Skip to main content

Health Benefits of Mushrooms: An Appraisal

  • Chapter
  • First Online:
Fungal Resources for Sustainable Economy

Abstract

In recent years, the health benefits of mushrooms are being realized in an exponential manner. Mushrooms are an interesting group of organisms, which attracted and distracted people alike since times immemorial. They appear and disappear mysteriously. Many legends are associated with them. Their potential in medicine for health benefits was appreciated only during the late 1990s. When their medicinal properties were recognized, their importance immediately gained significance, and now they are at the forefront of the treatment of some dreaded diseases. Their potentialities in the health sector have grown tremendously due to the identification and isolation of bioactive compounds, which are being explored further as nutraceuticals. This appreciation was first limited to a few well-known species, but now a consensus seems to have emerged that every mushroom possesses one or other traits which accrue health benefits to man. There are around 7000 edible species among 16,000 mushroom species recorded the world over. Of these, around 3000 are perhaps the prime edible species of which around 200 have been experimentally grown, 100 economically cultivated, and 30 commercially cultivated in one or other parts of the world, and about 6 species are grown on the industrial scale. Further, around two dozen species have been investigated for their nutraceutical traits. In the near future, it is anticipated that the mushrooms possessing medicinal properties are likely to become a potential source of new biological drugs for counteracting lifestyle diseases. The health benefits of mushrooms, nutraceuticals, and pharmaceuticals derived from them have been discussed in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abraham SP, Nair LN (1987) Nutritive value of two edible mushrooms from Kashmir. Kavaka 15(1–2):90–92

    Google Scholar 

  • Acharya K, Das K, Paloi S, Dutta AK, Hembrom ME et al (2017) Exploring a novel edible mushroom Ramaria subalpina: chemical characterization and antioxidant activity. Pharmacogn J 9(1):30–34

    Article  CAS  Google Scholar 

  • Adenipekun CO, Lawal R (2012) Uses of mushrooms in bioremediation: a review. Biotechnol Mol Biol Rev 7(3):62–68

    CAS  Google Scholar 

  • Agnihotri S, Dutt D, Tyagi CH, Kumar A, Upadhyaya JS (2010) Production and biochemical characterization of a novel cellulase-poor alkali thermo-tolerant xylanase from Coprinellus disseminatus SW-1 NTCC 1165. World J Microbiol Biotechnol 26:1349–1359

    Article  CAS  Google Scholar 

  • Ahmad N, Bansal AK, Kidwai JR (1984) Effect of PHA-B fraction of Agaricus bisporus lectin on insulin release and 45Ca2C uptake by islet of Langerhans in vitro. Acta Diabetol 21:63–70

    CAS  Google Scholar 

  • Ajith TA, Janardhanan KK (2007) Indian medicinal mushrooms as a source of antioxidant and antitumor agents. J Clin Biochem Nutr 40:157–162

    Article  Google Scholar 

  • Al-Fatimi MA, Julich WD, Jansen R, Lindequist U (2006) Bioactive components of the traditionally used mushroom Podaxis pistillaris. Evid Based Complement Alternat Med 3(1):87–92

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Allen SJ, Dawbarn D (2006) Clinical relevance of the neurotrophins and their receptors. Clin Sci (Lond) 110:175–191

    Article  CAS  PubMed  Google Scholar 

  • Anastasi A, Vizzini A, Prigione V, Varese GC (2009) Wood degrading fungi: morphology, metabolism and environmental applications. In: Varma A, Chauhan AK (eds) A textbook of molecular biotechnology. I.K. International, Mumbai, pp 957–993

    Google Scholar 

  • Atri NS, Kumari B, Kumar S, Upadhyay RC, Gulati A, Lata GA (2016) Nutritional profile of wild edible mushrooms of North India. In: Deshmukh SK, Misra JK, Tiwari JP, Papp T (eds) Fungi applications and management strategies. CRC Press, Taylor and Francis Group, Boca Raton, pp 372–395

    Google Scholar 

  • Atri NS, Sharma YP, Kaul SK, Mridu (2019) Wild edible mushrooms of North West Himalaya—their nutritional and sociobiological aspects. In: Satyanarayan T, Das SK, Johri BN (eds) Microbial diversity: ecosystem sustainability and biotechnological applications. Springer Nature, Singapore, pp 533–563

    Chapter  Google Scholar 

  • Azeez S, Pandey M, Jasmin MR, Rachitha R, Satisha GC, Roy TK, Chandrashekara C, Shivashankara KS (2020) Amino acid profile of eighteen different edible macrofungal species/isolates. J Hortic Sci 15(2):207–220

