Abstract
This chapter entitled “ROS/Redox Regulation with Dietary Phytochemicals and Role in Anticancer Activity” initially introduces the classification of various plant products (phytochemicals) with experimental anticancer activities. Redox regulation and anticancer activities of various natural dietary compounds have been discussed extensively at experimental, preclinical, and clinical situations. Further, a few select important phytochemicals with dietary anticancer properties were presented to demonstrate their molecular and redox signaling activities in various studies. In the end, the role of specific natural chemopreventive antioxidants has been discussed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abarikwu SO, Pant AB, Farombi EO (2012) Dietary antioxidant, quercetin, protects sertoli germ cell coculture from atrazine induced oxidative damage. J Biochem Mol Toxicol 26:477–485
Abiko Y, Toriba A, Kumagai Y (2023) Phytochemicals to regulate oxidative and electrophilic stress through Nrf2 activation. Redox Exp Med 2023:e220021
Adhami VM, Siddiqui IA, Ahmad N, Gupta S, Mukhtar H (2004) Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res 64:8715–8722
Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363–398
Aguilo JIJ, Iturralde M, Monleon I, Inarrea P, Pardo J et al (2012) Cytotoxicity of quinine drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications. Chem Biol Interact 198:18–28
Aherne SA, O'Brien NM (1999) Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells. Nutr Cancer 34:160–166
Ahmad N, Gupta S, Mukhtar H (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Arch Biochem Biophys 376:338–346
Ahmad IU, Forman JD, Sarkar FH, Hillman GG, Heath E et al (2010) Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer. Nutr Cancer 62:996–1000
Ak T, Gulcin I (2008) Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 174:27–37
Akyol H, Riciputi Y, Capanoglu E, Caboni MF, Verardo V (2016) Phenolic compounds in the potato and its byproducts: an overview. Int J Mol Sci 17:835. 19 pages
Amin AR, Kucuk O, Khuri FR, Shin DM (2009) Perspectives for cancer prevention with natural compounds. J Clin Oncol 27:2712–2725
Anantharaju PG, Gowada PC, Vimalambike MG, Madhunapantula SV (2016) An overview on the role of dietary phenolics for the treatment of cancers. Nutr J 15:99–114
Anantharaju PG, Reddy DB, Padukudru MA, Chitturi CMK, Vimalambike MG, Madhunapantula SV (2017) Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). PLoS One 12:e0186208
Andreadi CK, Howells LM, Atherfold PA, Manson MM (2006) Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol Pharmacol 69:1033–1040
Arts IC, Hollman PC (2005) Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 81:317S–325S
Asemani Y, Zamani N, Bayat M, Amirghofran Z (2019) Allium vegetables for possible future of cancer treatment. Phytother Res 33:3019–3039
Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (2009) Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch Biochem Biophys 486:95–102
Aziz MH, Nihal M, Fu VX, Jarrard DF, Ahmad N (2006) Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family protients. Mol Cancer Ther 5:1335–1341
Badr DA, Amer ME, Abd-Elhay WM, Nasr MS, Abuamara TM, Ali H et al (2019) Histopathological and genetic changes proved the anticancer potential of free and nano-capsulated sinapic acid. Appl Biol Chem 62:59
Balaji C, Muthukumaran J, Nalini N (2014) Chemopreventive effect of sinapic acid on 1,2-demethylhydrazine-induced experimental rat colon carcinogenesis. Hum Exp Toxicol 33:1253–1268
Balogun E, Hoque M, Gong P, Killeen E, Green CJ et al (2003) Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371:887–895
Banerjee S, Li Y, Wang Z, Sarkar FH (2008) Multi-targeted therapy of cancer by genistein. Cancer Lett 269:226–242
Barzegar A, Moosavi-Movahedi AA (2011) Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin. PLoS One 6:e26012
Bassiouny AR, Atteya MA, Fatma H, Neenaa HM (2011) Curcumin and EGCG suppress apurinic/apyrimidinic endonuclease 1 and induce complete remission in B-cell non-Hodgkin’s lymphoma patients. Funct Foods Health Dis 1:525–544
Basten GP, Bao Y, Williamson G (2002) Sulforaphane and its glutathione conjugate but not sulforaphanenitrile induce UDP-glucuronosyltransferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis 23:1399–1404
Batra S, Sahu RP, Kandala PK, Srivastava SK (2010) Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. Mol Cancer Ther 9:1596–1608
Benitez DA, Pozo-Guisado E, Alvarez-Barrientos A, Femandez-Salguero PM, Castellon EA (2007) Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines. J Androl 28:282–293
Bhatia N, Gupta P, Singh B, Koul A (2015) Lycopene enriched tomato extract inhibits hypoxia, angiogenesis, and metastatic markers in early stage N-nitrosodiethylamine induced hepatocellular carcinoma. Nutr Cancer 67:1268–1275
Bhattacharjee S, Rana T, Sengupta A (2007) Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev 8:578–582
Bhaumik S, Anjum R, Rangaraj N, Pardhasaradhi BVV, Khar A (1999) Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett 456:311–314
Bi Y, Shen C, Li C, Liu Y, Gao D et al (2016) Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells. Tumor Biol 37:3549–3560
Birková A, Hubková B, Bolerázska B, Mareková M, Čižmárová B (2020) Caffeic acid: a brief overview of its presence, metabolism, and bioactivity. Bioact Compd Health Dis 3:74–81
Biswas P, Dey D, Biswas PK, Rahaman TI, Saha S, Parvez A et al (2022) A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells. Int J Mol Sci 23:11746
Blasiak J, Trzeciak A, Kowaalik J (1999) Curcumin damages DNA in human gastric mucosa cells and lymphocytes. J Environ Pathol Toxicol Oncol 18:271–276
Bley K, Boorman G, Mohammad B, McKenzie D, Babbar S (2012) A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol 40:847–873
Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C (2008) Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int J Cancer 123:1227–1239
Bode AM, Dong Z (2011) The two faces of capsaicin. Cancer Res 71:2809–2814
Bonofiglio D, Giordano C, DeAmicis F, Lanzino M, Ando S (2016) Natural products as promising antitumoral agents in Breast cancer: Mechanisms of action and molecular targets. Mini Rev Med Chem 16:596–604
Boreddy SR, Srivastava SK (2013) Pancreatic cancer chemoprevention by phytochemicals. Cancer Lett 334:86–94
Boreddy SR, Pramanik KC, Srivastava SK (2011a) Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin Cancer Res 17:1784–1795
Boreddy SR, Sahu RP, Srivastava SK (2011b) Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-alpha/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS One 6:e25799
