Abstract
Drug delivery research is advancing day by day due to the advancement of science and technology, which helps cure many diseases. Traditionally, drugs are administered to the body either orally or through injections. It is imperative to take several factors into account when delivering a specific drug with pharmacologically active ingredients. These factors include the drug’s cellular efficiency, pharmacokinetics, therapeutic efficiency, cellular uptake, and its effect on metabolism, exercise, and cellular toxicity. The use of biomaterials can enhance both injectable and oral drug delivery, as well as ocular, pulmonary, nasal, and transdermal drug delivery. Metals, glass, ceramics, and oscular are examples of biomaterials used in drug delivery. These materials can also be found in orthopedic devices, contact lenses, heart valves, and pacemakers. Biomaterials are categorized as either naturally driven or synthetically driven. It is most common to use synthetically driven polymers for drug delivery systems. As the polymeric drug is inoculated inside the body, its morphology changes from a sol to a gel. It is imperative to note that these gel formulations react differently to temperature, ultraviolet irradiation, ions, and pH changes. This book chapter presents a comprehensive analysis of polymeric systems used in drug delivery, their types, formulations, advancements, and drawbacks.
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References
Adeosun SO, Ilomuanya MO, Gbenebor OP, Dada MO, Odili CC (2020) Biomaterials for drug delivery: sources, classification, synthesis, processing, and applications. In: Advanced functional materials, pp 1–25
Agrawal AK, Das M, Jain S (2012) In situ gel systems as ‘smart’ carriers for sustained ocular drug delivery. Expert Opin Drug Deliv 9(4):383–402. https://doi.org/10.1517/17425247.2012.665367
Akiyoshi K et al (1998) Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. J Control Release 54(3):313–320. https://doi.org/10.1016/S0168-3659(98)00017-0
Amiri MS, Mohammadzadeh V, Yazdi MET, Barani M, Rahdar A, Kyzas GZ (2021) Plant-based gums and mucilages applications in pharmacology and nanomedicine: a review. Molecules 26(6):1–23. https://doi.org/10.3390/molecules26061770
Attia MF, Anton N, Wallyn J, Omran Z, Vandamme TF (2019) An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J Pharm Pharmacol 71(8):1185–1198. Wiley. https://doi.org/10.1111/jphp.13098.
Azizi S, Mohamad R, Abdul Rahim R, Mohammadinejad R, Bin Ariff A (2017) Hydrogel beads bio-nanocomposite based on Kappa-Carrageenan and green synthesized silver nanoparticles for biomedical applications. Int J Biol Macromol 104:423–431. https://doi.org/10.1016/j.ijbiomac.2017.06.010
Bahrami N, Nouri Khorasani S, Mahdavi H, Ghiaci M, Mokhtari R (2019) Low-pressure plasma surface modification of polyurethane films with chitosan and collagen biomolecules. J Appl Polym Sci 136(21). https://doi.org/10.1002/APP.47567
Barclay TG, Day CM, Petrovsky N, Garg S (2019) Review of polysaccharide particle-based functional drug delivery. Carbohydr Polym 221:94–112. NIH Public Access. https://doi.org/10.1016/j.carbpol.2019.05.067
Belda Marín C, Fitzpatrick V, Kaplan DL, Landoulsi J, Guénin E, Egles C (2020) Silk polymers and nanoparticles: a powerful combination for the design of versatile biomaterials. Front Chem 8:1–22. https://doi.org/10.3389/fchem.2020.604398
Benny IS, Gunasekar V, Ponnusami V (2014) Review on application of Xanthan gum in drug delivery. Int J Pharmtech Res 6(4):1322–1326
Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R (2004) Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharmaceut Biopharmaceut 57(1):19–34. Elsevier. https://doi.org/10.1016/S0939-6411(03)00161-9
Bos GW et al (2005) Tissue reactions of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats. Biomaterials 26(18):3901–3909. https://doi.org/10.1016/j.biomaterials.2004.10.008