    Article  Google Scholar 

  • Babu DR, Rao GN (2013) Antioxidant properties and electrochemical behavior of cultivated commercial Indian edible mushrooms. J Food Sci Technol 50(2):301–308

    Article  CAS  PubMed  Google Scholar 

  • Babu DR, Pandey M, Rao GN (2012) Antioxidant and electrochemical properties of cultivated Pleurotus spp. and their sporeless/low sporing mutants. J Food Sci Technol 51(11):3317–3324

    Article  PubMed  PubMed Central  Google Scholar 

  • Badalyan SM (2012) Medicinal aspects of edible ectomycorrhizal mushrooms. In: Zambonelli A, Bonitо G (eds) Edible ectomycorrhizal mushrooms, current knowledge and future prospects, vol 34. Springer, Berlin, pp 317–334

    Chapter  Google Scholar 

  • Badole SL, Shah SN, Patel NM, Thakurdesai PA, Bodhankar SL (2006) Hypoglycemic activity of aqueous extract of Pleurotus pulmonarius in alloxan-induced diabetic mice. Pharm Biol 44(6):421–425

    Article  Google Scholar 

  • Baldrian P (2008) Wood-inhabiting ligninolytic basidiomycetes in soils: ecology and constraints for applicability in bioremediation. Fungal Ecol 1:4–12

    Article  Google Scholar 

  • Bano Z, Bhagya S, Srivastava HC (1981a) Essential amino acid composition and proximate analysis of the mushroom Pleurotus eous and P. florida. Mush News Lett Tropics 1(3):6–10

    Google Scholar 

  • Bano Z, Nagaraaj N, Vibhakar KV, Kapur OP (1981b) Minerals and the heavy metal contents in the sporophores of Pleurotus species. Mush News Lett Top 2:3–7

    Google Scholar 

  • Barreira JCM, Oliveira MBPP, Ferreira ICFR (2014) Development of a novel methodology for the analysis of ergosterol in mushrooms. Food Anal Methods 7:217–223

    Article  Google Scholar 

  • Barros L, Cruz T, Baptista P, Estevinho LM, Ferreira ICFR (2008) Wild and commercial mushrooms as source of nutrients and nutraceuticals. Food Chem Toxicol 46(8):2742–2747

    Article  CAS  PubMed  Google Scholar 

  • Bastiaan-Net S, Chanput W, Hertz A, Zwittink RD, Mes JJ, Wichers HJ (2013) Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs). Int Immunopharmacol 15:167–175

    Article  CAS  PubMed  Google Scholar 

  • Benjamin TM, Anuradha (1991) Comparison of nutritive value of the common mushroom varieties. In: Proc of Natn Symp on Musk Ind Mush, pp 226–227

    Google Scholar 

  • Bensky D, Gamble A (1993) Chinese herbal medicine: materia medica. Eastland Press, Seattle, p 581

    Google Scholar 

  • Bhosle S, Bapat G, Vaidya J, Garad S, Hiralal S (2010) Antimicrobial activity of terpenoid extracts from Ganoderma samples. Int J Pharm Life Sci 1(4):234–240

    Google Scholar 

  • Bisaria R, Madan M, Bisaria VS (1987) Biological efficiency and nutritive value of Pleurotus sajor-caju cultivated on different agro-wastes. Biol Wastes 19:239–255

    Article  CAS  Google Scholar 

  • Biswas G, Acharya K (2013) Hypoglycemic activity of ethanolic extract of astraeus hygrometricus (pers.) morg. in alloxan-induced diabetic mice 5. Int J Pharm Pharm Sci 5(Suppl 1):391–394

    Google Scholar 

  • Bonilla E (2000) Huntington disease. A review. Invest Clin 41:117–141

    CAS  PubMed  Google Scholar 

  • Browne SE, Beal MF (2006) Oxidative damage in Huntington’s disease pathogenesis. Antioxid Redox Signal 8:2061–2073

    Article  CAS  PubMed  Google Scholar 

  • Cantarella G, d’Acunzo F, Galli C (2003) Determination of laccase activity in mixed solvents: comparison between two chromogens in a spectrophotometric assay. Biotechnol Bioeng 82(4):395–398

    Article  CAS  PubMed  Google Scholar 

  • Cardwell G, Bornman JF, James AP, Black LJ (2018) A review of mushrooms as a potential source of dietary Vitamin D. Nutrients 13(10):1498–1509

    Article  Google Scholar 

  • Chaga GS, Medin AS, Chaga SG, Porath JO (1992) Isolation and characterization of catalase from Penicillium chrysogenum. J Chromatogr A 604:177–183

