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Digital Surgical Diagnosis and Treatment of Gallbladder Cancer

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Biliary Tract Surgery

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Abstract

Gallbladder cancer refers to a malignant epithelial tumor arising in the gallbladder (the fundus, body and neck of the gallbladder, and the cystic duct), with an overall 5-year survival rate of only 5% (Hueman et al. 2009; Elias et al. 2010; Hundal et al. 2014). In China, the incidence of gallbladder cancer accounts for 0.4% to 3.8% of biliary tract disease, ranking sixth among gastrointestinal cancer. In recent years, the incidence of gallbladder cancer has increased. Like most malignant tumors, gallbladder cancer has hidden early symptoms and nonspecific clinical presentations. However, gallbladder cancer has an aggressive biological nature. Gallbladder cancer may invade several important neighboring organs and adjacent blood vessels due to its anatomical location and strong ability to invade and metastasize. Most patients with gallbladder cancer have advanced cancer when they are diagnosed, and are often associated with liver invasion, lymph node metastasis, distal bile duct invasion, invasion and distant metastasis of the head of the pancreas. Surgical treatment of these patients usually requires R0 resection of multiple organs, which is difficult and risky. This chapter focuses on the application of three-dimensional visualization technology in the treatment of gallbladder cancer combined with hepatectomy and pancreaticoduodenectomy.

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References

  • Amin MB, Edge SB, Greene FL, et al., editors. AJCC cancer staging manual. 8th ed. Cham: Springer; 2017.

    Google Scholar 

  • Chen Y-J. Anatomical characteristics of gallbladder and the metastatic pathway of gallbladder carcinoma infiltration. Chin J Pract Surg. 2011;31(3):207–9.

    CAS  Google Scholar 

  • Doty JR, Cameron JL, Yeo CJ, et al. Cholecystectomy, liver resection, and phylorus preserving pancreaticoduodenectomy for gallbladder cancer: report of five cases. J Gastrointest Surg. 2002;6(5):776–80.

    Article  PubMed  Google Scholar 

  • Edge SB, Compton CC. The American Joint committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.

    Article  PubMed  Google Scholar 

  • Fong Y, Jarnagin W, Blumgart LH. Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention. Ann Surg. 2000;232(4):557–69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fred TB, Fatima C, Raiph HH, et al. WHO classification of tumours of the digestive system. 4th ed. International Agency for Research on Cancer: Lyon; 2010.

    Google Scholar 

  • Goetze TO, Paolucci V. The prognostic impact of positive lymph nodes in stages T1 to T3 incidental gallbladder carcinoma: results of the German Registry. Surg Endosc. 2012;26:1382–9.

    Article  PubMed  Google Scholar 

  • Hueman MT, Vollmer J, Pawlik TM. Evolving treatment strategies for gallbladder. Ann Surg Oncol. 2009;16(8):2101–15.

    Article  PubMed  Google Scholar 

  • Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. [J]. Clin Epidemiol, 2014;6(1):99–109.

    Google Scholar 

  • Isambert M, Leux CS, Métairie, et al. Incidentally-discovered gallbladder cancer: When, why and which reoperation? [J]. Journal of Visceral Surgery, 2011;148(2):e77–84.

    Google Scholar 

  • Jhamb S, Decker C, Romero R, et al. Intrahepatic stones from congenital biliary dilatation. Ochsner J. 2015;15(1):102–5.

    PubMed  PubMed Central  Google Scholar 

  • Kim SJ, Lee JM, Lee JY, et al. Accuracy of preoperative T-staging of gallbladder carcinoma using MDCT. AJR Am J Roentgenol. 2008;190:74–80.

    Article  PubMed  Google Scholar 

  • Kim WS, Choi DW, You DD, et al. Risk factors influencing recurrence, patterns of recurrence, and the efficacy of adjuvant therapy after radical resection for gallbladder carcinoma. J Gastrointest Surg. 2010;14(4):679–87.

    Article  PubMed  Google Scholar 

  • Kim SJ, Lee JM, Lee ES, et al. ***Preoperative staging of gallbladder carcinoma using biliary MR imaging. J Magn Reson Imaging. 2014;

    Google Scholar 

  • Kondo S, Nimura Y, Hayakawa N, et al. Extensive surgery for carcinoma of the gallbladder. Br J Surg. 2002;89:179–84.

    Article  CAS  PubMed  Google Scholar 

  • Lee HK, Park SJ, Yi BH, et al. Imaging features of adult choledochal cysts: a pictorial review. Korean J Radiol. 2009;10(1):71–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mayo SC, Shore AD, Nathan H, et al. National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis. J Gastrointest Surg. 2010;14(10):1578–91. https://doi.org/10.1007/s11605-010-1335-3.

    Article  PubMed  Google Scholar 

  • Mekeel KL, Hemming AW. Surgical Management of Gallbladder Carcinoma: A Review [J]. Journal of Gastrointestinal Surgery. 2007;11(9):1188–93.

    Google Scholar 

  • Miller G, Jarnagin WR. Gallbladder carcinoma. Eur J Surg Oncol. 2008;34(3):306–12. https://doi.org/10.1016/j.ejso.2007.07.206.