Cabral JD et al (2015) Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention. J. Biomed. Mater. Res. Part A 103(8):2611–2620. https://doi.org/10.1002/jbm.a.35395
Calzoni E, Cesaretti A, Polchi A, Di Michele A, Tancini B, Emiliani C (2019) Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies. J Funct Biomater 10(1):1–15. MDPI AG. https://doi.org/10.3390/jfb10010004
Chen G, Kawazoe N, Tateishi T (2008) Collagen-based scaffolds for tissue engineering. In: Natural-based polymers for biomedical applications. Woodhead Publishing, pp 396–415
Cheng Z, Li M, Dey R, Chen Y (2021) Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol 14(1):1–27. https://doi.org/10.1186/s13045-021-01096-0
Cheng C, Meng Y, Zhang Z, Chen J, Zhang Q (2019) Imine bond- and coordinate bond-linked pH-sensitive cisplatin complex nanoparticles for active targeting to tumor cells. J Nanosci Nanotechnol 19(6):3277–3287. https://doi.org/10.1166/jnn.2019.16314
Cheng G et al (2022) Anti-Parkinsonian therapy: strategies for crossing the blood–brain barrier and nano-biological effects of nanomaterials. 14(1). Springer Singapore
Chhetri P, Chakraborty P, Das D, Afnan T (2021) In-situ forming polymeric drug delivery systems for ophthalmic use: an overview. J Drug Deliv Ther 11(3-S):98–103. https://doi.org/10.22270/jddt.v11i3-s.4874
Choukaife H, Seyam S, Alallam B, Doolaanea AA, Alfatama M (2022) Current advances in chitosan nanoparticles based oral drug delivery for colorectal cancer treatment. Int J Nanomed 17:3933–3966. https://doi.org/10.2147/IJN.S375229
Ciobanu BC, Cadinoiu AN, Popa M, Desbrières J, Peptu CA (2014) Modulated release from liposomes entrapped in chitosan/gelatin hydrogels. Mater Sci Eng C 43:383–391. https://doi.org/10.1016/j.msec.2014.07.036
Das M, Giri TK (2020) Hydrogels based on gellan gum in cell delivery and drug delivery. J Drug Deliv Sci Technol 56:101586. https://doi.org/10.1016/j.jddst.2020.101586
Dattilo M, Patitucci F, Prete S, Parisi OI, Puoci F (2023) Polysaccharide-based hydrogels and their application as drug delivery systems in cancer treatment: a review. J Funct Biomater 14(2):55. Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/jfb14020055
de Guzman RC, Rabbany SY (2016) PEG-immobilized keratin for protein drug sequestration and pH-mediated delivery. J Drug Deliv 2016:1–9. https://doi.org/10.1155/2016/7843951
Debabrata GD, Chakrabarti G (2018) Thermoresponsive drug delivery systems, characterization and application. In: Applications of targeted nano drugs and delivery systems: nanoscience and nanotechnology in drug delivery. Elsevier, pp 133–155
Del Valle LJ, Díaz A, Puiggalí J (2017) Hydrogels for biomedical applications: cellulose, chitosan, and protein/peptide derivatives. Gels 3(3):1–28. https://doi.org/10.3390/gels3030027
Diller RB, Tabor AJ (2022) The role of the extracellular matrix (ECM) in wound healing: a review. Biomimetics 7(3):14–16. https://doi.org/10.3390/biomimetics7030087
Dowling MB, Lee JH, Raghavan SR (2009) pH-responsive jello: gelatin gels containing fatty acid vesicles. Langmuir 25(15):8519–8525. https://doi.org/10.1021/la804159g
Eliaz N, Metoki N (2017) Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials (Basel) 10(4). https://doi.org/10.3390/ma10040334
Feigin VL et al (2019) Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(5):459–480. https://doi.org/10.1016/S1474-4422(18)30499-X
Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R (2018) Advances in biomaterials for drug delivery. Adv Mater 30(29). Wiley-VCH Verlag. https://doi.org/10.1002/adma.201705328
Feroz S, Muhammad N, Ranayake J, Dias G (2020) Keratin-based materials for biomedical applications. Bioactive Mater 5(3):496–509. Elsevier. https://doi.org/10.1016/j.bioactmat.2020.04.007
Ferroni C, Varchi G (2021) Keratin-based nanoparticles as drug delivery carriers. Appl Sci (Switz) 11(20):9417. Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/app11209417