    Article  CAS  Google Scholar 

  • Chang ST, Buswell JA (1996) Mushroom nutriceuticals. World J Microbiol Biotechnol 12:473–476

    Article  CAS  PubMed  Google Scholar 

  • Chang ST, Miles PG (eds) (1987) Edible mushrooms and their cultivation. Chinese University Press, Hong Kong

    Google Scholar 

  • Chang ST, Miles PG (2004) The nutritional attributes of edible mushrooms. In: Mushrooms: cultivation, nutritional value, medicinal effect, and environmental impact. CRC Press, Boca Raton, pp 27–38

    Chapter  Google Scholar 

  • Chang HH, Sheu F (2007) A novel fungal immunomodulatory protein (PCP) isolated from Poria cocos activates mouse peritoneal macrophage involved in toll-like receptor 4. FASEB J 21:702–715

    Article  Google Scholar 

  • Chen W, Zhao Z, Chen SF, Li YQ (2008) Optimization for the production of exopolysaccharide from Fomes fomentarius in submerged culture and its antitumor effect in vitro. Bioresour Technol 99(8):3187–3194

    Article  CAS  PubMed  Google Scholar 

  • Chen WY, Chang CY, Li JR, Wang JD, Wu CC et al (2018) Anti-inflammatory and neuroprotective effects of fungal immunomodulatory protein involving microglial inhibition. Int J Mol Sci 19(11):3678

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheng CR, Yue QX, Wu ZY, Song XY, Tao SJ et al (2010) Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry 71(13):1579–1585

    Article  CAS  PubMed  Google Scholar 

  • Cheung WM, Hui WS, Chu PW, Chiu SW, Ip NY (2000) Ganoderma extract activates MAP kinases and induces neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett 486:291–296

    Article  CAS  PubMed  Google Scholar 

  • Cheung LM, Cheung PCK, Ooi VEC (2003) Antioxidant activity and total phenolics of edible mushroom extracts. Food Chem 81:249–255

    Article  CAS  Google Scholar 

  • Chirinang P, Intarapichet K (2009) Amino acids and antioxidant properties of the oyster mushrooms, Pleurotus ostreatus and Pleurotus sajor-caju. Sci Asia 35:326–331

    Article  CAS  Google Scholar 

  • Cho EJ, Hwang HJ, Kim SW, Oh JY, Baek YM et al (2007) Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice. Appl Microbiol Biotechnol 75(6):1257–1265

    Article  CAS  PubMed  Google Scholar 

  • Choudhary S, Kumar P, Malik J (2013) Plants and phytochemicals for Huntington’s disease. Pharmacogn Rev 7(14):81–91

    Article  PubMed  PubMed Central  Google Scholar 

  • Cong WR, Xu H, Liu Y, Li QZ, Li W, Zhou XW (2014) Production and functional characterization of a novel fungal immunomodulatory protein FIP-SN15 shuffled from two genes of Ganoderma species. Appl Microbiol Biotechnol 98:5967–5975

    Article  CAS  PubMed  Google Scholar 

  • Cramer H, Warter JM, Renaud B (1984) Analysis of neurotransmitter metabolites and adenosine 3,5-monophosphate in the CSF of patients with extra pyramidal motor disorders. Adv Neurol 40:431–435

    CAS  PubMed  Google Scholar 

  • Crisan EV, Sands A (1978) Nutritional values. In: Chang ST, Hayes WA (eds) The biology and cultivation of edible mushrooms. Academic Press, New York, pp 137–168

    Chapter  Google Scholar 

  • Das K (2010) Diversity and conservation of wild mushrooms in Sikkim with special reference to Barsey Rhododendron Sanctuary. NeBIO 1(2):1–13

    Google Scholar 

  • DaSilva EJ, Buswell JA, Chang ST (2003) Bioceuticals—healthcare aids. Agrofood Ind Hi-Tec 14:21–25

    Google Scholar 

  • Deacon J (2006) Fungal biology, 4th edn. Wiley-Blackwell, Malden

    Google Scholar 

  • Delanty N, Dichter MA (2000) Antioxidant therapy in neurologic disease. Arch Neurol 57:1265–1270

    Article  CAS  PubMed  Google Scholar 

  • Diez VA, Alvarez AM (2001) Compositional and nutritional studies on two wild edible mushrooms from Northwest Spain. Food Chem 75:417–442

    Article  CAS  Google Scholar 

  • DiFiglia T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI (2006) Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311:1471–1474

    Article  Google Scholar 

  • Ding Z, Lu Y, Lu Z, Lv F, Wang Y, Bie X et al (2010) Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats. Food Chem 121:39–43

