response mechanisms, selectivity and sensitivity.

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Acknowledgement

This work was supported by the Heisenberg Fellowship MO 1062/1-1 and research grant MO 1062/2-1 of Deutsche Forschungsgemeinschaft. This support is gratefully acknowledged.

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  1. Institute of Physical Chemistry, Friedrich Schiller University of Jena, Lessingstrasse 10, 07743, Jena, Germany

    Gerhard J. Mohr

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  1. Gerhard J. Mohr
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Correspondence to Gerhard J. Mohr.

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Mohr, G.J. New chromogenic and fluorogenic reagents and sensors for neutral and ionic analytes based on covalent bond formation–a review of recent developments. Anal Bioanal Chem 386, 1201–1214 (2006). https://doi.org/10.1007/s00216-006-0647-3

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