Foox M, Zilberman M (2015) Drug delivery from gelatin-based systems. Expert Opin Drug Deliv 12(9):1547–1563. https://doi.org/10.1517/17425247.2015.1037272
Gila-Vilchez C et al (2022) Biocompatible short-peptides fibrin co-assembled hydrogels. ACS Appl Polym Mater. https://doi.org/10.1021/ACSAPM.2C02164/SUPPL_FILE/AP2C02164_SI_002.MP4
Grijalvo S, Mayr J, Eritja R, Díaz DD (2016) Biodegradable liposome-encapsulated hydrogels for biomedical applications: a marriage of convenience. Biomater Sci 4(4):555–574. https://doi.org/10.1039/c5bm00481k
Gu J et al (2008) pH-triggered reversible ‘stealth’ polycationic micelles. Biomacromolecules 9(1):255–262. https://doi.org/10.1021/bm701084w
Gu X et al (2013) Temperature-responsive drug delivery systems based on polyaspartamides with isopropylamine pendant groups. Soft Matter 9(30):7267–7273. https://doi.org/10.1039/c3sm50904d
Gu Z et al (2013) Injectable nano-network for glucose-mediated insulin delivery. ACS Nano 7(5):4194–4201. https://doi.org/10.1021/nn400630x
Guo X, Cheng Y, Zhao X, Luo Y, Chen J, Yuan WE (2018) Advances in redox-responsive drug delivery systems of tumor microenvironment. J Nanobiotechnol 16(1):1–10. BioMed Central Ltd. https://doi.org/10.1186/s12951-018-0398-2
Gupta S, Archana, Niranjan AK (2022) A comprehensive review on in-situ gel drug delivery system. J Drug Deliv Ther 12(4-S):245–248. https://doi.org/10.22270/jddt.v12i4-s.5539
Ha CS, Gardella JA (2005) Surface chemistry of biodegradable polymers for drug delivery systems. Chem Rev 105(11):4205–4232. https://doi.org/10.1021/CR040419Y/ASSET/CR040419Y.FP.PNG_V03
Han X et al (2022) Biomaterial-assisted biotherapy: a brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy. Bioactive Mater 17:29–48. KeAi Communications Co. https://doi.org/10.1016/j.bioactmat.2022.01.011
Hezaveh H, Muhamad II (2012) The effect of nanoparticles on gastrointestinal release from modified κ-carrageenan nanocomposite hydrogels. Carbohydr Polym 89(1):138–145. https://doi.org/10.1016/j.carbpol.2012.02.062
How KN, Yap WH, Lim CLH, Goh BH, Lai ZW (2020) Hyaluronic acid-mediated drug delivery system targeting for inflammatory skin diseases: a mini review. Front Pharmacol 11:1105. Frontiers Media S.A. https://doi.org/10.3389/fphar.2020.01105
Hu Q, Katti PS, Gu Z (2014) Enzyme-responsive nanomaterials for controlled drug delivery. Nanoscale 6(21):12273–12286. https://doi.org/10.1039/c4nr04249b
Huang G, Huang H (2018a) Application of hyaluronic acid as carriers in drug delivery. Drug Deliv 25(1):766–772. https://doi.org/10.1080/10717544.2018.1450910
Huang G, Huang H (2018b) Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system. J Control Release 278:122–126. Elsevier. https://doi.org/10.1016/j.jconrel.2018.04.015
Hurler J, Berg OA, Skar M, Conradi AH, Johnsen PJ, Škalko-Basnet N (2012) Improved burns therapy: liposomes-in-hydrogel delivery system for mupirocin. J Pharm Sci 101(10):3906–3915. https://doi.org/10.1002/jps.23260
Jain NK, Tare MS, Mishra V, Tripathi PK (2015) The development, characterization and in vivo anti-ovarian cancer activity of poly(propylene imine) (PPI)-antibody conjugates containing encapsulated paclitaxel. Nanomed Nanotechnol Biol Med 11(1):207–218. https://doi.org/10.1016/j.nano.2014.09.006
Jiann Chong ET, Ng JW, Lee P-C (2022) Classification and medical applications of biomaterials—a mini review. Bio Integr. https://doi.org/10.15212/bioi-2022-0009
Jumelle C, Gholizadeh S, Annabi N, Dana R (2020) Advances and limitations of drug delivery systems formulated as eye drops. J Control Release 321:1–22. Elsevier. https://doi.org/10.1016/j.jconrel.2020.01.057
Karandish F et al (2016) Prostate-specific membrane antigen targeted polymersomes for delivering mocetinostat and docetaxel to prostate cancer cell spheroids. ACS Omega 1(5):952–962. https://doi.org/10.1021/acsomega.6b00126
