Abstract
Cancer represents one of the most known life-threatening health disorders, which has inflicted a heavy burden on individual lives owing to high incidence, disability, and fatality. Notwithstanding advances in conventional chemotherapeutic methods, limitations like treatment-associated adverse effects and drug resistance accentuate the consequential importance of propounding new therapeutic scenarios. In this regard, medicinal plants and their bioactive ingredients have been used comprehensively to treat human disorders long ago and, nowadays, have grabbed special attention for their potential in cancer treatment by targeting different mechanisms that play a crucial role in its occurrence and regression. However, these agents are majorly hydrophobic in nature, and their application as therapeutic dosage forms faces some bottlenecks, namely, weak water solubility, low oral bioavailability, and high doses needed. Hereupon, novel strategies, particularly nano-based formulation and drug delivery methods, are exploited to surpass the abovementioned drawbacks of these health valuable natural products via mitigated side effects and increased effectiveness, stability, and pharmacokinetic issues. In the present study, we aim to highlight the potential of nanotechnology in the formulation and delivery of natural products, their advantages, and challenges for cancer management.
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References
Abouaitah, K. & Lojkowski, W. 2021. Delivery of natural agents by means of mesoporous silica nanospheres as a promising anticancer strategy Pharmaceutics. 13, 143. https://doi.org/10.3390/pharmaceutics13020143
Afrose SS, Junaid M, Akter Y, Tania M, Zheng M, Khan MA (2020) Targeting kinases with thymoquinone: a molecular approach to cancer therapeutics. Drug Discov Today 25:2294–2306. https://doi.org/10.1016/j.drudis.2020.07.019
Ailioaie LM, Ailioaie C, Litscher G (2021) Latest innovations and nanotechnologies with curcumin as a nature-inspired photosensitizer applied in the photodynamic therapy of cancer. Pharmaceutics 13. https://doi.org/10.3390/pharmaceutics13101562
Anari E, Akbarzadeh A, Zarghami N (2016) Chrysin-loaded Plga-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. Artif Cells Nanomed Biotechnol 44:1410–1416. https://doi.org/10.3109/21691401.2015.1029633
Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 20:200–216. https://doi.org/10.1038/s41573-020-00114-z
Bensa V, Calarco E, Giusto E, Perri P, Corrias MV, Ponzoni M, Brignole C, Pastorino F (2021) Retinoids delivery systems in cancer: liposomal Fenretinide for Neuroectodermal-derived tumors. Pharmaceuticals (Basel, Switzerland) 14:854. https://doi.org/10.3390/ph14090854
Bhia M, Motallebi M, Abadi B, Zarepour A, Pereira-Silva M, Saremnejad F, Santos AC, Zarrabi A, Melero A, Jafari SM, Shakibaei M (2021) Naringenin nano-delivery systems and their therapeutic applications. Pharmaceutics 13. https://doi.org/10.3390/pharmaceutics13020291
Chaudhary Z, Subramaniam S, Khan GM, Abeer MM, Qu Z, Janjua T, Kumeria T, Batra J, Popat A (2019) Encapsulation and controlled release of resveratrol within functionalized mesoporous silica nanoparticles for prostate cancer therapy. 7. https://doi.org/10.3389/fbioe.2019.00225
Chen Y, Pan L, Jiang M, Li D, Jin L (2016) Nanostructured lipid carriers enhance the bioavailability and brain cancer inhibitory efficacy of curcumin both in vitro and in vivo. Drug Deliv 23:1383–1392. https://doi.org/10.3109/10717544.2015.1049719