    Article  CAS  Google Scholar 

  • Dong CH, Yao YJ (2008) In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis. LWT Food Sci Technol 41:669–677

    Article  CAS  Google Scholar 

  • Dulger B, Gonuz A (2004) Antimicrobial activity of certain plants used in Turkish traditional medicine. Asian J Plant Sci 3:104–107

    Google Scholar 

  • Duran N, Esposito E (2000) Potential applications of oxidative enzymes and phenoloxidase-like compounds in wastewater and soil treatment: a review. Appl Catal B Environ 28(2):83–99

    Article  CAS  Google Scholar 

  • Eik LF, Naidu M, David P, Wong KH et al (2012) Lignosus rhinocerus (Cooke) Ryvarden: a medicinal mushroom that stimulates neurite outgrowth in PC-12 cells. Evid Based Complement Alternat Med 2012:320308

    Article  PubMed  Google Scholar 

  • Ejike UC, Chan CJ, Okechukwu PN, Lim RLH (2020) New advances and potentials of fungal immunomodulatory proteins for therapeutic purposes. Crit Rev Biotechnol 40(8):1172–1190

    Article  CAS  PubMed  Google Scholar 

  • El Dine RS, El Halawany AM, Ma CM, Hattori M (2008) Anti-HIV-1 protease activity of lanostane triterpenes from the Vietnamese mushroom Ganoderma colossum. J Nat Prod 71(6):1022–1026

    Article  PubMed  Google Scholar 

  • Elisashvili V, Kachlishvili E, Tsiklauri N et al (2009) Lignocellulose-degrading enzyme production by white-rot basidiomycetes isolated from the forests of Georgia. World J Microbiol Biotechnol 25:331–339

    Article  CAS  Google Scholar 

  • Essa MM, Moghadas M, Ba-Omar T et al (2019) Protective effects of antioxidants in Huntington’s disease: an extensive review. Neurotoxicity Res 35:739–774

    Article  CAS  Google Scholar 

  • Esteve MJ, Frigola RFA, Garcia-Cantabella JM (2001) Simultaneous determination of thiamine and riboflavin in mushrooms by liquid chromatography. J Agric Food Chem 49:1450–1454

    Article  CAS  PubMed  Google Scholar 

  • Evsenko MS, Shashkov AS, Avtonomova AV, Krasnopolskaya LM, Usov AI (2009) Polysaccharides of basidiomycetes. Alkali-soluble polysaccharides from the mycelium of white rot fungus Ganoderma lucidum (Curt.: Fr.) P. Karst. Biochemistry (Moscow) 74(5):533–542

    Article  CAS  PubMed  Google Scholar 

  • Fan Y, Flurkey WH (2004) Purification and characterization of tyrosinase from gill tissue of Portabella mushrooms. Phytochemistry 65:671–678

    Article  CAS  PubMed  Google Scholar 

  • Ferreira ICFR, Barros L, Abreu RMV (2009) Antioxidants in wild mushrooms. Curr Med Chem 16:1543–1560

    Article  CAS  PubMed  Google Scholar 

  • Ferreira ICFR, Vaz JA, Vasconcelos MH, Martins A (2010) Compounds from wild mushrooms with antitumor potential. Anti-Cancer Agents Med Chem 10:424–436

    Article  CAS  Google Scholar 

  • Furlani RPZ, Godoy HT (2008) Vitamins B1 and B2 contents in cultivated mushrooms. Food Chem 106:816–819

    Article  CAS  Google Scholar 

  • Gao Y, Zhou SH, Chen G, Dai X, Ye J (2003) A phase I/II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. extract (ganopoly) in patients with advanced cancer. Int J Med Mushroom 4:207–214

    Google Scholar 

  • Garcha HS, Phutela HS (1989) Mushrooms—a novel and economic and nutrient source for rural people. In: Trivedi ML, Gill BS, Saini SS (eds) Plant science research in India. Today and Tomorrows Printers and Publishers, New Delhi, pp 585–594

    Google Scholar 

  • Garcia-Molina F, Hiner ANP, Fenoll LG et al (2005) Mushroom tyrosinase: catalase activity, inhibition, and suicide inactivation. J Agric Food Chem 53:3702–3709

    Article  CAS  PubMed  Google Scholar 

  • Garrab M, Edziri H, Mokni RE, Mastouri M et al (2019) Phenolic composition, antioxidant and anticholinesterase properties of the three mushrooms Agaricus silvaticus Schaeff., Hydnum rufescens Pers. and Meripilus giganteus (Pers.) Karst. in Tunisia. South Afr J Bot 124:359–363