Karimi M et al (2016) Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances. ACS Appl Mater Interfaces 8(33):21107–21133. NIH Public Access. https://doi.org/10.1021/acsami.6b00371
Kedir WM, Deresa EM, Diriba TF (2022) Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites. Heliyon 8(9):e10654. https://doi.org/10.1016/j.heliyon.2022.e10654
Kim JK, Kim HJ, Chung JY, Lee JH, Young SB, Kim YH (2014) Natural and synthetic biomaterials for controlled drug delivery. Arch Pharm Res 37(1):60–68. https://doi.org/10.1007/s12272-013-0280-6
Konop M, Rybka M, Drapała A (2021) Keratin biomaterials in skin wound healing, an old player in modern medicine: a mini review. Pharmaceutics 13(12). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/pharmaceutics13122029
Lara-Velazquez M et al (2020) Chitosan-based non-viral gene and drug delivery systems for brain cancer. Front Neurol 11. https://doi.org/10.3389/fneur.2020.00740
Leach JB, Schmidt CE (2005) Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds. Biomaterials 26(2):125–135. https://doi.org/10.1016/j.biomaterials.2004.02.018
Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37(1):106–126. https://doi.org/10.1016/j.progpolymsci.2011.06.003
Lee JH, Oh H, Baxa U, Raghavan SR, Blumenthal R (2012) Biopolymer-connected liposome networks as injectable biomaterials capable of sustained local drug delivery. Biomacromolecules 13(10):3388–3394. https://doi.org/10.1021/bm301143d
Lee H et al (2015) Erratum to: human hair keratin-based BioFilm for potent application to periodontal tissue regeneration [23(3):300–308 (2015)], Macromol Res 23(9):885. Polymer Society of Korea. https://doi.org/10.1007/s13233-015-3201-3
Lemos PVF, Marcelino HR, Cardoso LG, de Souza CO, Druzian JI (2021) Starch chemical modifications applied to drug delivery systems: from fundamentals to FDA-approved raw materials. Int J Biol Macromol 184:218–234. https://doi.org/10.1016/j.ijbiomac.2021.06.077
Leong KH, Chung LY, Noordin MI, Onuki Y, Morishita M, Takayama K (2011) Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery. Carbohydr Polym 86(2):555–565. https://doi.org/10.1016/j.carbpol.2011.04.070
Li J et al (2018) Chitosan-based nanomaterials for drug delivery. Molecules 23(10):1–26. https://doi.org/10.3390/molecules23102661
Li R, Peng F, Cai J, Yang D, Zhang P (2020a) Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects. Asian J Pharmaceut Sci 15(3):311–325. Elsevier. https://doi.org/10.1016/j.ajps.2019.06.003
Li C, Sun W, Lu Z, Ao X, Li S (2020b) Ceramic nanocomposite membranes and membrane fouling: a review. Water Res 175. Elsevier Ltd. https://doi.org/10.1016/j.watres.2020.115674
Liechty WB, Kryscio DR, Slaughter BV, Peppas NA (2010) Polymers for drug delivery systems. Annu Rev Chem Biomol Eng 1:149–173. https://doi.org/10.1146/annurev-chembioeng-073009-100847
Lohani A, Singh G, Bhattacharya SS, Rama Hegde R, Verma A (2016) Tailored-interpenetrating polymer network beads of κ-carrageenan and sodium carboxymethyl cellulose for controlled drug delivery. J Drug Deliv Sci Technol 31:53–64. https://doi.org/10.1016/j.jddst.2015.11.005
Luo Z et al (2019) Light-induced redox-responsive smart drug delivery system by using selenium-containing polymer@MOF shell/core nanocomposite. Adv Healthc Mater 8(15):1900406. https://doi.org/10.1002/adhm.201900406
Ma X et al (2012) A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging. Nano Res 5(3):199–212. https://doi.org/10.1007/s12274-012-0200-y
Magadala P, Amiji M (2008) Epidermal growth factor receptor-targeted gelatin-based engineered nanocarriers for DNA delivery and transfection in human pancreatic cancer cells. AAPS J 10(4):565–576. https://doi.org/10.1208/s12248-008-9065-0
Milivojevic M, Pajic-Lijakovic I, Bugarski B, Nayak AK, Hasnain MS (2019) Gellan gum in drug delivery applications. Elsevier Inc.