D’angelo NA, Noronha MA, Kurnik IS, Câmara MCC, Vieira JM, Abrunhosa L, Martins JT, Alves TFR, Tundisi LL, Ataide JA, Costa JSR, Jozala AF, Nascimento LO, Mazzola PG, Chaud MV, Vicente AA, Lopes AM (2021) Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview. Int J Pharm 604:120534. https://doi.org/10.1016/j.ijpharm.2021.120534
Dhupal M, Chowdhury D (2020) Phytochemical-based nanomedicine for advanced cancer Theranostics: perspectives on clinical trials to clinical use. Int J Nanomedicine 15:9125–9157. https://doi.org/10.2147/Ijn.S259628
Falzone L, Salomone S, Libra M (2018) Evolution of cancer pharmacological treatments at the turn of the third millennium. Front Pharmacol 9:1300. https://doi.org/10.3389/fphar.2018.01300
Gao Y, Li Z, Xie X, Wang C, You J, Mo F, Jin B, Chen J, Shao J, Chen H, Jia L (2015) Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: synthesis and biological evaluation. Eur J Pharm Sci 70:55–63. https://doi.org/10.1016/j.ejps.2015.01.007
Garcia-Oliveira P, Otero P, Pereira AG, Chamorro F, Carpena M, Echave J, Fraga-Corral M, Simal-Gandara J, Prieto MA (2021) Status and challenges of plant-anticancer compounds in cancer treatment. Pharmaceuticals (Basel) 14. https://doi.org/10.3390/ph14020157
Geetha R, Ashokkumar T, Tamilselvan S, Govindaraju K, Sadiq M, Singaravelu G (2013) Green synthesis of gold nanoparticles and their anticancer activity. Cancer Nanotechnol 4:91–98. https://doi.org/10.1007/s12645-013-0040-9
Gunasekaran T, Haile T, Nigusse T, Dhanaraju MD (2014) Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pac J Trop Biomed 4, S1–S7. https://doi.org/10.12980/Apjtb.4.2014C980
Gupta S, Tejavath K (2022) Nano phytoceuticals: a step forward in tracking down paths for therapy against pancreatic ductal adenocarcinoma. J Clust Sci. https://doi.org/10.1007/s10876-021-02213-2
Javed Iqbal M, Quispe C, Javed Z, Sadia H, Qadri QR, Raza S, Salehi B, Cruz-Martins N, Abdulwanis Mohamed Z, Sani Jaafaru M, Abdull Razis AF, Sharifi-Rad J (2021) Nanotechnology-based strategies for berberine delivery system in cancer treatment: pulling strings to keep berberine in power. Front Mol Biosci:7. https://doi.org/10.3389/fmolb.2020.624494
Kaplan A (2022) The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applications. Beni-Suef Univ J Basic Appl Sci 11. https://doi.org/10.1186/s43088-022-00198-z
Kaps A, Gwiazdoń P, Chodurek E (2021) Nanoformulations for delivery of pentacyclic triterpenoids in anticancer therapies. 26:1764. https://doi.org/10.3390/molecules26061764
Kashyap D, Tuli HS, Yerer MB, Sharma A, Sak K, Srivastava S, Pandey A, Garg VK, Sethi G, Bishayee A (2021) Natural product-based nanoformulations for cancer therapy: opportunities and challenges. Semin Cancer Biol 69:5–23. https://doi.org/10.1016/j.semcancer.2019.08.014
Kazi M, Nasr FA, Noman O, Alharbi A, Alqahtani MS, Alanazi FK (2020) Development, characterization optimization, and assessment of curcumin-loaded bioactive self-nanoemulsifying formulations and their inhibitory effects on human breast cancer MCF-7 cells. Pharmaceutics 12. https://doi.org/10.3390/pharmaceutics12111107
Kim B, Park JE, Im E, Cho Y, Lee J, Lee HJ, Sim DY, Park WY, Shim BS, Kim SH (2021) Recent advances in nanotechnology with Nano-phytochemicals: molecular mechanisms and clinical implications in cancer progression. Int J Mol Sci 22. https://doi.org/10.3390/ijms22073571
Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, Harvey JD, Henrikson HJ, Lu D, Pennini A, Xu R, Ababneh E, Abbasi-Kangevari M, Abbastabar H, Abd-Elsalam SM, Abdoli A, Abedi A, Abidi H, Abolhassani H, Adedeji IA, Adnani QES, Advani SM, Afzal MS, Aghaali M, Ahinkorah BO, Ahmad S, Ahmad T, Ahmadi A, Ahmadi S, Ahmed Rashid T, Ahmed Salih Y, Akalu GT, Aklilu A, Akram T, Akunna CJ, Al Hamad H, Alahdab F, Al-Aly Z, Ali S, Alimohamadi Y, Alipour V, Aljunid SM, Alkhayyat M, Almasi-Hashiani A, Almasri NA, Al-Maweri SAA, Almustanyir S, Alonso N, Alvis-Guzman N, Amu H, Anbesu EW, Ancuceanu R, Ansari F, Ansari-Moghaddam A, Antwi MH, Anvari D, Anyasodor AE, Aqeel M, Arabloo J, Arab-Zozani M, Aremu O, Ariffin H, Aripov T, Arshad M, Artaman A, Arulappan J, Asemi Z, Asghari Jafarabadi M, Ashraf T, Atorkey P, Aujayeb A, Ausloos M, Awedew AF, Ayala Quintanilla BP, Ayenew T, Azab MA, Azadnajafabad S, Azari Jafari A, Azarian G, Azzam AY, Badiye AD, Bahadory S, Baig AA, Baker JL, Balakrishnan S, Banach M, Bärnighausen TW, Barone-Adesi F, Barra F, Barrow A, Behzadifar M, Belgaumi UI, Bezabhe WMM, Bezabih YM, Bhagat DS, Bhagavathula AS, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhattacharyya K, Bhojaraja VS et al (2022) Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the global burden of disease study 2019. JAMA Oncol 8:420–444. https://doi.org/10.1001/jamaoncol.2021.6987
Kumar P, Yadav N, Chaudhary B, Jain V, Balaramnavar VM, Alharbi KS, Alenezi SK, Al-Malki WH, Ghoneim MM, Alshehri S, Imam SS, Gupta MM (2022) Promises of phytochemical based nano drug delivery systems in the management of cancer. Chem Biol Interact 351:109745. https://doi.org/10.1016/j.cbi.2021.109745
Li C, Zhao Y, Yang D, Yu Y, Guo H, Zhao Z, Zhang B, Yin X (2015) Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Biochem Cell Biol 93:16–27. https://doi.org/10.1139/bcb-2014-0067
Liang Y, Liu ZY, Wang PY, Li YJ, Wang RR, Xie SY (2021) Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant. J Control Release 336:396–409. https://doi.org/10.1016/j.jconrel.2021.06.034
Manjili HK, Malvandi H, Mousavi MS, Attari E, Danafar H (2018) In vitro and in vivo delivery of artemisinin loaded PCL-PEG-PCL micelles and its pharmacokinetic study. Artif Cells Nanomed Biotechnol 46:926–936. https://doi.org/10.1080/21691401.2017.1347880
Maya S, Sabitha M, Nair SV, Jayakumar R (2012) Phytomedicine-loaded polymeric nanomedicines: potential cancer therapeutics. https://doi.org/10.1007/12_2012_195
Meylina L, Muchtaridi M, Joni IM, Mohammed AFA, Wathoni N (2021) Nanoformulations of α-Mangostin for cancer drug delivery system. 13:1993. https://doi.org/10.3390/pharmaceutics13121993
Mittal S, Ashhar MU, Ahuja A, Ali J, Baboota S (2021) Role of natural bioactives and their Nanocarriers for overcoming oxidative stress induced cancer. Curr Med Chem 28:7477–7512. https://doi.org/10.2174/0929867328666210628141550
Mohtashami L, Ghows N, Tayarani-Najaran Z, Iranshahi M (2019) Galbanic acid-coated Fe3O4 magnetic nanoparticles with enhanced cytotoxicity to prostate cancer cells. Planta Med 85:169–178. https://doi.org/10.1055/a-0721-1886
Moshawih S, Mydin RBÂ SMN, Kalakotla S, Jarrar Q (2019) Potential application of resveratrol in nanocarriers against cancer: overview and future trends. J Drug Deliv Sci Technol 53:101187. https://doi.org/10.1016/j.jddst.2019.101187
Orlandella FM, Mirabelli P, De Stefano AE, Iervolino PLC, Luciano N, D’angelo S, Salvatore G (2022) Effects of Annurca flesh apple polyphenols in human thyroid cancer cell lines. Oxidative Med Cell Longev 2022:6268755. https://doi.org/10.1155/2022/6268755
Pradhan D, Biswasroy P, Sahu A, Sahu DK, Ghosh G, Rath G (2021) Recent advances in herbal nanomedicines for cancer treatment. Curr Mol Pharmacol 14:292–305. https://doi.org/10.2174/1874467213666200525010624
