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Conventional Approaches Toward the Production of Bioactive Compounds from Medicinal Plants

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Genetic Manipulation of Secondary Metabolites in Medicinal Plant

Part of the book series: Interdisciplinary Biotechnological Advances ((IBA))

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Abstract

Bioactive compounds in plants are basically secondary plant metabolites. These bioactive compounds are formed within the medicinal plant via the primary metabolic pathway and are not essential for its normal growth and development. Bioactive compounds found in medicinal plants have a lot of phytoceutical properties; these bioactive compounds protect plants from several foreign particles and are utilized for cell signaling. Apart from this, these bioactive constituents are used to prepare valuable products such as medicines, perfumes, flavorings, pesticides, coloring agents, etc. Therefore, medicinal plants are more popular among the people because of their applicability to the treatment of common as well as chronic diseases. Molecular biology as well as biotechnology shows a very significant role in the field of pharmaceutical compound. Nowadays, there are various important biotechnological as well as molecular biology tools available like micropropagation, embryo culture, anther culture, and fermentation based tools that have enabled in vitro production of bioactive compounds. Micropropagation is widely exploited to enhance the production of bioactive compound, but it is costly. So, the bioreactor based production of pharmaceutical constituents in medicinal plants through the culture of plant cells is not feasible. Elicitation will also act as a tool for the enhancement of pharmaceutical compounds in medicinal and aromatic plants. This paper provides a detailed description of the various conventional modes of producing bioactive compounds for better understanding and summarizes their potential to help evaluate their suitability and economic feasibility.

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References

  • Arakawa O (1988) Photo-regulation of anthocyanin synthesis in apple fruit under UV-B and red light. Plant Cell Physiol 29(8):1385–1389

    CAS  Google Scholar 

  • Baydar H (2005) Tıbbi, Aromatik ve Keyf Bitkileri Bilimi ve Teknolojisi, Süleyman Demirel Ãœniversitesi Yayınları No: 51 (ISBN 975-7929-79-4) 221 ss, Isparta (in Turkish)

    Google Scholar 

  • Behera N, Mahalakshmi GS (2019) A cloud based knowledge discovery framework, for medicinal plants from PubMed literature. Inform Med Unlocked 16:100–226

    Google Scholar 

  • Bérdy J (2005) Bioactive microbial metabolites. J Antibiot 58(1):1–26

    Article  Google Scholar 

  • Berkov S (2001) Size and alkaloid content of seeds in induced autotetraploids of Datura innoxia, Datura stramonium and Hyoscyamus Niger. Pharm Biol 39(5):329–331

    Article  CAS  Google Scholar 

  • Berkov S, Philipov S (2002) Alkaloid production in diploid and autotetraploid plants of Datura stramonium. Pharm Biol 40:617–621

    Article  CAS  Google Scholar 

  • Bertea CM, Azzolin CMM, Bossi S, Doglia G, Maffei ME (2005) Identification of an EcoRl restriction site for a rapid and precise determination of—asarone-free Acorus calamus cytotypes. Phytochemistry 66:507–514

    Article  CAS  Google Scholar 

  • Budiarto R, Poerwanto R, Santosa E, Efendi D (2019) A review of root pruning to regulate citrus growth. J Trop Crop Sci 6(1):1–7

    Article  Google Scholar 

  • Campos RA, Junior SS, Gonçalves GG, Neves LG, de Gusmão SA, Vianello F, Lima GP (2019) Changes in bioactive compounds in spiny coriander leaves in response to inflorescence pruning at different growth stages. Sci Hortic 245:250–257

    Article  CAS  Google Scholar 

  • Cao M, Gan Q, Xu Y, Lu JK, Zhong L, Wang M, Liu S, Wang L (2022) Pruning improves seedling development and bioactive secondary metabolite accumulation in the leaves of Ginkgo biloba. Trees 36(3):953–966