Bouayed J, Bohn T (2010) Exogenous antioxidants – Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative Med Cell Longev 3:228. 19 pages
Brooks JD, Paton VG, Vidanes G (2001) Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomark Prev 10:949–954
Brusselmans K, DeSchnjver E, Heyns W, Verhoeven G, Swinnen JV (2003) Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int J Cancer 106:856–862
Cao J, Jia L, Zhou HM, Liu Y, Zhong LF (2006) Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol Sci 91:476–483
Cao J, Liu Y, Jia L, Zhou HM, Kong Yet al. (2007) Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic Biol Med 43:968–975
Chakraborty A, Gupta N, Ghosh K, Roy P (2010) In vitro evaluation of the cytotoxic anti-proliferative and anti-oxidant properties of pterostilbene isolated from Pterocarpus marsupium. Toxicol In Vitro 24:1215–1228
Chen C, Kong AN (2004) Dietary chemopreventive compounds and ARE/EpREsignaling. Free Radic Biol Med 36:1505–1516
Chen C, Kong AN (2005) Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 26:318–326
Chen YR, Tan TH (1998) Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 17:173–178
Chen YR, Wang W, Kong ANT, Tan TH (1998) Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J Biol Chem 273:1769–1775
Chen C, Shen G, Hebbar V, Hu R, Owuor ED, Kong AN (2003) Epigal-locatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 24:1369–1378
Chen Y, Tseng SH, Lai HS, Chen WJ (2004) Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery 136:57–66
Chen CY, Jang JH, Li MH, Surh YJ (2005) Resveratrol upregulate sheme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun 331:993–1000
Chen C, Zhou J, Ji C (2010) Quercetin: a potential drug to reverse multidrug resistance. Life Sci 87:333–338
Chen S, Xiong GS, Wu S, Mo J (2012) Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro. Cancer Biother Radiopharm 28:169–176
Chen CY, Chen KC, Yang TY, Liu HC, Hsu SL (2013) Gallic acid induces a reactive oxygen species-provoked c-Jun NH2-terminal kinase-dependent apoptosis in lung fibroblasts. Evid Based Complement Alternat Med 2013:613950. 12 pages
Chen M, Meng H, Zhao Y, Chen F, Yu S (2015) Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses. BMC Complement Altern Med 15:313. 8 pages
Chien SY, Wu YC, Chung JG, Yang JS, Lu HF et al (2009) Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Human Exp Toxicol 28:493–503
Chio IIC, Tuveson DA (2017) ROS in cancer: the burning question. Trends Mol Med 23:411–429
Choi EJ, Bae SM, Ahn WS (2008) Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch Pharm Res 31:1281–1285
Chou YC, Chang MY, Wang MJ, Harnod T, Hung CH et al (2015) PEITC induces apoptosis of human brain glioblastoma GBM8401 cells through the extrinsic- and intrinsic -signaling pathways. Neurochem Int 81:32–40
Choudhuri T, Pal S, Agwarwal M, Das T, Sa G (2002) Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett 512:334–340
Chu Q, Ling MT, Feng H, Cheng HW, Tsao SW, Wang X et al (2006) A novel anticancer effect of garlic derivatives: inhibition of cancer cell invasion through restoration of E-cadherin expression. Carcinogenesis 27:2180–2189
Chuang CY, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL (2010) Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. J Agric Food Chem 58:2943–2951
Chung SS, Vadgama JV (2015) Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3–NFκB signaling. Anticancer Res 35:39–46
Clark R, Lee SH (2016) Anticancer properties of capsaicin against human cancer. Anticancer Res 36:837–843
Dajas F (2012) Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol 143:383–396
Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ et al (2009) Lung tumor promotion by curcumin. Carcinogenesis 30:1016–1023
Das I, Saha T (2009) Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma. Nutrition 25:459–471
Das I, Chakrabarty RN, Das S (2004) Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev 5:70–76
Das I, Das S, Saha T (2010) Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: a histopathological study. Acta Histochem 112:317–327
Deepika, Maurya PK (2022) Health benefits of quercetin in age-related diseases. Molecules 27:2498
Dhillon H, Chikara S, Reindl KM (2014) Piperlongumine induces pancreatic cancer cell death by enhancing reactive oxygen species and DNA damage. Toxicol Rep 1:309–318
Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N et al (2005) Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc Natl Acad Sci U S A 102:4584–4589
Duraj J, Zazrivcova J, Bodo M, Sulikova M, Sedlak J (2005) Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants. Neoplasma 52:273–279
Estrov Z, Shishodia S, Faderi S, Harris D, Van Q et al (2003) Resveratrol blocks interleukin -1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest and induces apoptosis of acute myeloid leukemia cells. Blood 102:987–995
Fan S, Meng Q, Auborn K, Carter T, Rosen EM (2006) BRCA1-and BRCA2 as molecular targets for phytochemicals indole -3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer 94:407–426
Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM (2009) Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res 69:6083–6091
Fang Y, DeMarco VG, Nicholl MB (2012) Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103:1090–1098
Fatma H, Siddique HR (2022) Research and patents status of selected phytochemicals against cancer: how close and how far? Recent pat. Anticancer Drug Discov 2022:18
Fatma H, Jameel M, Siddique HR (2023) An update on phytochemicals in redox homeostasis: Virtuous or Evil in cancer chemoprevention? Chemistry 5:201–222
Ferraresi R, Troiano L, Roat E, Lugli E, Nemes E et al (2005) Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin. Free Radic Res 39:1249–1258
Fimognari CM, Nusse R, Cesari R, Iori G, Cantelli-Forti P et al (2002) Growth inhibition, cell cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis 23:581–586
Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL et al (2007) Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metab Dispos 35:995–1000
Fofaria NM, Kim SH, Srivastava SK (2014) Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation. PLoS One 9:e94298
Fofaria NM, Qhattal HS, Liu X, Srivastava SK (2016) Nanoemulsion formulations for anti-cancer agent piplartine—Characterization, toxicological, pharmacokinetics and efficacy studies. Int J Pharm 498:12–22
Fulda S, Debatin KM (2004) Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res 64:337–346
Furtado RA, De Araujo FRR, Resende FA, Cunha WR, Tavares DC (2010) Protective effect of rosmarinic acid on V79 cells evaluated by the micronucleus and comet assays. J Appl Toxicol 30:254–259