Misbah M et al (2021) Clinical pharmacology & biopharmaceutics rectal drug delivery system: an overview. Clin Pharmacol Biopharm 10(5)
Miyazaki S, Suisha F, Kawasaki N, Shirakawa M, Yamatoya K, Attwood D (1998) Thermally reversible xyloglucan gels as vehicles for rectal drug delivery. J Control Release 56(1–3):75–83. https://doi.org/10.1016/S0168-3659(98)00079-0
Moinuddin S et al (2019) Nasal drug delivery system: a innovative approach. Pharma Innov J 8(3):169–177. www.thepharmajournal.com
Nappini S, Fogli S, Castroflorio B, Bonini M, Baldelli Bombelli F, Baglioni P (2016) Magnetic field responsive drug release from magnetoliposomes in biological fluids. J Mater Chem B 4(4):716–725. https://doi.org/10.1039/c5tb02191j
Niu Y, Yuan X, Zhao Y, Zhang W, Ren L (2017) Temperature and pH dual-responsive supramolecular polymer hydrogels hybridized with functional inorganic nanoparticles. Macromol Chem Phys 218(9):1600540. https://doi.org/10.1002/macp.201600540
Noori A, Ashrafi SJ, Vaez-Ghaemi R, Hatamian-Zaremi A, Webster TJ (2017) A review of fibrin and fibrin composites for bone tissue engineering. Int J Nanomed 12:4937–4961. Dove Press. https://doi.org/10.2147/IJN.S124671
Numata K, Kaplan DL (2010) Silk-based delivery systems of bioactive molecules. Adv Drug Deliv Rev 62(15):1497–1508. https://doi.org/10.1016/j.addr.2010.03.009
Oechsle AM, Häupler M, Weigel F, Gibis M, Kohlus R, Weiss J (2016) Modulation of extruded collagen films by the addition of co-gelling proteins. J Food Eng 171:164–173. https://doi.org/10.1016/j.jfoodeng.2015.10.004
Ong W, Yang Y, Cruciano AC, McCarley RL (2008) Redox-triggered contents release from liposomes. J Am Chem Soc 130(44):14739–14744. https://doi.org/10.1021/ja8050469
Onofre-Cordeiro NA et al (2018) Agarose-silver particles films: effect of calcium ascorbate in nanoparticles synthesis and film properties. Int J Biol Macromol 119:701–707. https://doi.org/10.1016/j.ijbiomac.2018.07.115
Padhi JR, Nayak D, Nanda A, Rauta PR, Ashe S, Nayak B (2016) Development of highly biocompatible Gelatin & i-Carrageenan based composite hydrogels: in depth physiochemical analysis for biomedical applications. Carbohydr Polym 153:292–301. https://doi.org/10.1016/j.carbpol.2016.07.098
Pankaew P, Klumdoung P, Naemchanthara K (2015) A study of the preparation of silk sericin/chitosan composite film for future wound dressing applications. Appl Mech Mater 804:179–182. https://doi.org/10.4028/www.scientific.net/amm.804.179
Peng YY, Glattauer V, Ramshaw JAM (2017) Stabilisation of collagen sponges by glutaraldehyde vapour crosslinking. Int J Biomater 2017. https://doi.org/10.1155/2017/8947823
Phromsopha T, Baimark Y (2014) Preparation of starch/gelatin blend microparticles by a water-in-oil emulsion method for controlled release drug delivery. Int J Biomater 2014. https://doi.org/10.1155/2014/829490
Qian B, Zhao Q, Ye X (2020) Ultrasound and magnetic responsive drug delivery systems for cardiovascular application. J Cardiovasc Pharmacol 76(4):414–426. https://doi.org/10.1097/FJC.0000000000000885
Qureshi D, Nayak SK, Maji S, Kim D, Banerjee I, Pal K (2019) Carrageenan: a wonder polymer from marine algae for potential drug delivery applications. Curr Pharm Des 25(11):1172–1186. https://doi.org/10.2174/1381612825666190425190754