    Article  CAS  Google Scholar 

  • Caris-Veyrat C, Amiot MJ, Tyssandier V, Graselly D, Buret M, Mikolajczak M (2004) Influence of organic versus conventional agricultural practice on the antioxidant microconstituent content of tomatoes and derived purees; consequences on antioxidant plasma status in humans. J Agric Food Chem 52:6503–6509

    Article  CAS  Google Scholar 

  • Caruso I, Lepore L, De Tommasi N, Dal Piaz F, Frusciante L, Aversano R, Carputo D (2011) Secondary metabolite profile in induced tetraploids of wild Solanum commersonii dun. Chem Biodivers 8:2226–2237

    Article  CAS  Google Scholar 

  • Chakraborty P (2018) Herbal genomics as tools for dissecting new metabolic pathways of unexplored medicinal plants and drug discovery. Biochimie Open 6:9–16

    Article  Google Scholar 

  • Chang X, Alderson PG, Wright CJ (2009) Enhanced UV-B radiation alters basil (Ocimum basilicum L.) growth and stimulates the synthesis of volatile oils. J Hortic For 1:027–031

    Google Scholar 

  • Clark JR, Matheny N (2010) The research foundation to tree pruning: a review of the literature. Arboricult Urban For 36:110–120

    Article  Google Scholar 

  • Dietrich H, Rechner A, Patz CD (2004) Bioactive compounds in fruit and juice. Fruit Process 1:50–55

    Google Scholar 

  • Dixit V, Chaudhary BR (2014) Colchicine-induced tetraploidy in garlic (Allium sativum L.) and its effect on allicin concentration. J Hortic Sci Biotech 89:585–591

    Article  Google Scholar 

  • Du ZY, Xing SJ, Ma BY, Liu FC, Ma HL, Wang QH (2012) Effects of root pruning on the growth and rhizosphere soil characteristics of short-rotation closed-canopy poplar. For Syst 21(2):236–246

    Google Scholar 

  • Dumas Y, Dadomo M, Lucca G, Grolier P, Di Lucca G (2003) Effect of environmental factors and agricultural techniques on antioxidant content of tomatoes. J Sci Food Agric 83:369–382

    Article  CAS  Google Scholar 

  • Fathima TI, Udayan PS, Somashekar RK, Ved DK (2018) Prioritization of medicinal plants in sholas of Western Ghats: a case study. J Med Plant Res 6(1):7–10

    Google Scholar 

  • Flieβbach A, Oberholzer HR, Gunst L, Mader P (2007) Soil organic matter and biological soil quality indicators after 21 years of organic and conventional farming. Agric Ecosyst Environ 118:273–284

    Article  Google Scholar 

  • Frías-Moreno MN, Parra-Quezada RA, González-Aguilar G, Ruíz-Canizales J, Molina-Corral FJ, Sepulveda DR, Salas-Salazar N, Olivas GI (2021) Quality, bioactive compounds, antioxidant capacity, and enzymes of raspberries at different maturity stages, effects of organic vs conventional fertilization. Foods 10(5):953

    Article  Google Scholar 

  • Garshasbi M, Rafieiolhossaini M, Fallah S, Jafari AA, Rezazadeh S (2021) Effects of intercropping and fertilizer types on DM yield and medicinal metabolites of chicory and fenugreek. J Med Plant Byproduct 12:57–68

    Google Scholar 

  • Geilfus CM (2019) Controlled environment horticulture. Colorado State University, Fort Collins, CO

    Book  Google Scholar 

  • Germ M, Stibilj V, Kreft S, GaberÅ¡cik A, Kreft I (2010) Flavonoid, tannin and hypericin concentrations in the leaves of St John’s wort (Hypericum perforatum L) are affected by UV-B radiation levels. Food Chem 122:471–474. https://doi.org/10.1016/j.foodchem.2010.03.008

    Article  CAS  Google Scholar 

  • Gholami H, Saharkhiz MJ, Fard FR, Ghani A, Nadaf F (2018) Humic acid and vermicompost increased bioactive components, antioxidant activity and herb yield of chicory (Cichorium intybus L.). Biocatal Agric Biotechnol 14:286–292