Gaikwad S, Srivastava SK (2021) Role of phytochemicals in perturbation of redox homeostasis in cancer. Antioxidants 10:83
Gamet-Payrastre L, Lumeau S, Gasc N, Cassar G, Rollin P et al (1998) Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. Anti-Cancer Drugs 9:141–148
Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Terce F (2000) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 60:1426–1433
Gersey ZC, Rodriguez GA, Barbarite E, Sanchez A, Walters WM et al (2017) Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species. BMC Cancer 17:99. 11 pages
Gibellini L, Pinti M, Nasi M, Biasi SD, Roat E et al (2010) Interfering with ROS metabolism in cancer cells: the potential role of quercetin. Cancers (Basel) 2:1288–1311
Gibellini L, Bianchini E, De Biasi S, Nasi M, Cossarizza A, Pinti M (2015) Natural compounds modulating mitochondrial functions. Evid Based Complement Alternat Med 2015:527209. 13 pages
Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, Watson RWG (2007) Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms. Prostate 67:1641–1653
Gogada R, Amadori M, Zhang H, Jones A, Verone A et al (2011) Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Cell Cycle 10:4128–4137
Gokbulut AA, Apchan E, Baran Y (2013) Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cyclic arrest. Hematology 18:144–150
Gonzalez-Vallinas M, Gonzalez-Castejon M, Rodriguez-Casado A, de Molina R (2013) Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives. Nutr Rev 71:585–599
Goodman M, Bostick RM, Kucuk O, Jones DP (2011) Clinical trials of antioxidants as cancer prevention agents: past, present, and future. Free Radic Biol Med 51:1068–1084
Gorgani L, Mohammadi M, Najafpour GD, Nikzad M (2017) Piperine – the bioactive compound of black pepper: from isolation to medicinal formulations. Compr Rev Food Sci Food 16:124–140
Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S (2006) Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr 136:2715–2721
Gu JJ, Qiao KS, Sun P, Chen P, Li Q (2018) Study of EGCG induced apoptosis in lung cancer cells by inhibiting PI3K/Akt signaling pathway. Eur Rev Med Pharmacol Sci 22:4557–4563
Gunasekaran V, Elangovan K, Niranjali Devaraj S (2017) Targeting hepatocellular carcinoma with piperine by radical-mediated mitochondrial pathway of apoptosis: an in vitro and in vivo study. Food Chem Toxicol 105:106–118
Gupta P, Srivastava SK (2012) Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Med 10:80
Gupta P, Adkins C, Lockman P, Srivastava SK (2013a) Metastasis of breast tumor cells to brain is suppressed by phenethyl isothiocyanate in a novel in vivo metastasis model. PLoS One 8:e67278
Gupta P, Bansal MP, Koul A (2013b) Spectroscopic characterization of Lycopene extract from Lycopersicum esculentum (Tomato) and its evaluation as a chemopreventive agent against experimental hepatocarcinogenesis in mice. Phytother Res 434:479–485
Gupta P, Bansal MP, Koul A (2013c) Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis. Biochem Biophys Res Commun 434:479–485
Gupta P, Bhatia N, Bansal MP, Koul A (2016) Lycopene modulates cellular proliferation, glycolysis and hepatic ultra-structure during hepatocellular carcinoma. World J Hepatol 8:1222–1233
Gupta N, Verma K, Nalla S, Kulshreshtha A, Lall R, Prasad S (2020) Free radicals as a double-edged sword: the cancer preventive and therapeutic roles of curcumin. Molecules 25:5390
Harikumar KB, Aggarwal BB (2008) Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7:1020–1035
He W, Li X, Xia S (2018) Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells via mitochondrial mediated apoptosis, ROS generation, loss of mitochondrial membrane potential and downregulation of m-TOR/PI3Ksol; AKT signalling pathway. J BUON 23:635–640
Hecht SS (2000) Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev 32:395–411
Herman-Antosiewicz A, Powolny AA, Singh SV (2007) Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacol Sinica 28:1355–1364
Hewlings SJ, Kalman DS (2017) Curcumin: a review of its’ effects on human health. Foods 6:92
Higdon JV, Delage B, Williams DE, Dashwood RH (2007) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 55:224–236
Hillman GG, Singh-Gupta V (2011) Soy isoflavones sensitize cancer cells to radiotherapy. Free Radic Biol Med 51:289–298
Hong YH, Uddin H, Jo U, Kim B, Song J et al (2015) ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis. Front Oncol 5:167. 9 pages
Horvathova K, Novotny L, Vachalkova A (2003) The free radical scavenging activity of four flavonoids determined by the comet assay. Neoplasma 50:291–295
Horvathova K, Chalupa I, Sebova L, Tothova D, Vachalkova A (2005) Protective effect of quercetin and luteolin in human melanoma HMB-2 cells. Mutat Res 565:105–112
Hosseini A, Ghorbani A (2015) Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phyomed 5:84–97
Hsieh TC, Wu JM (1999) Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp Cell Res 249:109–115
Hu R, Kim BR, Chen C, Hebbar V, Kong AN (2003) The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis 24:1361–1367
Hu R, Khor TO, Shen G, Jeong WS, Hebbar V, Chen C et al (2006) Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27:2038–2046
Huang WY, Cai YZ, Zhang Y (2010) Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 62:1–20
Imani A, Maleki N, Bohlouli S, Kouhsoltani M, Sharifi S, Maleki Dizaj S (2021) Molecular mechanisms of anticancer effect of Rutin. Phytother Res 35:2500–2513
Impheng H, Pongcharoen S, Richert L, Pekthong D, Srisawang P (2014) The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS One 9:e107842
Jaganathan SK, Supriyanto E, Mandal M (2013) Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells. World J Gastroenterol 19:7726–7734
Jana NR, Dikshit P, Goswami A, Nukina N (2004) Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem 279:11680–11685
Jang JH, Surh YJ (2001) Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells. Mutation Res 496:181–190
Jang JH, Surh YJ (2003) Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med 34:1100–1110
Jang M, Cai L, Udeani GO, Stowing KV, Thomas CF et al (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218–220
Jeong WS, Kim IW, Hu R, Kong AN (2004) Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm Res 21:661–670
Jeong WS, Jun M, Kong AN (2006) Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid Redox Signal 8:99–106
Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ (2009) Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem 106:73–82
Jiang ZQ, Chen C, Yang B, Hebbar V, Kong ANT et al (2003) Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers. Life Sci 72:2243–2253