Rahman HS et al (2020) Novel drug delivery systems for loading of natural plant extracts and their biomedical applications. Int J Nanomed 15:2439–2483. https://doi.org/10.2147/IJN.S227805
Saeed RM, Dmour I, Taha MO (2020) Stable chitosan-based nanoparticles using polyphosphoric acid or hexametaphosphate for tandem ionotropic/covalent crosslinking and subsequent investigation as novel vehicles for drug delivery. Front Bioeng Biotechnol 8:1–21. https://doi.org/10.3389/fbioe.2020.00004
Sahithi B, Ansari SK, Hameeda SK, Sahithya G, Prasad DM, Lakshmi Y (2013) A review on collagen based drug delivery systems. Indian J Res Pharm Biotechnol 1:461–468
Sahoo N, Sahoo RK, Biswas N, Guha A, Kuotsu K (2015) Recent advancement of gelatin nanoparticles in drug and vaccine delivery. Int J Biol Macromol 81:317–331. Elsevier B.V. https://doi.org/10.1016/j.ijbiomac.2015.08.006
Saini M (2015) Implant biomaterials: a comprehensive review. World J Clin Cases 3(1):52. https://doi.org/10.12998/wjcc.v3.i1.52
Salati MA et al (2020) Agarose-based biomaterials: opportunities and challenges in cartilage tissue engineering. Polymers 12(5). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/POLYM12051150
Salehi S, Koeck K, Scheibel T (2020) Spider silk for tissue engineering applications. Molecules 25(3). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/molecules25030737
Salimi M, Mosca S, Gardner B, Palombo F, Matousek P, Stone N (2022) Nanoparticle-mediated photothermal therapy limitation in clinical applications regarding pain management. Nanomaterials 12(6):1–29. https://doi.org/10.3390/nano12060922
Sannino A et al (2004) Cellulose derivative-hyaluronic acid-based microporous hydrogels cross-linked through divinyl sulfone (DVS) to modulate equilibrium sorption capacity and network stability. Biomacromol 5(1):92–96. https://doi.org/10.1021/bm0341881
Santoro M, Tatara AM, Mikos AG (2014) Gelatin carriers for drug and cell delivery in tissue engineering. J Control Release 190:210–218. https://doi.org/10.1016/j.jconrel.2014.04.014
Sathuvan M et al (2017) κ-Carrageenan: an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. Carbohydr Polym 160:184–193. https://doi.org/10.1016/j.carbpol.2016.12.049
Setyawati MI, Tay CY, Bay BH, Leong DT (2017) Gold nanoparticles induced endothelial leakiness depends on particle size and endothelial cell origin. ACS Nano 11(5):5020–5030. https://doi.org/10.1021/acsnano.7b01744
Sharifianjazi F et al (2021) Polymer incorporated magnetic nanoparticles: applications for magnetoresponsive targeted drug delivery. Mater Sci Eng B Solid-State Mater Adv Technol 272:115358. Elsevier. https://doi.org/10.1016/j.mseb.2021.115358
Shevtsov M et al (2018) Targeting experimental orthotopic glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs). Int J Nanomed 13:1471–1482. https://doi.org/10.2147/IJN.S152461
Shukla SK, Mishra AK, Arotiba OA, Mamba BB (2013) Chitosan-based nanomaterials: a state-of-the-art review. Int J Biol Macromol 59:46–58. Elsevier. https://doi.org/10.1016/j.ijbiomac.2013.04.043
Singhvi G, Hans N, Shiva N, Kumar Dubey S (2019) Xanthan gum in drug delivery applications. Elsevier Inc.