    Article  Google Scholar 

  • Ghotbi RE, Rezanejad F, Zolala J, Dehghan E (2013) The effects of chromosome-doubling on selected morphological and phytochemical characteristics of Cichorium intybus L. J Hortic Sci Biotech 88:701–709

    Article  Google Scholar 

  • Hakkinen SH, Torronen AR (2000) Content of flavonoids and selected phenolic acid in strawberries and vaccinium species: influence of cultivar, cultivation site and technique. Food Res Int 33:517–524

    Article  CAS  Google Scholar 

  • Higashio H, Hirokane H, Sato F, Tokuda S, Uragami A (2007) Enhancement of functional compounds in allium vegetables with UV radiation. Acta Hortic 744:357–361

    Article  CAS  Google Scholar 

  • Jain SC, Agrawal M (1987) Effect of chemical mutagens on steroidal sapogenins in Trigonella species. Phytochemistry 26(8):2203–2205

    Article  CAS  Google Scholar 

  • Johnson CB, Kirby J, Naxakis G, Pearson S (1999) Substantial UV-B-mediated induction of essential oils in sweet basil (Ocimum basilicum L.). Phytochemistry 51(4):507–510

    Article  CAS  Google Scholar 

  • Jordan MA, Leslie W (2004) Microtubules as a target for antic cancer drugs. Nat Rev Cancer 4(4):253–265

    Article  CAS  Google Scholar 

  • Jordanov R, Zheljazkov V, Tsevtkov RR (1995) Induced polyploidy in lavender. Int Symp Med Aromat Plants 426:561–572

    Google Scholar 

  • Joshi R, Satyal P, Setzer W (2016) Himalayan aromatic medicinal plants: a review of their ethnopharmacology, volatile phytochemistry, and biological activities. Medicine 3(1):6

    Google Scholar 

  • Karimi A, Majlesi M, Rafieian-Kopaei M (2015) Herbal versus synthetic drugs; beliefs and facts. J Nephropharmacol 4:27–30

    CAS  Google Scholar 

  • Khalkho AS, Sahu PR, Kumari S, Alam S (2015) Studies on ethnomedicinal uses and formulation of herbal drugs from medicinal plants of Ranchi District—a survey. Am J Ethnomed 2:284–296

    Google Scholar 

  • Kolakar SS, Nadukeri S, Jakkeral SA, Hanumanthappa M, Gangaprasad S (2018) Role of mutation breeding in improvement of medicinal and aromatic crops: review. J Pharmacog Phytochem:425–429

    Google Scholar 

  • Kumar A, Bhamini K, Perween S, Singh RS, Prasad K, Singh DN (2018a) Elicitation as a tool to enhance the profiles of high value secondary metabolite production in medicinal plants. Multilogic in science, ISSN 2277-7601

    Google Scholar 

  • Kumar A, Singh RS, Kumar U, Kumari R, Thakur D, Pal AK, Singh PK (2018b) Expression of MYB transcription factor genes in response to methyl Jasmonate, salicylic acid and sodium Nitropruside in Selaginella bryopteris (L.) baker. Int J Agric Environ Biotechnol 11(2):243–251

    Google Scholar 

  • Kumari R, Agrawal SB (2010) Comparative analysis of essential oil composition and oil containing glands in Ocimum sanctum L. (holy basil) under ambient and supplemental level of UV-B through gas chromatography–mass spectrometry (GC-MS) and scanning electron microscopy (SEM). Acta Physiol Plant 33:1093–1110. https://doi.org/10.1007/s11738-010-0637-0

    Article  CAS  Google Scholar 

  • Kumari R, Agrawal SB, Sarkar A (2009a) Evaluation of changes in oil cells and composition of essential oil in lemongrass ( Cymbopogon citratus (DC) Stapf) due to supplemental ultraviolet–B irradiation. Curr Sci 97:1137–1142

