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Role of non-coding RNA in immune microenvironment and anticancer therapy of gastric cancer

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Abstract

Gastric cancer remains one of the cancers with the highest mortality in the world; therefore, it is very important to investigate its pathogenesis to improve the prognosis of gastric cancer patients. Recently, noncoding RNAs have become a research hotspot in the field of oncology. These RNA molecules play complex roles in the regulation of tumor cells, immune cells, and the tumor microenvironment. Therefore, studying their ability to regulate the gastric cancer immune microenvironment will provide us with a better perspective to understand their potential role in anticancer therapy. In this review, we discuss the regulatory effects of several common noncoding RNAs on the immune microenvironment of gastric cancer and their prospects in anticancer therapy to provide some novel insight into the identification of valuable diagnostic markers and improving the prognosis of gastric cancer patients.

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Acknowledgements

Thanks for the assistance and support of Y. X. Yang, J. R. Chen, Y. Y. Ding, and S. X. Lin. Thanks for the figure created with BioRender.com. Thanks for the editor and all reviewers for their comments.

Funding

This study was supported in part by Grants from the Programs of National Natural Science Foundation of China (no. 81572372, no. 81974373), National Precision Medicine Research Program (2017YFC0908304), National Key Research and Development Program (MOST-2016YFC1303200), and Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-009A).

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  1. Department of Gastric Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, People’s Republic of China

    Liqiao Chen & Jingyu Deng

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  1. Liqiao Chen
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Jingyu Deng provided direction. Liqiao Chen drafted and revised the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Jingyu Deng.

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The protocol of this research and the license for usage of clinical data were given by the Institutional Research Ethics Committee of Tianjin Medical University Cancer Institute and Hospital (Tianjin, China) (No. bc2019087).

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Chen, L., Deng, J. Role of non-coding RNA in immune microenvironment and anticancer therapy of gastric cancer. J Mol Med 100, 1703–1719 (2022). https://doi.org/10.1007/s00109-022-02264-6

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