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Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

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Abstract

Most animals have large amounts of the special substance melatonin, which is controlled by the light/dark cycle in the suprachiasmatic nucleus. According to what is now understood, the gastrointestinal tract (GIT) and other areas of the body are sites of melatonin production. According to recent studies, the GIT and adjacent organs depend critically on a massive amount of melatonin. Not unexpectedly, melatonin’s many biological properties, such as its antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-metastasis, and antiangiogenic properties, have drawn the attention of researchers more and more. Because melatonin is an antioxidant, it produces a lot of secretions in the GIT’s mucus and saliva, which shields cells from damage and promotes the development of certain GIT-related disorders. Melatonin’s ability to alter cellular behavior in the GIT and other associated organs, such as the liver and pancreas, is another way that it functions. This behavior alters the secretory and metabolic activities of these cells. In this review, we attempted to shed fresh light on the many roles that melatonin plays in the various regions of the gastrointestinal tract by focusing on its activities for the first time.

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Data availability

No datasets were generated or analysed during the current study.

Abbreviations

GIT:

Gastrointestinal tract

ROS:

Reactive oxygen species

RNS:

Reactive nitrogen species

TNF-α:

Tissue necrosis factor-α

OLP:

Oral lichen planus

LSD1:

Lysine-specific demethylase

PDTX:

Patient-derived tumor xenograft

CREBBP:

CREB-binding protein

TIMP1:

Metalloproteinase1

CXCL:

CXC chemokine ligand

HPDLC:

Human periodontal ligament cells

RANKL:

Receptor activators of the NF-kB ligand

HGF:

Human gingival fibroblast

CNS:

Central nervous system

SOD:

Superoxide dismutase

H. pylori :

Helicobacter pylori

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Authors and Affiliations

  1. Universal Scientific Educational and Research Network (USERN), Tehran, Iran

    Atousa Moghadam Fard

  2. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Pardis Goodarzi

  3. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mehran Mottahedi & Setareh Garousi

  4. Physiotherapy and Rehabilitation Faculty, Medipol University Health of Science, Istanbul, Turkey

    Hamed Zadabhari

  5. Faculty of Paramedicine, Lorestan University of Medical Sciences, Khorram Abad, Iran

    Mohammad Kalantari Shahijan

  6. Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

    Saeedeh Esmaeili

  7. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

    Mohsen Nabi-Afjadi

  8. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Bahman Yousefi

  9. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Bahman Yousefi

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  1. Atousa Moghadam Fard
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The core of study came from MN-A and BY. All authors wrote the manuscript. Final editing was done by MN-A. BY and MN-A supervised the manuscript. The authors confirm that no paper mill and artificial intelligence was used.

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Moghadam Fard, A., Goodarzi, P., Mottahedi, M. et al. Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite. Naunyn-Schmiedeberg's Arch Pharmacol (2024). https://doi.org/10.1007/s00210-024-02972-5

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