    CAS  Google Scholar 

  • Kumari R, Agrawal SB, Singh S, Dubey NK (2009b) Supplemental ultraviolet-B induced changes in essential oil composition and total phenolics of Acorus calamus L (sweet flag). Ecotoxicol Environ Saf 72:2013–2019. https://doi.org/10.1016/j.ecoenv.2009.02.006

    Article  CAS  Google Scholar 

  • Laloo D, Kalita JM, Prasad SK (2021) Molecular docking studies of plant-derived bioactive compounds: a comprehensive in silico standardization approach. In: Evidence based validation of traditional medicines. Springer, Singapore, pp 371–404

    Chapter  Google Scholar 

  • Lam VP, Kim SJ, Lee HJ, Park JS (2019) Root pruning increased bioactive compounds of hydroponically-grown Agastache rugosa in a greenhouse. Hortic Environ Biotechnol 60:647–657

    Article  CAS  Google Scholar 

  • Levin DA (2002) The role of chromosomal change in plant evolution. Syst Bot 29:460. https://doi.org/10.1600/036364404774195656

    Article  Google Scholar 

  • Li G, Lou HX (2018) Strategies to diversify natural products for drug discovery. Med Res Rev 38:1255–1294

    Article  Google Scholar 

  • Lin X, Zhou Y, Zhang J, Lu X, Zhang F, Shen Q, Wu S, Chen Y, Wang T, Tang K (2011) Enhancement of artemisinin content in tetraploid Artemisia annua plants by modulating the expression of genes in artemisinin biosynthetic pathway. Biotechnol Appl Biochem 58:50–57

    Article  CAS  Google Scholar 

  • Lugaresi A, Uberti A, Giacobbo CL, Lovatto M, Girardi GC, Wagner Junior A (2018) Management of pruning and evaluation in blackberry cultivars in relation to productive characteristics and bioactive compounds. An Acad Bras Cienc 90:3879–3885

    Article  CAS  Google Scholar 

  • Machiani AM, Javanmard A, Morshedloo MR, Aghaee A, Maggi F (2021) Funneliformis mosseae inoculation under water deficit stress improves the yield and phytochemical characteristics of thyme in intercropping with soybean. Sci Rep 11(1):152–179

    Google Scholar 

  • Medical News Today (2007). http://www.medicalnewstoday.com/articles/86972.php

  • Mehta A, Hasija Y (2018) Bioinformatics approaches for genomics and post genomics applications of anticancer plants. In: Anticancer plants: mechanisms and molecular interactions. Springer, Singapore, pp 283–317

    Chapter  Google Scholar 

  • Mehta N, Jain A, Rajkumar M (2020) Impact of pruning of Diospyros melanoxylon Roxb. (Tendu) bushes on yield and quality of leaves in Maharashtra. J Pharmacogn Phytochem 9:1360–1365

    Article  Google Scholar 

  • Mishra BK, Pathak S, Sharma A, Trivedi PK, Shukla S (2010) Modulated gene expression in newly synthesized autotetraploid of Papaver somniferum L. S Afr J Bot 76(3):447–452

    Article  CAS  Google Scholar 

  • Mitchell AE, Hong YJ, Koh E, Barrett DM, Bryant DE (2007) Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes. J Agric Food Chem 55:6154–6159

    Article  CAS  Google Scholar 

  • Mitran T, Kumar P, Bandyopadhyay PK, Basak N (2017) Effects of organic amendments on soil physical attributes and aggregate-associated phosphorus under long-term rice-wheat cropping. Pedosphere 28(5):823–832

    Article  Google Scholar 

  • Moetamedipoor SA, Jowkar A, Saharkhiz MJ, Hassani HS (2022) Hexaploidy induction improves morphological, physiological and phytochemical characteristics of mojito mint (Mentha × villosa). Sci Hortic 295:110810