Jin L, Li C, Xu Y, Wang L, Liu J, Wang D et al (2013) Epigallocatechingallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cells. Oncol Rep 29:1983–1990
Jordan MJ, Lax V, Rota MC, Loran S, Sotomayor JA (2012) Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of rosmarinusofficinalis (L.) methanolic extracts. J Agric Food Chem 60:9603–9608
Jung YD, Ellis LM (2001) Inhibition of tumour invasion and angiogenesis by epigallocatechingallate (EGCG), a major component of green tea. Int J Exp Pathol 82:309–316
Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK (2005) Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 26:1905–1913
Kachadourian R, Day BJ (2006) Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med 41:65–76
Kaefer CM, Milner JA (2008) The role of herbs and spices in cancer prevention. J Nutr Biochem 19:347–361
Kai L, Samuel SK, Levenson AS (2010) Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NURD complex. Int J Cancer 126:1538–1548
Kalkunte S, Swamy N, Dizon DS, Brard L (2006) Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro. J Exp Ther Oncol 5:287–300
Kang JW, Kim JH, Song K, Kim SH, Yoon JH, Kim KS (2010) Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Phytother Res 24:S77–S82
Karakurt S (2016) Modulatory effects of Rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells. Acta Pharma 66:491–502
Karmakar S, Banik NL, Patel SJ, Ray SK (2006) Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cells. Neurosci Lett 407:53–58
Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe S (2016) Benzyl isothiocyanate (BITC) induces reactive oxygen species-dependent repression of STAT3 protein by down-regulation of specificity proteins in pancreatic cancer. J Biol Chem 291:27122–27133
Kassi E, Chinou I, Spilioti E, Tsiapara A, Graikou K, Karabournioti S, Manoussakis M, Moutsatsou P (2014) A monoterpene, unique component of thyme honeys, induces apoptosis in prostate cancer cells via inhibition of NF-kappaB activity and IL-6 secretion. Phytopathol Mediterr 21:1483–1489
Kassie F, Pool-Zobel B, Parzefall W, Knasmuller S (1999) Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent. Mutagenesis 14:595–603
Katiyar SK, Agarwal R, Mukhtar H (1993) protective effects of green tea polyphenols administered by oral intubation against chemical carcinogen-induced forestomach and pulmonary neoplasia in A/J mice. Cancer Lett 73:167–172
Katiyar SK, Afaq F, Azizuddin K, Mukhtar H (2001) Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (−)-epigallocatechin-3-gallate. Toxicol Appl Pharm 176:110–117
Kaur R, Arora S (2013) Interactions of betulinic acid with xenobiotic metabolizing and antioxidative enzymes in DMBA-treated Sprague Dawley female rats. Free Radic Biol Med 65:131–142
Kaur G, Verma N (2015) Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency. Biotechnol Rep 6:64–78
Kensler TW, Egner PA, Dolan PM, Groopman JD, Roebuck BD (1987) Mechanism of protection against aflatoxintumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1, 2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer Res 47:4271–4277
Keum YS, Jeong WS, Kong AN (2004) Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms. Mutation Res 555:191–202
Khaket TP, Singh MP, Khan I, Kang SC (2020) In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells. Pharm Res 161:105156
Khan M, Maryam A, Zhang H, Mehmood T, Ma T (2016) Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med 20:389–402
Khor TO, Keum YS, Lin W, Kim JH, Hu R, Shen G et al (2006a) Combined inhibitory effects of curcumin and phenethylisothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 66:613–621
Khor TO, Huang MT, Kwon KH, Reddy BS, Kong AN (2006b) Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 66:11580–11584
Kim MY (2012) Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Rep 5:585–591
Kim JE, Kim AR, Chung HY, Han SY, Kim BS, Choi JS (2003a) In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longa. Phytother Res 17:481–484
Kim BR, Hu R, Keum YS, Hebbar V, Shen G, Nair SS et al (2003b) Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Res 63:7520–7525
Kim SY, Jung SH, Kim HS (2005) Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem Biophys Res Commu 337:510–516
Kim JH, Xu C, Keum YS, Reddy B, Conney A, Kong AN (2006) Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethylisothiocyanate and curcumin. Carcinogenesis 27:475–482
Kim YH, Lee DH, Jeong JH, Guo ZS, Lee YJ (2008) Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol 7:1946–1958
Kingsley K, Truong K, Low E, Hill CK, Chokshi SB, Phipps D et al (2011) Soy Protein extract (SPE) exhibits differential in vitro cell proliferation effects in oral cancer and normal cell lines. J Diet Suppl 8:169–188
Kivilompolo M, Oburka V, Hyotylainen T (2007) Comparison of GC-MS and LC-MS methods for the analysis of antioxidant phenolic acids in herbs. Anal Bioanal Chem 388:881–887
Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I (2008) Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 294:L478–L488
Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B (1995) Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J 311:453–459
Komori A, Yatsunami J, Okabe S, Abe S, Hara K et al (1993) Anticarcinogenic activity of green tea polyphenols. Jpn J Clin Oncol 23:186–190
Kong AN, Yu R, Chen C, Mandlekar S, Primiano T (2000) Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch Pharm Res 23:1–16
Kong ANT, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mendlekar S (2001) Signal transduction events elicited by cancer prevention compounds. Mutat Res 481:231–241
Kou X, Kirberger M, Yang Y, Chen N (2013) Natural products for cancer prevention associated with Nrf2-ARE pathway. Food Sci Human Wellness 2:22–28
Koul A, Arora N, Tanwar L (2010) Lycopene mediated modulation of 7,12-dimethlybenz (A) anthracene induced hepatic clastogenicity in male Balb/c mice. Nutricion Hospitalaria 25:304–310
Kumar D, Kumar M, Saravanan C, Singh SK (2012) Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets 16:959–972
Lambert JD, Hong J, Yang GY, Liao J, Yang CS (2005) Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr 81:284S–291S
Lee YJ, Liao PH, Chen WK, Yang CY (2000) Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells. Cancer Lett 153:51–56
Lee ER, Kang YJ, Kim HJ, Choi HY, Kang GH et al (2008) Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells. J Cell Biochem 104:259–273
Lee YJ, Kim NY, Suh YA, Lee C (2011) Involvement of ROS in curcumin-induced autophagic cell death. Korean J Physiol Pharmacol 15:1–7