Song J, Leeuwenburgh SCG (2014) Sustained delivery of biomolecules from gelatin carriers for applications in bone regeneration. Therapeut Deliv 5(8):943–958. Future Science Ltd London, UK. https://doi.org/10.4155/tde.14.42
Sood A, Gupta A, Agrawal G (2021) Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications. Carbohydr Polym Technol Appl 2:1–24. Elsevier Ltd. https://doi.org/10.1016/j.carpta.2021.100067
Sreekanth SP et al (2021) Multi-walled carbon nanotube-based nanobiosensor for the detection of cadmium in water. Environ Res 197:111148. https://doi.org/10.1016/j.envres.2021.111148
Srinivasarao DA, Lohiya G, Katti DS (2019) Fundamentals, challenges, and nanomedicine-based solutions for ocular diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol 11(4). Wiley-Blackwell. https://doi.org/10.1002/wnan.1548
Su K, Wang C (2015) Recent advances in the use of gelatin in biomedical research. Biotechnol Lett 37(11):2139–2145. https://doi.org/10.1007/s10529-015-1907-0
Su Y et al (2015) Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy. Mol Pharm 12(4):1193–1202. https://doi.org/10.1021/mp500710x
Sun W, Saldaña MDA, Zhao Y, Dong T, Jin Y, Zhang J (2016) New application of kappa-carrageenan: producing pH-sensitive lappaconitine-loaded kappa-carrageenan microparticle using two-step self-assembly. J Appl Phycol 28(3):2041–2050. https://doi.org/10.1007/s10811-015-0712-4
Sun B, Zhang M, Shen J, He Z, Fatehi P, Ni Y (2018) Applications of cellulose-based materials in sustained drug delivery systems. Curr Med Chem 26(14):2485–2501. https://doi.org/10.2174/0929867324666170705143308
Surwit EA et al (1982) Evaluation of topically applied trans-retinoic acid in the treatment of cervical intraepithelial lesions. Am J Obstet Gynecol 143(7):821–823. https://doi.org/10.1016/0002-9378(82)90016-3
Takemoto S et al (2008) Preparation of collagen/gelatin sponge scaffold for sustained release of bFGF. Tissue Eng Part A 14(10):1629–1638. https://doi.org/10.1089/ten.tea.2007.0215
Thouvenin A, Toussaint B, Marinovic J, Gilles AL, Dufaÿ Wojcicki A, Boudy V (2022) Development of thermosensitive and mucoadhesive hydrogel for buccal delivery of (S)-ketamine. Pharmaceutics 14(10). https://doi.org/10.3390/pharmaceutics14102039
Tønnesen HH, Karlsen J (2002) Alginate in drug delivery systems. Drug Dev Ind Pharm 28(6):621–630. https://doi.org/10.1081/DDC-120003853
Troy E, Tilbury MA, Power AM, Wall JG (2021) Nature-based biomaterials and their application in biomedicine. Polymers 13(19):1–37. MDPI. https://doi.org/10.3390/polym13193321
Vallet-Regí M (2022) Evolution of biomaterials. Front Mater 9:1–5. https://doi.org/10.3389/fmats.2022.864016
Vasile C, Pamfil D, Stoleru E, Baican M (2020) New developments in medical applications of hybrid hydrogels containing natural polymers. Molecules 25(7). https://doi.org/10.3390/molecules25071539
Vidya M, Rajagopal S (2021) Silk fibroin: a promising tool for wound healing and skin regeneration. Int J Polym Sci 2021. https://doi.org/10.1155/2021/9069924
Wang H, Mukherjee S, Yi J, Banerjee P, Chen Q, Zhou S (2017) Biocompatible chitosan-carbon dot hybrid nanogels for NIR-imaging-guided synergistic photothermal-chemo therapy. ACS Appl Mater Interfaces 9(22):18639–18649. https://doi.org/10.1021/acsami.7b06062
Wang YC, Wang F, Sun TM, Wang J (2011) Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjug Chem 22(10):1939–1945. https://doi.org/10.1021/bc200139n
Wang C, Willner B, Willner I (2021) Redox-responsive and light-responsive DNA-based hydrogels and their applications. React Funct Polym 166:104983. https://doi.org/10.1016/j.reactfunctpolym.2021.104983
Wang Y, Wang Z, Dong Y (2022) Collagen-based biomaterials for tissue engineering. ACS Biomater Sci Eng 9(3):1132–1150. https://doi.org/10.1021/acsbiomaterials.2c00730