    Article  CAS  Google Scholar 

  • Mohd HI, Hawa ZEJ, Eshan K, Ali G (2013) Impact of organic and inorganic fertilizers application on the phytochemical and antioxidant activity of Kacip Fatimah (Labisia pumila Benth). Molecules 18(9):10973–10988

    Article  Google Scholar 

  • Mussarat S, Abdel-Salam NM, Tariq A, Wazir SM, Ullah R, Adnan M (2014) Use of ethnomedicinal plants by the people living around Indus River. J Evid Based Complement Alternat Med 2014:1–14

    Article  Google Scholar 

  • Nichenametla SN, Taruscio TG, Barney DL, Exon JH (2006) A review of the effects and mechanism of polyphenolics in cancer. Crit Rev Food Sci Nutr 46:161–183

    Article  CAS  Google Scholar 

  • O’Donovan B, Rodgers RM, Cox AR, Krska J (2019) ‘You feel like you haven’t got any control’: a qualitative study of side effects from medicines. J Patient Saf Risk Manag 24:13–24

    Article  Google Scholar 

  • Okunade A, Hufford C, Clark A, Lentz D (1997) Antimicrobial properties of the constituents of Piper aduncum. Phytother Res 11:142–144

    Article  Google Scholar 

  • Olsson ME, Gustavsson KE, Andersson S, Nilsson A, Duan RD (2004) Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem 52:7264–7271

    Article  CAS  Google Scholar 

  • Ottesen GH (2010) Increased levels of bioactive compounds in organically grown food plants. Possible health effects. In: Bioactive compounds in plants—benefits and risks for man and animals, pp 236–252

    Google Scholar 

  • Pacheco AL, Pagliarini MF, De Freitas GB, Santos RH, Serrão JE, Zanuncio JC (2017) Mineral composition of pulp and production of the yellow passion fruit with organic and conventional fertilizers. Food Chem 217:425–430

    Article  CAS  Google Scholar 

  • Padilla A, Hogan R, Kaiser RB (2007) The toxic triangle: destructive leaders, susceptible followers, and conducive environments. Leadersh Q 18:176–194

    Article  Google Scholar 

  • Pank F (2006) Adaptation of medicinal and aromatic plants to contemporary quality and technological demands by breeding: aims, methods and trends. Rev Bras Plant Med 8:39–42

    Google Scholar 

  • Peng Z, Zhang Y, Yan B, Zhan Z, Chi X, Xu Y, Guo X, Cui X, Wang T, Wang S, Kang C (2021) Diverse intercropping patterns enhance the productivity and volatile oil yield of Atractylodes lancea (Thunb.) DC. Front Plant Sci 12:663–730

    Article  Google Scholar 

  • Perez DP, Lim W, Seiler JP, Yi G, Peiris M, Shortridge KF, Webster RG (2003) Role of quail in the interspecies transmission of h9 influenza a viruses: molecular changes on HA that correspond to adaptation from ducks to chickens. J Virol 77(5):3148–3156

    Article  CAS  Google Scholar 

  • Ponder A, Hallmann E (2019) The effects of organic and conventional farm management and harvest time on the polyphenol content in different raspberry cultivars. Food Chem 301:125295

    Article  CAS  Google Scholar 

  • Rauha JP, Remes S, Heinonen M, Hopia A, Kkahkonen M, Kuyala T, Pihlaya K, Vuorela H, Vuorela P (2000) Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Int J Food Microbiol 56:3–12

    Article  CAS  Google Scholar 

  • Rembialkowska E (2007) Quality of plant products from organic agriculture (review). J Sci Food Agric 87:2757–2768

    Article  CAS  Google Scholar 

  • Reyburn H, Mtove G, Hendriksen I, Von SL (2009) Oral qui-nine for the treatment of uncomplicated malaria. Br Med J (Clin Res Ed) 339:2066. https://doi.org/10.1136/bmj.b2066

    Article  Google Scholar 

  • Rezaei-Chiyaneh E, Mahdavikia H, Battaglia ML, Thomason WE, Caruso G (2021) Intercropping and fertilizer type impact seed productivity and secondary metabolites of dragon's head and fenugreek. Sci Hortic 287:110277

