Summary
When acting upon the isolated heart or administered into the blood flow, concentrations of 2-methylnaphthoquinone (1: 50,000–1: 100,000) provoke a decrease and disappearance, first of the inotropic component of the parasympathetic effect, then the vagal arrest, and, lastly, the inhibition of chronotropic component. These changes are caused by the disturbance of the acetylcholine metabolism and the liberation of this substance in the nerve endings of the vagus. Besides, large concentrations (1: 10,000) render a nonspecific altering effect on the cardiac elements.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
L. N. Zefirov and A. V. Kibyakov. Fiziol. Zhur. SSSR. No. 2, 183 (1954).
L. N. Zefirov and O. S. Kochnev Byull. Éksptl. Biol. i Med.45, 4, 3 (1958). Original Russian pagination. See C.B. Translation.
L. N. Zefirov and G. I. Poltaev. Byull. Éksptl. Biol. i Med.47, 6, 68 (1959). Original Russian pagination. See C.B. Translation.
M. A. Keder-Stepanov. Byull. Éksptl. Biol. i. Med43, 5, 12 (1957). Original Russian pagination. See C.B. Translation.
A. V. Kibyakov and Z. I. Pen'kina, Byull. Éksptl. Biol. i Med.34, 7 20 (1952).
A. V. Kibyakov, Z. I. Pen'kina and R. G. Porkhovnikov. Byull. Éksptl. Biol. i Med.34, 8, 24 (1952).
O. D. Kurmaev, Byull. Éksptl. Biol. i Med.8, 9–10, 262 (1939).
O. D. Kurmaev, in: Transactions of the All-Union Society of Physiologists, Biochemists and Pharmaologists [in Russian] (Moscow, 1952) v. 1, p. 85.
G. D. Smirnov and Ts. V. Serbenyuk, Doklady Akad. Nauk SSSR62, 5, 725 (1948).
T. M. Turpaev and V. A. Shaternikov, Byull. Éksptl. Biol. i Med38, 8, 3 (1954).
M. G. Udel'nov and I. A. Kelareva, Byull. Éksptl. Biol. i Med.11, 4, 354 (1941).
M. G. Udel'nov, in: Collected Reports of the 7th All-Union Conference of Physiologists, Biochemists and Pharmacologist [in Russian] (Moscow, 1947) p. 313.
M. G. Udel'nov, Uspekhi Sovremennoi Biol.44, 3, 334 (1957).
S. Briscoe, J. Physiol.126, 3, 623 (1954).
E. Bulbring and J.H. Burn. J. Physiol.108, 4, 508 (1949)
W. H. Summerson, Federation proceedings2, 1, 72 (1943).
C. Torda and H. G. Wolff, Proc. Soc. Exp. Biol. Med.57, 236 (1944).
C. Torda and H. G. Wolff, Science,103, 645–646 (1946).
C. Torda and H. G. Wolff, Am. J. Physiol.158 3, 465 (1949).
M. S. Weiss, A. Voripaieff, D. Nachmanson, Federation proceedings,17, 198 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zefirov, L.N., Tukhvatullina, L.V. The effect of 2-methylnaphthoquinone on the parasympathetic innervation and cardiac activity of cold-blooded animals. Bull Exp Biol Med 49, 376–379 (1960). https://doi.org/10.1007/BF00781950
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00781950