Lee EB, Cheon MG, Cui J, Lee YJ, Seo EK, Jang HH (2017) The quinine-based derivative, HMNQ induces apoptotic and autophagic cell death by modulating reactive oxygen species in cancer cells. Oncotarget 8:99637–99648
Li W, Nie S, Yu Q, Xie M (2009) (-)-Epigallocatechin-3-gallate induces apoptosis of human hepatoma cells by mitochondrial pathways related to reactive oxygen species. J Agric Food Chem 57:6685–6691
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21:8370–8377
Lima CF, Fernandes-Ferreira M, Pereira-Wilson C (2006) Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci 79:2056–2068
Lin HY, Shih A, Davis FB, Tang HY, Martino LJ et al (2002) Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. J Urol 168:748–755
Lin JF, Tsai TF, Yang SC, Lin YC, Chen HE et al (2017) Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells. Oncotarget 8:20220–20234
Liu BL, Zhang X, Zhang W, Zhen H (2007) New enlightenment of French Paradox: resveratrol’s potential for cancer chemoprevention and anti-cancer therapy. Cancer Biol Ther 6:1833–1836
Liu PL, Tsai JR, Charies AL, Hwang JJ, Chou SH et al (2010) Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase-mediated nuclear factor-kappaB pathway and subsequently downregulating expression of matrix metalloproteinases. Mol Nutr Food Res 54:s196–s204
Liu S, Wang XJ, Liu Y, Cui YF (2013) PI3K/AKT/mTOR signaling is involved in (−)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells. Am J Chin Med 41:629–642
Lu J, Papp LV, Fang J, Rodriguez-Nieto S, Zhivotovsky B, Holmgren A (2006) Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res 66:4410–4418
Lu G, Xiao H, You H, Lin Y, Jin H et al (2008) Synergistic-inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin. Clin Cancer Res 14:4981–4988
Lu HF, Chen YL, Yang JS, Yang YY, Liu JY et al (2010) Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. J Agric Food Chem 58:12999–13005
Lugli E, Troiano L, Ferraresi R, Roat E, Prada N et al (2005) Characterization of cells with different mitochondrial membrane potential during apoptosis. Cytometry A 68:28–35
Luo T, Xia Z (2006) A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol. Anesth Analg 103:110–116
Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q (2014) High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med 6(222):222ra18
Macho A, Calzado MA, Munoz-Blanco J, Gomez-Diaz C, Gajate C, Mollinedo F et al (1999) Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death Differ 6:155–165
Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT et al (2009) Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med 46:672–679
Marquardt JU, Gomez-Quiroz L, Arreguin Camacho LO, Pinna F, Lee YH et al (2015) Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. J Hepatol 63:661–669
McConnell MJ, Herst PM (2014) Ascorbate combination therapy: new tool in the anticancer toolbox? Sci Transl Med 6(222):222fs6
McCormack D, McFadden D (2012) Pterostilbene and cancer: current review. J Surg Res 173:e53–e61
McNally SJ, Harrison EM, Ross JA, Garden OJ, Wigmore SJ (2007) Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int J Mol Med 19:165–172
Meira LB, Devaraj S, Kisby GE, Burns DK, Daniel RL et al (2001) Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress. Cancer Res 61:5552–5557
Mena S, Rodriguez ML, Posoda X, Estrela JM, Jaattela M et al (2012) Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane premebillization-dependent mechanism. PLoS One 7:e44524
Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, Segura-Aguilar J (1999) Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 26:107–116
Meybodi NM, Mortazavian AM, Monfared AB, Sohrabvandi S, Meybodi FA (2017) Phytochemicals in cancer prevention: a review of the evidence. Int J Cancer Manag 10:e7219
Mileo AM, Miccadei S (2016) Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies. Oxidative Med Cell Longev 2016:6475624. 17 pages
Min KJ, Kwon TK (2014) Anticancer effects and molecular mechanisms of epigallocatechin-3-gallate. Integr Med Res 3:16–24
Mohapatra P, Singh P, Singh D, Sahoo S, Sahoo SK (2022) Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective. OpenNano 7:100055
Moragoda L, Jaszewski R, Majumdar AP (2001) Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 21:873–878
Morin D, Barthelemy S, Zini R, Labidalle S, Tillement JP (2001) Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. FEBS Lett 495:131–136
Mortezaee K, Salehi E, Mirtavoos-Mahyari H, Motevaseli E, Najafi M, Farhood B et al (2019) Mechanisms of apoptosis modulation by Curcumin: implications for cancer therapy. J Cell Physiol 234:12537–12550
Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ (2002) Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int J Cancer 98:761–769
Mu C, Jia P, Yan Z, Liu X, Li X, Liu H (2007) Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods Find Exp Clin Pharmacol 29:179–183
Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597–7609
Munday R, Munday CM (2004) Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allylisothiocyanate with sulforaphane and related compounds. J Agric Food Chem 52:1867–1871
Nakamura Y, Ohigashi H, Masuda S, Murakami A, Morimitsu Y, Kawamoto Y, Osawa T, Imagawa M, Uchida K (2000) Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates. Cancer Res 60:219–225
Nakamura Y, Kawakami M, Yoshihiro A, Miyoshi N, Ohigashi H, Kawai K, Osawa T, Uchida K (2002) Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. J Biol Chem 277:8492–8499
Nakazato T, Ito K, Miyakawa Y, Kinjo K, Yamada T et al (2005) Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo. Haematologica 90:317–325
Narayanan BA, Narayanan NK, Re GG, Nixon DW (2003) Differential expression of genes induced by resveratrol in LNCaP cells: p53-mediated molecular targets. Int J Cancer 104:204–212
NavaneethaKrishnan S, Rosales JL, Lee KY (2019) ROS-mediated cancer cell killing through dietary phytochemicals. Oxid Med Cell Longev 2019:9051542. 16 pages
Nishinaka T, Ichijo Y, Ito M, Miyakawa Y, Kinjo K et al (2007) Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Toxicol Lett 170:238–247
Noda C, He J, Takano T, Tanaka C, Kondo T et al (2007) Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells. Biochem Biophys Res Commun 362:951–957
Ong JYH, Yong PVC, Lim YM, Ho ASH (2015) 2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways. Life Sci 135:158–164
Pan MH, Chang YH, Badmaev V, Nagabhushanam K, Ho CT (2007) Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells. J Agric Food Chem 55:7777–7785
Panchal HD, Vranizan K, Lee CY, Ho J, Ngai J, Timiras PS (2008) Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets. Neurochem Res 33:1701–1710
Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Med Cell Longev 2:270–278
Park W, Amin AR, Chen ZG, Shin DM (2013) New perspectives of curcumin in cancer prevention. Cancer Prev Res 6:387–400
Perez-Jimenez J, Neveu V, Vos F, Scalbert A (2010) Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. Eur J Clin Nutr 64:S112–S120
Petersen M, Simmonds MSJ (2003) Rosmarinic acid. Phyto Chem 62:121–125
Pramanik KC, Boreddy SR, Srivastava SK (2011) Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One 6:e20151
Priego S, Feddi F, Ferrer P, Mena S, Benlloch M et al (2008) Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2 and superoxide dismutase 2-dependent mechanism. Mol Cancer Ther 7:3330–3342
Psahoulia FH, Drosopoulos KG, Doubravska L, Andera L, Pintzas A (2007) Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol Cancer Ther 6:2591–2599
Qian Q, Chen W, Cao Y, Qi C, Cui Y, Li Y, Wu J (2019) Targeting reactive oxygen species in cancer via Chinese herbal medicine. Oxid Med Cell Longev 2019:9240426. 23 pages
Qin J, Xie LP, Zheng XY, Wang YB, Bai Y et al (2007) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins. Biochem Biophys Res Commun 354:852–857
Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll Z, Fite A, Zhang H et al (2007) Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo. Cancer Res 67:2141–2149
Ramos AM, Aller P (2008) Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. Biochem Pharmacol 75:1912–1923
Ramos AA, Azqueta A, Pereira-Wilson C, Collins AR (2010) Polyphenolic compounds from Salvia species protect cellular DNA from oxidation and stimulate DNA repair in cultured human cells. J Agric Food Chem 58:7465–7471
Ranjan A, Fofaria NM, Kim SH, Srivastava SK (2015) Modulation of signal transduction pathways by natural compounds in cancer. Chin J Nat Med 13:730–742
Ranjan A, Ramachandran S, Gupta N, Kaushik I, Wright S, Srivastava S et al (2019) Role of phytochemicals in cancer prevention. Int J Mol Sci 20:4981
Rather RA, Bhagat M (2018) Cancer chemoprevention and piperine: molecular mechanisms and therapeutic opportunities. Front Cell Dev Biol 2018:6. 10 pages
Rodriguez ML, Estrela JM, Ortega L (2013) Natural polyphenols and apoptosis induction in cancer therapy. J Carcinogene Mutagene 2013:S6. 10 pages
Romos S (2007) Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18:427–442
Rosa LDS, Jordão NA, Soares NDCP, DeMesquita JF, Monteiro M, Teodoro AJ (2018) Pharmacokinetic, antiproliferative and apoptotic effects of phenolic acids in human colon adenocarcinoma cells using in vitro and in silico approaches. Molecules 23:2569. 17 pages
Rossetto M, Lante A, Vanzani P, Spettoli P, Scarpa M, Rigo A (2005) Red chicories as potent scavengers of highly reactive radicals: a study on their phenolic composition and peroxyl radical trapping capacity and efficiency. J Agric Food Chem 53:8169–8175
Russell W, Duthie G (2011) Plant secondary metabolites and gut health: the case for phenolic acids. Proc Nutr Soc 70:389–396
Russell LH, Mazzio JE, Badisa RB, Zhu ZP, Agharahimi M et al (2012) Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells. Anticancer Res 32:1595–1602
Russo M, Spagnuolo C, Tedesco I, Russo GL (2010) Phytochemicals in cancer prevention and therapy: truth or dare? Toxins (Basel) 2:517–551
Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H (2010) New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev Res (Phila) 3:953–962
Sahu RP, Zhang R, Batra S, Shi Y, Srivastava SK (2009a) Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. Carcinogenesis 30:1744–1753
Sahu RP, Epperly MW, Srivastava SK (2009b) Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation therapy. Front Biosci 1:568–576
Sahu RP, Batra S, Srivastava SK (2009c) Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer 100:1425–1433
Sakagami H, Arakawa H, Maeda M, Satoh K, Kadofuku T, Fukuchi K, Gomi K (2001) Production of hydrogen peroxide and methionine sulfoxide by epigallocatechingallate and antioxidants. Anticancer Res 21:2633–2641
Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M et al (2018) Resveratrol: a double-edged sword in health benefits. Biomedicine 6:91
Salim EI, Fukushima S (2003) Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer 45:195–202
Sarkar FH, Li Y (2009) Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treatment Rev 35:597–607
Sarkar FH, Li Y, Wang Z, Kong D (2009) Cellular signaling perturbation by natural products. Cell Signal 21:1541–1547
Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO (2014) Antioxidants accelerate lung cancer progression in mice. Sci Transl Med 6:221
Sazuka M, Murakami S, Isemura M, Satoh K, Nukiwa T (1995) Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells. Cancer Lett 98:27–31
Schneider JG, Alosi JA, McDonald DE, McFadden DW (2010) Pterostilbene inhibits lung cancer through induction of apoptosis. J Surg Res 161:18–22
Seidel C, Schnekenburger M, Dicato M, Diederich M (2014) Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases. Cancer Lett 343:134–146
Seo YR, Sweeney C, Smith ML (2002a) Selenomethionine induction of DNA repair response in human fibroblasts. Oncogene 21:3663–3669
Seo YR, Kelley MR, Smith ML (2002b) Selenomethionine regulation of p53 by a Ref1-dependent redox mechanism. Proc Natl Acad Sci U S A 99:14548–14553
Seo KH, Ryu HW, Park KH, Kim JH, Mangosenone FA (2015) Furanoxanthone from Garciana mangostana, induces reactive oxygen species-mediated apoptosis in lung cancer cells and decreases Xenograft tumor growth. Phytother Res 29:1753–1760
Shahidi F, Janitha PK, Wanasundara PD (1992) Phenolic antioxidants. Crit Rev Food Sci Nutr 32:67–103
Shankar S, Srivastava RK (2007) Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa. Carcinogenesis 28:1277–1286
Shankar S, Chen Q, Sarva K, Siddiqui I, Srivastava RK (2007a) Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal 2:10. 14 pages
Shankar S, Chen Q, Siddiqui I, Sarva K, Srivastava RK (2007b) Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4′, 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential. J Mol Signal 2:7. 17 pages
Shankar S, Suthakar G, Srivastava RK (2007c) Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. Front Biosci 12:5039–5051
Sharma SH, Rajamanickam V, Nagarajan S (2018) Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. Chem Biol Interact 291:16–28
Sharoni Y, Danilenko M, Levy J (2000) Molecular mechanisms for the anticancer activity of the carotenoid lycopene. Drug Dev Res 50:448–456
Sharoni Y, Danilenko M, Walfisch S, Amir H, Nahum A, Bendor A et al (2002) Role of gene regulation in the anti-cancer activity of carotenoied. Pure Appl Chem 74:1469–1477