    Article  CAS  Google Scholar 

  • Rodney C, Toni M, Kutchan N, Lewis G (2000) Biochemistry and molecular biology of plants. In: Buchanan B, Gruissem W, Jones R (eds) Natural products, vol 10. Wiley, Rockville, MD, pp 1253–1348

    Google Scholar 

  • Salas CE, Badillo-Corona JA, Ramírez-Sotelo G, Oliver-Salvador C (2015) Biologically active and antimicrobial peptides from plants. Biomed Res Int 2015:102–129

    Article  Google Scholar 

  • Salehi A, Fallah S, Zitterl-Eglseer K, Kaul HP, Abbasi Surki A, Mehdi B (2019) Effect of organic fertilizers on antioxidant activity and bioactive compounds of fenugreek seeds in intercropped systems with buckwheat. Agronomy 9(7):367

    Article  CAS  Google Scholar 

  • Santos ARS, De Campos ROP, Miguel OG, Filho VC, Siani AC, Yunes RA, Calixto JB (2000) Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae). J Ethnopharmacol 72:229–238

    Article  CAS  Google Scholar 

  • Sardzhveladze GP, Kharebava LG (1990) Studies on the raw material and made tea of the polyploid no. 2582-VICh II of the cultivar Kolkhida. Subtroicheskie Kultury 4:52–57

    Google Scholar 

  • Schippmann U, Leaman D, Cunningham A (2006) A comparison of cultivation and wild collection of medicinal and aromatic plants under sustainability aspects. Frontis:75–95

    Google Scholar 

  • Selmar D, Kleinwachter M (2013) Influencing the product quality by deliberately applying drought stress during the cultivation of medicinal plants. Ind Crop Prod 42:558–566

    Article  CAS  Google Scholar 

  • Singh B, Singh JP, Kaur A, Singh N (2017) Phenolic composition and antioxidant potential of grain legume seeds: a review. Food Res Int 101:1–16

    Article  CAS  Google Scholar 

  • Singh RS, Kesari R, Kumar U, Jha VK, Kumar A, Kumar T, Pal AK, Singh PK (2018) Candidate genes of flavonoid biosynthesis in Selaginella bryopteris (L.) baker identified by RNA-Seq. Funct Integr Genomics 18:505. https://doi.org/10.1007/s10142-018-0603-2

    Article  CAS  Google Scholar 

  • Stephen O, David AA, Abdullahi AB, Oludare OA (2014) Effect of NPK and poultry manure on growth, yield, and proximate composition of three amaranths. J Bot 6:828750

    Google Scholar 

  • Swamy MK (ed) (2020) Plant-derived bioactives: production, properties and therapeutic applications. Springer Nature, Berlin

    Google Scholar 

  • Talebi SF, Saharkhiz MJ, Kermani MJ, Sharafi Y, Fard RF (2017) Effect of different antimitotic agents on polyploid induction of anise hyssop (Agastache foeniculum L.). Caryologia 70:184–193

    Article  Google Scholar 

  • Tewari D, Rawat P, Singh PK (2019) Adverse drug reactions of anticancer drugs derived from natural sources. Food Chem Toxicol 123:522–535

    Article  CAS  Google Scholar 

  • Tsuda H, Ishitani Y, Takemura Y, Suzuki Y, Kato T (1997) 6-acetyl-8-hydroxy-2, 2-dimethylchromene, an antioxidant in sunflower seeds; its isolation and synthesis and antioxidant activity of its derivatives. Heterocycles 44:139–142

    Article  CAS  Google Scholar 

  • Tuan P, Park W, Xu H, Park N, Park S (2012) Accumulation of tilianin and rosmarinic acid and expression of phenylpropanoid biosynthetic genes in Agastache rugosa. J Agric Food Chem 60:5945–5951. https://doi.org/10.1021/jf300.833m