Radhakrishnan R, Kulhari H, Pooja D, Gudem S, Bhargava S, Shukla R, Sistla R (2016) Encapsulation of biophenolic phytochemical EGCG within lipid nanoparticles enhances its stability and cytotoxicity against cancer. Chem Phys Lipids 198:51–60. https://doi.org/10.1016/j.chemphyslip.2016.05.006
Ravichandiran V, Masilamani K, Senthilnathan B, Maheshwaran A, Wong TW, Roy P (2017) Quercetin-decorated curcumin liposome design for cancer therapy: in-vitro and in-vivo studies. Curr Drug Deliv 14:1053–1059. https://doi.org/10.2174/1567201813666160829100453
Saha S, D’souza D, Londhe VY (2021) Exploring the concepts of various nano-formulations loaded with herbal drugs moieties against breast cancer using prisma analysis:66. https://doi.org/10.1016/j.jddst.2021.102865
Sahu T, Ratre YK, Chauhan S, Bhaskar LVKS, Nair MP, Verma HK (2021) Nanotechnology based drug delivery system: current strategies and emerging therapeutic potential for medical science. J Drug Deliv Sci Technol 63:102487. https://doi.org/10.1016/j.jddst.2021.102487
Salama L, Pastor ER, Stone T, Mousa SA (2020) Emerging Nanopharmaceuticals and Nanonutraceuticals in cancer management. Biomedicine 8. https://doi.org/10.3390/biomedicines8090347
Senga SS, Grose RP (2021) Hallmarks of cancer-the new testament. Open Biol 11:200358. https://doi.org/10.1098/rsob.200358
Tyagi N, Song YH, De R (2019) Recent progress on biocompatible nanocarrier-based genistein delivery systems in cancer therapy. J Drug Target 27:394–407. https://doi.org/10.1080/1061186X.2018.1514040
Wang J, Li Q, Chen Z, Qi X, Wu X, Di G, Fan J, Guo C (2021a) Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system. Toxicol Appl Pharmacol 419:115511. https://doi.org/10.1016/j.taap.2021.115511
Wang L, Yin Q, Liu C, Tang Y, Sun C, Zhuang J (2021b) Nanoformulations of ursolic acid: a modern natural anticancer molecule:12. https://doi.org/10.3389/fphar.2021.706121
Wang LY, Yeh SL, Hsu ST, Chen CH, Chen CC, Chuang CH (2022) The anti-proliferative and apoptotic effects of Rutaecarpine on human esophageal squamous cell carcinoma cell line CE81T/VGH in vitro and in vivo. Int J Mol Sci 23. https://doi.org/10.3390/ijms23052843
Yadav N, Parveen S, Banerjee M (2020) Potential of nano-phytochemicals in cervical cancer therapy. Clin Chim Acta 505:60–72. https://doi.org/10.1016/j.cca.2020.01.035
Yap KM, Sekar M, Fuloria S, Wu YS, Gan SH, Mat Rani NNI, Subramaniyan V, Kokare C, Lum PT, Begum MY, Mani S, Meenakshi DU, Sathasivam KV, Fuloria NK (2021) Drug delivery of natural products through nanocarriers for effective breast cancer therapy: a comprehensive review of literature. Int J Nanomedicine 16:7891–7941. https://doi.org/10.2147/IJN.S328135
Yasmeen, Iqubal MK, Khan M, Agarwal N, Baboota S (2021) Nanoformulations-based advancement in the delivery of phytopharmaceuticals for skin cancer management. J Drug Deliv Sci Technol 66:102912. https://doi.org/10.1016/j.jddst.2021.102912
Zare M, Norouzi Roshan Z, Assadpour E, Jafari SM (2021) Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems. Crit Rev Food Sci Nutr 61:522–534. https://doi.org/10.1080/10408398.2020.1738999
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Dayani, L., Biganeh, H., Rahimi, R. (2023). Nanotechnology in the Formulation and Delivery of Natural Products for Cancer. In: Sobti, R.C., Ganguly, N.K., Kumar, R. (eds) Handbook of Oncobiology: From Basic to Clinical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-99-2196-6_68-1
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