Shen G, Xu C, Hu R, Jain MR, Nair S, Lin W et al (2005) Comparison of (−)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (−/−) mice. Pharm Res 22:1805–1820
Shen G, Xu C, Chen C, Hebbar V, Kong AN (2006) p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. Cancer Chemother Pharmacol 57:317–327
Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PSSR (2007) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64:353–356
Shukla Y, Kalra N (2007) Cancer chemoprevention with garlic and its constituents. Cancer Lett 247:167–181
Siddiqui IA, Malik A, Adhami VM, Asim M, Hafeez BB et al (2008) Green tea polyphenol EGCG sensitizes human prostrate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene 27:2055–2063
Siddiqui S, Ahamad MS, Jafri A, Afzal M, Arshad M (2017) Piperine triggers apoptosis of human oral squamous carcinoma through cell cycle arrest and mitochondrial oxidative stress. Nutr Cancer 69:791–799
Silva JP, Gomes AC, Coutinho OP (2008) Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells. Eur J Pharmacol 601:50–60
Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL et al (2005) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem 280:19911–19924
Singh N, Nigam M, Ranjan V, Sharma R, Balapure AK et al (2009) Caspase mediated enhanced apoptotic action of cyclophosphamide- and resveratrol-treated MCF-7 cells. J Pharmacol Sci 109:473–485
Singh BN, Shankar S, Srivastava RK (2011) Green tea catchin, epigallocatechin-3-gallate (EGCG) mechanisms, perspectives and clinical applications. Biochem Pharmacol 82:1807–1821
Singh M, Bhui K, Singh R, Shukla Y (2013) Tea polyphenols enhance cisplatin chemosensitivity in cervical cancer cells via induction of apoptosis. Life Sci 93:7–16
Singh SK, Banerjee S, Acosta EP, Lillard JW, Singh R (2017) Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Oncotarget 8:17216–17228
Singh D, Khan MA, Siddique HR (2019) Apigenin, a plant flavone playing noble roles in cancer prevention via modulation of key cell signaling networks. Recent Pat Anticancer Drug Discov 14:298–311
Singh D, Gupta M, Sarwat M, Siddique HR (2022) Apigenin in cancer prevention and therapy: a systematic review and meta-analysis of animal models. Crit Rev Oncol Hematol 176:103751
Singh-Gupta V, Zhang H, Banerjee S, Kong D, Raffoul JJ, Sarkar FH et al (2009) Radiation induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer 124:1675–1684
Singh-Gupta V, Zhang H, Yunker CK, Ahmad Z, Zwier D, Sarkar FH et al (2010) Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy. Pharm Res 27:1115–1127
Singh-Gupta V, Joiner MC, Runyan L, Yunker CK, Sarkar FH, Miller S et al (2011) Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. J Thorac Oncol 6:688–698
Song Y, Sun H, Zhang A, Yan G, Han Y, Wang X (2014) Plant-derived natural products as leads to anti-cancer drugs. J Med Plant Herbal Ther Res 2:6–15
Sparnins VL, Barany G, Wattenberg LW (1988) Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis 9:131–134
Spencer JP, Abd El Mohsen MM, Minihane AM, Mathers JC (2008) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr 99:12–22
Sreejayan M, Rao N (1997) Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol 49:105–107
Sriram N, Kalayarasan S, Sudhandiran G (2009) Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling. Pulm Pharmacol Ther 22:221–236
Stoner GD, Mukhtar H (1995) Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl 22:169–180
Su CC, Lin JG, Li TM, Chung JG, Yang JS, Ip SW et al (2006) Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of R.O.S., Ca2+ and the activation of caspase-3. Anticancer Res 26:4379–4389
Subramanian AP, John AA, Vellayappan MV, Balaji A, Jaganathan SK, Supriyanto E et al (2015) Gallic acid: Prospects and molecular mechanisms of its anticancer activity. RSC Adv 5:35608–35621
Sun C, Hu Y, Liu X, Wu T, Wang Y et al (2006) Resveratrol downregulates the constitutional activation of nuclear factor-kappaB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle and induction of apoptosis. Cancer Genet Cytogenet 165:9–19
Sznarkowska A, Kostecka A, Meller K, Bielawski KP (2017) Inhibition of cancer antioxidant defense by natural compounds. Oncotarget 8:15996–16016
Talalay P, Fahey JW (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr 131:3027S–3033S
Tang L, Zirpoli GR, Guru K, Moysich KB, Zhang Y et al (2010) Intake of cruciferous vegetables modifies bladder cancer survival. Cancer Epidemiol Biomark Prev 19:1806–1811
Thawonsuwan J, Kiron V, Satoh S, Panigrahi A, Verlhac V (2010) Epigallocatechin-3-gallate (EGCG) affects the antioxidant and immune defense of the rainbow trout, Oncorhynchus mykiss. Fish Physiol Biochem 36:687–697
Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S (2008) Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic Biol Med 45:1403–1412
Tolomeo M, Grimaudo S, DiCristina A, Roberti M, Pizzirani D et al (2005) Plerostilbene and 3-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. Int J Biochem Cell Biol 17:1709–1726
Totta P, Acconcia F, Leone S, Cardillo I, Marino M (2004) Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor α and β signalling. IUBMB Life 56:491–499
Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H et al (2006) Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethylisothiocyanate. Cancer Cell 10:241–252
Urbina-Cano P, Bobadilla-Morales I, Ramirez-Herrera MA et al (2006) DNA damage in mouse lymphocytes exposed to curcumin and copper. J Appl Genet 47:377–382
Valdez-Morales M, Espinosa-Alonso LG, Espinoza-Torres LC, Delgado-Vargas F, Medina-Godoy S (2014) Phenolic content and antioxidant and antimutagenic activities in tomato peel, seeds, and byproducts. J Agric Food Chem 62:5281–5289
Valerio LG, Kepa JK, Pickwell GV, Quattrochi LC (2001) Induction of human NAD(P)H: quinoneoxidoreductase (NQO1) gene expression by the flavonolquercetin. Toxicol Lett 119:49–57
Varoni EM, Lo Faro AF, Sharifi-Rad J, Iriti M (2016) Anticancer molecular mechanisms of resveratrol. Front Nutr 3:8. 15 pages
Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, Nagini S (2010) The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol 649:84–91
Wang IK, Lin-Shiau SY, Lin JK (1999) Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 35:1517–1525
Wang Y, Raffoul JJ, Che M, Doerge DR, Joiner MC, Kucuk O et al (2006) Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model. Radic Res 166:73–80
Wang LC, Chu KH, Liang YC, Lin YL, Chiang BL (2010) Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells. Clin Exp Immunol 160:223–232
Wang H, Khor TO, Shu L, Su Z, Fuentes F, Lee JH, Kong ANT (2012) Plants against cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anti Cancer Agents Med Chem 12:1281–1305