    Article  CAS  Google Scholar 

  • Uwineza PA, WaÅ›kiewicz A (2020) Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials. Molecules 25(17):3847

    Article  CAS  Google Scholar 

  • Verpoorte R, Contin A, Memelink J (2002) Biotechnology for the production of plant secondary metabolites. Phytochem Rev 1:13–25

    Article  CAS  Google Scholar 

  • Wiebel F, Bickel R, Leuthold S, Alfoldi T (2000) Are organically grown apples tastier and healthier? A comparative filed study using conventional and alternative methods to measure fruit quality. Acta Hortic 57:417–426

    Article  Google Scholar 

  • World Health Organization (WHO) (2019) Neglected tropical diseases. https://web.archive.org/web/20140227152033/; http://www.who.int/neglecteddiseases/en/

  • Xu CG, Tang TX, Chen R, Liang CH, Liu XY, Wu CL, Yang YS, Yang DP, Wu H (2014) A comparative study of bioactive secondary metabolite production in diploid and tetraploid Echinacea purpurea (L.) Moench. Plant Cell Tiss Org Cult 116:323–332

    Article  CAS  Google Scholar 

  • Yang B, Hu L, Shen H, Sun X, Zhang P (2018) Effect of mounding and top-pruning on survival and growth of manchurian ash seedlings planted under the secondary forest of the species. Scientia Silvae Sinicae 51:104–113

    CAS  Google Scholar 

  • Zahedi AA, Hosseini B, Fattahi M, Dehghan E, Parastar H, Madani H (2014) Overproduction of valuable methoxylated flavones in induced tetraploid plants of Dracocephalum kotschyi Boiss. Bot Stud 55:1–10

    Article  Google Scholar 

  • Zeinab AS, Farouk KE, Alaa AG, Mohamed FZ (2013) Antioxidant activities of phenolics, flavonoids and vitamin C in two cultivars of fennel (Foeniculum vulgare) in responses to organic and bio-organic fertilizers. J Saudi Soc Agric Sci 14:91–99

    Google Scholar 

  • Zhang L, Koc AB, Wang XN, Jiang YX (2018) A review of pruning fruit trees. IOP Conf Ser Earth Environ Sci 153:062029

    Article  Google Scholar 

  • Zielinska S, Matkowski A (2014) Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae). Phytochem Rev 13:391–416. https://doi.org/10.1007/s1110-1-014-9349-1

    Article  CAS  Google Scholar 

  • Zu YG, Pang HH, Yu JH, Li DW, Wei XX, Gao YX, Tong L (2010) Responses in the morphology, physiology and biochemistry of Taxus chinensis var mairei grown under supplementary UV-B radiation. J Photochem Photobiol B Biol 98:152–158. https://doi.org/10.1016/j.jphotobiol.200

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Genetics and Plant Breeding, Agriculture College Garhwa, BAU, Ranchi, Jharkhand, India

    Anjani Kumar

  2. Department of Horticulture (Fruit), Nalanda College of Horticulture, Noorsarai, Nalanda, Bihar, India

    Kanchan Bhamini

  3. BAU, Sabour, Bhagalpur, Bihar, India

    Kanchan Bhamini

  4. ZRS (BAU Ranchi), Chianki, Palamau, Jharkhand, India

    D. N. Singh

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  1. Anjani Kumar
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  1. Plant Breeding and Genetics, Bihar Agricultural University, Sabour, Bihar, India

    Ravi Singh

  2. Department of Biotechnology, Central University of South Bihar, Gaya, Bihar, India

    Nitish Kumar

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Kumar, A., Bhamini, K., Singh, D.N. (2023). Conventional Approaches Toward the Production of Bioactive Compounds from Medicinal Plants. In: Singh, R., Kumar, N. (eds) Genetic Manipulation of Secondary Metabolites in Medicinal Plant. Interdisciplinary Biotechnological Advances. Springer, Singapore. https://doi.org/10.1007/978-981-99-4939-7_1

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