    Article  CAS  PubMed  Google Scholar 

  • Miyano T, Yamataka A, Li L. Congenital biliary dilatation. Semin Pediatr Surg. 2000;9(4):187–95.

    Article  CAS  PubMed  Google Scholar 

  • Nakamura S, Nishiyama R, Yokoi Y, et al. Hepatopancreatoduodenectomy for advanced gallbladder carcinoma. Arch Surg. 1994;129(6):625–9.

    Article  CAS  PubMed  Google Scholar 

  • Network NCC. NCCN Clinical Practice Guidelines in Oncology: Hepatobiliary Cancers. 2014.

    Google Scholar 

  • Nimura Y, Hayakawa N, Kamiya J, et al. Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract. Hepato-Gastroenterology. 1991;38(2):170–5.

    CAS  PubMed  Google Scholar 

  • Nishio H, Nagino M, Ebata T, et al. Aggressive surgery for stage IV Gallbladder carcinoma: what are the contraindications? J Hepato-Biliary-Pancreat Surg. 2007;14(40):351–7.

    Article  Google Scholar 

  • Sasaki R, Takeda Y, Hoshikawa K, et al. Long-term results of central inferior (S4a+S5) hepatic subsegmentectomy and pancreatoduodenectomy combined with extended lymphadenectomy for gallbladder carcinoma with subserous or mild liver invasion (pT2-3) and nodal involvement: preliminary report. Hepato-Gastroenterology. 2004;51(55):215–8.

    PubMed  Google Scholar 

  • Shimizu Y, Ohtsuka M, Ito H, et al. Should the extrahepatic bile duct be resected for locally advanced gallbladder cancer? Surgery. 2004;136:1012–7. discussion 1018

    Article  PubMed  Google Scholar 

  • Shimizu H, Kimura F, Yoshidome H, et al. Aggressive surgical approach for stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery classification. J Hepato-Biliary-Pancreat Surg. 2007;14(4):358–65.

    Article  Google Scholar 

  • Shirai Y, Yoshida K, Tsukada K, Muto T. In apparent carcinoma of the gallbladder. An appraisal of a radical second operation after simple cholecystectomy. Ann Surg. 1992;215(4):326–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shirai Y, Wakai T, Sakata J, et al. Regional lymphadenectomy for gallbladder cancer: rational extent, technical details, and patient outcomes. World J Gastroenterol. 2012;18(22):2775–83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tsuji T, Kanemitsu K, Hiraoka T, et al. A new method to establish the rational extent of hepatic resection for advanced gallbladder cancer using dye injection through the cystic artery. HPB (Oxford). 2004;6:33–66.

    Article  CAS  Google Scholar 

  • Tsukada K, Hatakeyama K, Kurosaki I, et al. Outcome of radical surgery for carcinoma of the gallbladder according to the TNM stage. Surgery. 1996;120(5):816–22.

    Article  CAS  PubMed  Google Scholar 

  • Yamaguchi K, Tsuneyoshi M. Subclinical gallbladder carcinoma. Am J Surg. 1992;163(4):382–6.

    Article  CAS  PubMed  Google Scholar 

  • Yoshimitsu K, Honda H, Shinozaki K, et al. Helical CT of the local spread of carcinoma of the gallbladder: evaluation according to the TNM system in patients who underwent surgical resection. AJR Am J Roentgenol. 2002;179:423–8.

    Article  PubMed  Google Scholar 

  • Yoshimitsu K, Nishihara Y, Okamoto D, et al. Magnetic resonance differentiation between T2 and T1 gallbladder carcinoma: significance of subserosal enhancement on the delayed phase dynamic study. Magn Reson Imaging. 2012;30:854–9.

    Article  PubMed  Google Scholar 

  • Yu ZL, Zhang LJ, Fu JZ, et al. Anomalous pancreaticobiliary junction: image analysis and treatment principles. Hepatobiliary Pancreat Dis Int. 2004;3(1):136–9.

    PubMed  Google Scholar 

  • Zhou Y, Zhang Z, Wu L, et al. A systematic review of the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers. HPB (Oxford). 2016;18(1):1–6.

    Article  Google Scholar 

  • Zhu AX, Hong TS, Hezel AF, Kooby DA. Current management of gallbladder carcinoma. Oncologist. 2010;15(2):168–81. https://doi.org/10.1634/theoncologist.2009-0302.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Yingbin Liu & Haibin Liang

  2. Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Jianming Wang & Yan Liu

  3. Zhujiang Hospital, Southern Medical University, Guangzhou, China

    Chihua Fang

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  1. Yingbin Liu
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  2. Haibin Liang
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  3. Jianming Wang
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  4. Yan Liu
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  5. Chihua Fang
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Editor information

Editors and Affiliations

  1. Hepatobiliary Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China

    Chihua Fang

  2. Chinese University of Hong Kong, Princecss of Wales Hospital, Hong Kong, China

    Wan Yee Lau

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Liu, Y., Liang, H., Wang, J., Liu, Y., Fang, C. (2021). Digital Surgical Diagnosis and Treatment of Gallbladder Cancer. In: Fang, C., Lau, W.Y. (eds) Biliary Tract Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-33-6769-2_15

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  • DOI: https://doi.org/10.1007/978-981-33-6769-2_15

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  • Online ISBN: 978-981-33-6769-2

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