Way AE, Hsu L, Shanmuganathan K, Weder C, Rowan SJ (2012) PH-responsive cellulose nanocrystal gels and nanocomposites. ACS Macro Lett 1(8):1001–1006. https://doi.org/10.1021/mz3003006
Wu J, Wei W, Wang LY, Su ZG, Ma GH (2007) A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system. Biomaterials 28(13):2220–2232. https://doi.org/10.1016/j.biomaterials.2006.12.024
Xiao F et al (2009) In vitro cyto-biocompatibility and cell detachment of temperature-sensitive dextran hydrogel. Colloids Surf B Biointerfaces 71(1):13–18. https://doi.org/10.1016/j.colsurfb.2008.12.040
Xu Q, Tanaka Y, Czernuszka JT (2007) Encapsulation and release of a hydrophobic drug from hydroxyapatite coated liposomes. Biomaterials 28(16):2687–2694. https://doi.org/10.1016/j.biomaterials.2007.02.007
Young S, Wong M, Tabata Y, Mikos AG (2005) Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 109(1–3):256–274. https://doi.org/10.1016/j.jconrel.2005.09.023
Zeplin PH, Berninger AK, Maksimovikj NC, Van Gelder P, Scheibel T, Walles H (2014) Verbesserung der Biokompatibilität von Silikonimplantaten durch Spinnenseidenbeschichtung: Immunhistochemische Untersuchungen zum Einfluss auf die Kapselbildung. Handchirurgie Mikrochirurgie Plast Chir 46(6):336–341. https://doi.org/10.1055/s-0034-1395558
Zeplin PH et al (2014) Spider silk coatings as a bioshield to reduce periprosthetic fibrous capsule formation. Adv Funct Mater 24(18):2658–2666. https://doi.org/10.1002/adfm.201302813
Zhang Y, Chan HF, Leong KW (2013) Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev 65(1):104–120. https://doi.org/10.1016/j.addr.2012.10.003
Zhang J et al (2020) Novel pH-sensitive drug-loaded electrospun nanofibers based on regenerated keratin for local tumor chemotherapy. Text Res J 90(19–20):2336–2349. https://doi.org/10.1177/0040517520919920
Zhang MX et al (2021a) Effects of chitosan-collagen dressing on wound healing in vitro and in vivo assays. J Appl Biomater Funct Mater 19:1–10. https://doi.org/10.1177/2280800021989698
Zhang W, Qin W, Li H, Wu AM (2021b) Biosynthesis and transport of nucleotide sugars for plant hemicellulose. Front Plant Sci 12. https://doi.org/10.3389/fpls.2021.723128
Zhao X, Zhou L, Li Q, Zou Q, Du C (2018) Biomimetic mineralization of carboxymethyl chitosan nanofibers with improved osteogenic activity in vitro and in vivo. Carbohydr Polym 195:225–234. https://doi.org/10.1016/j.carbpol.2018.04.090
Zhu L, Zhao L, Qu X, Yang Z (2012) PH-sensitive polymeric vesicles from coassembly of amphiphilic cholate grafted poly(l-lysine) and acid-cleavable polymer-drug conjugate. Langmuir 28(33):11988–11996. https://doi.org/10.1021/la3015767
Zhuo S, Zhang F, Yu J, Zhang X, Yang G, Liu X (2020) pH-sensitive biomaterials for drug delivery. Molecules 25(23):1–20. https://doi.org/10.3390/molecules25235649
Acknowledgements
H.S.N expressed gratitude to the CSIR-UGC (Council of Scientific and Industrial Research-University Grants Commission) for providing a junior researcher scholarship (JUNE18-359427) that supported their Ph.D. work.
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H.S.N the first author of the book chapter and was responsible for writing the manuscript. P.M.S, the second author, contributed to the book chapter by drawing tables and obtaining permission to use photographs from respected journals. R.W.R reviewed the manuscript, provided valuable feedback, and made necessary revisions to enhance the overall quality and coherence of the content.
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Naik, H.S., Sah, P.M., Raut, R.W. (2023). Biomaterials in Drug Delivery Systems. In: Santra, T.S., Shinde, A.U.S. (eds) Advanced Drug Delivery. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 26. Springer, Singapore. https://doi.org/10.1007/978-981-99-6564-9_12
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