Wang Y, Wei S, Wang J, Fang Q, Chai Q (2014) Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspases. Mol Med Rep 10:543–549
Wang J, Luo B, Li X, Lu WN, Yang J et al (2017) Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells. Cell Death Dis 8:e2887
Warkad MS, Kim CH, Kang BG, Park SH, Jung JS, Feng JH et al (2021) Metformin-induced R.O.S. upregulation as amplified by Apigenin causes profound anticancer activity while sparing normal cells. Sci Rep 11:14002
Watson J (2013) Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol 3:120144. 9 pages
Watson JL, Hill R, Yaffe PB, Greenshields A, Walsh M et al (2010) Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. Cancer Lett 297:1–8
Whitlock NC, Baek SJ (2012) The anticancer effects of resveratrol: modulation of transcription factors. Nutr Cancer 64:493–502
Wicker CA, Sahu RP, Kulkarni-Datar K, Srivastava SK, Brown TL (2010) BITC sensitizes pancreatic adenocarcinomas to TRAIL-induced apoptosis. Cancer Growth Metastasis 2009:45–55
Wu CC, Hsu MC, Hsieh CW, Lin JB, Lai PH, Wung BS (2006) Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci 78:2889–2897
Wu PP, Kuo SC, Huang WW, Yang JS, Lai KC et al (2009) Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway. Anticancer Res 29:1435–1442
Wu B, Yao H, Wang S, Xu R (2013) DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-kB and caspase-3 activation. Biochem Biophys Res Commun 434:75–80
Xiao D, Vogel V, Singh SV (2006) Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol Cancer Ther 5:2931–2945
Xiao D, Powolny AA, Moura MB, Kelley EE, Bommareddy A et al (2010) Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J Biol Chem 285:26558–26569
Xie X, Yin J, Jia Q, Wang J, Zou C et al (2011) Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncol Rep 26:687–693
Xu K, Thornalley PJ (2001) Signal transduction activated by the cancer chemopreventiveisothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK. Br J Cancer 84:670–673
Xu C, Shen G, Chen C, Gelinas C, Kong AN (2005) Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene 24:4486–4495
Xu C, Huang MT, Shen G, Yuan X, Lin W, Khor TO et al (2006a) Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer Res 66:8293–8296
Xu C, Yuan X, Pan Z, Shen G, Kim JH, Yu S et al (2006b) Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol Cancer Ther 5:1918–1926
Yan X, Qi M, Li P, Zhan Y, Shao H (2017) Apigenin in cancer therapy: anticancer effects and mechanisms of action. Cell Biosci 7:50
Yang CS, Yang GY, Landau JM, Kim S, Liao J (1998) Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis and tumor progression. Exp Lung Res 24:629–639
Yang GY, Liao J, Li C, Chung J, Yurkow EJ, Ho CT, Yang CS (2000) Effect of black and green tea polyphenols on c-jun phosphorylation and H2O2 production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 21:2035–2039
Yang CS, Chhabra SK, Hong JY, Smith TJ (2001) Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J Nutr 131:1041S–1045S
Yang S, Irani K, Heffron SE, Jurnak F, MeyskensJr FL (2005) Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor. Mol Cancer Ther 4:1923–1935
Yang JH, Hsia TC, Kuo HM, Chao PDL, Chou CC et al (2006) Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos 34:296–304
Yang J, Ning J, Peng L, He D (2015) Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer. Int J Clin Exp Pathol 8:9272–9278
Yang X, Li Z, Wu Q, Chen S, Yi C, Gong C (2017) TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors. Drug Deliv 24:1526–1536
Ye L, Zhang Y (2001) Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of phase 2 detoxification enzymes. Carcinogenesis 22:1987–1992
Yeh YT, Yeh H, Su SH, Lin JS, Lee KJ et al (2014) Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations. Free Radic Biol Med 74:1–13
Yin F, Giuliano AE, van Herle AJ (1999) Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). Anticancer Res 19:4297–4303
Yin MC, Lin CC, Wu HC, Tsao SM, Hsu CK (2009) Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action. J Agric Food Chem 57:6468–6473
You BR, Kim SZ, Kim SH, Park WH (2011) Gallic acid-induced lung cancer cell death is accompanied by ROS increase and glutathione depletion. Mol Cell Biochem 357:295–303
Yu R, Mandlekar S, Harvey KJ, Ucker DS, Kong ANT (1998) Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res 58:402–408
Yu R, Lei W, Mandlekar S, Weber MJ, Der CJ, Wu J, Kong AN (1999) Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. J Biol Chem 274:27545–27552
Yu H, Pan C, Zhao S, Wang Z, Zhang H et al (2008) Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother 62:366–372
Yu J, Zhou X, He X, Dai M, Zhang Q (2011) Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells. Asian Pac J Cancer Prev 12:1925–1929
Yuan ZP, Chen LJ, Fan LY, Tang MH, Yang GL et al (2006) Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin Cancer Res 12:3193–3199
Zhang Y, Talalay P (1998) Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes. Cancer Res 58:4632–4639
Zhang Y, Talalay P, Cho CG, Posner GH (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A 89:2399–2403
Zhang S, Cao HJ, Davis FB, Tang HY, Davis PJ et al (2004) Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer 91:178–185
Zhang R, Loganathan S, Humphreys I, Srivastava SK (2006) Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells. J Nutr 136:2728–2734
Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK (2008) In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 13:1465–1478
Zhang Q, Zhao XH, Wang ZJ (2009) Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro 23:797–807
Zhang X, Huang J, Yu C, Xiang L, Li L, Shi D, Lin F (2020) Quercetin enhanced paclitaxel therapeutic effects towards PC-3 prostate cancer through ER stress induction and ROS production. OncoTargets Ther 13:513–523
Zhao CR, Gao ZH, Qu XJ (2010) Nrf2–ARE signaling pathway and natural products for cancer chemoprevention. Cancer Epidemiol 34:523–533
Zhu Y, Zhuang JX, Wang Q, Zhang HY, Yang P (2013) Inhibitory effect of benzyl isothiocyanate on proliferation in vitro of human glioma cells. Asian Pac J Cancer Prev 14:2607–2610
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Bansal, M.P. (2023). ROS/Redox Regulation with Dietary Phytochemicals and Role in Anticancer Activity. In: Redox Regulation and Therapeutic Approaches in Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-99-7342-2_3
Download citation
DOI: https://doi.org/10.1007/978-981-99-7342-2_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-7341-5
Online ISBN: 978-981-99-7342-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)