    Article  CAS  Google Scholar 

  • Garzillo AMV, Colao MC, Caruso C et al (1998) Laccase from the white-rot fungus Trametes trogii. Appl Microbiol Biotechnol 49:545–551

    Article  CAS  PubMed  Google Scholar 

  • Giri S, Biswas G, Pradhan P, Mandal SC, Acharya K (2012) Antimicrobial activities of basidiocarps of wild edible mushrooms of West Bengal, India. Int J Pharm Tech Res 4(4):1554–1560

    Google Scholar 

  • Gouzi H, Leboukh M, Bouchouka E (2013) Antioxidant and antiradical properties of methanolic extracts from Algerian wild edible desert truffles (Terfezia and Tirmania, Ascomycetes). Int J Med Mushrooms 15(5):471–486

    Article  CAS  PubMed  Google Scholar 

  • Gray AM, Flatt PR (1998) Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J Endocrinol 157:259–266

    Article  CAS  PubMed  Google Scholar 

  • Greeshma P, Ravikumar KS, Neethu MN, Pandey M et al (2016) Antioxidant, anti-inflammatory, and antitumor activities of cultured mycelia and fruiting bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes). Int J Med Mushrooms 18(3):235–244

    Article  PubMed  Google Scholar 

  • Guillamon E, Garcia-Lafuente A, Lozano M et al (2010) Edible mushrooms: role in the prevention of cardiovascular diseases. Fitoterapia 81(7):715–723

    Article  CAS  PubMed  Google Scholar 

  • Guillot J, Konska G (1997) Lectins in higher fungi. Biochem Syst Ecol 25:203–230

    Article  CAS  Google Scholar 

  • Gulati A, Atri NS, Sharma SK, Sharma BM (2011) Nutritional studies on five wild Lentinus species from North-West India. World J Dairy Food Sci 6:140–145

    Google Scholar 

  • Gyawali R, Ibrahim SA (2014) Natural products as antimicrobial agents. Food Control 46:412–429

    Article  CAS  Google Scholar 

  • Halaouli S, Asther M, Sigoillot JC et al (2006) Fungal tyrosinases: new prospects in molecular characteristics, bioengineering and biotechnological applications. J Appl Microbiol 100:219–232

    Article  CAS  PubMed  Google Scholar 

  • Han C, Liu T (2009) A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium. Biol Trace Elem Res 127(2):177–182

    Article  CAS  PubMed  Google Scholar 

  • Han C, Yuan J, Wang Y, Li L (2006) Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium. J Trace Elem Med Biol 20(3):191–196

    Article  CAS  PubMed  Google Scholar 

  • Han SSR, Cho CK, Lee YW, Yoo HS (2009) Antimetastatic and immunomodulating effect of water extracts from various mushrooms. J Acupunct Meridian Stud 2(3):218–227

    Article  PubMed  Google Scholar 

  • Han XQ, Wu XM, Chai XY, Chen D et al (2011) Isolation, characterization and immunological activity of a polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito. Food Res Int 44:489–493

    Article  CAS  Google Scholar 

  • Hassan MAA, Rouf R, Tiralongo E, May TW, Tiralongo J (2015) Mushroom lectins: specificity, structure and bioactivity relevant to human disease. Int J Mol Sci 16:7802–7838

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hayes WA (1975) The protein in mushrooms. Mushroom J 30:204–206

    Google Scholar 

  • Hayes WA, Haddad N (1976) The food value of the cultivated mushroom and its importance to the mushroom industry. Mushroom J 40:104–110

    CAS  Google Scholar 

  • Hearst M, Nelson D, McCollum G, Ballard LM et al (2010) Antimicrobial properties of protein extracts from wild mushroom fungi and native plant species against hospital pathogens. J Pharmacognosy Phytother 2(8):103–107

    Google Scholar 

  • Hilden K, Makela MR, Lankinen P, Lundell T (2013) Agaricus bisporus and related Agaricus species on lignocellulose: production of manganese peroxidase and multicopper oxidases. Fungal Genet Biol 55:32–41

    Article  CAS  PubMed  Google Scholar 

  • Horio H, Ohtsuru M (2001) Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol 47:7–63

    Article  Google Scholar 

  • Hossain MF, Rashid M, Sidhu R, Mullins R, Mayhew SL (2019) A simplified, specific HPLC method of assaying thiamine and riboflavin in mushrooms. Int J Food Sci 2019:8716986

    Article  PubMed  PubMed Central  Google Scholar 

  • Hsiao Y, Huang Y, Tang S, Shieh G et al (2008) Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through phosphatidylinositol 3-kinase signal pathway. Process Biochem 43:423–430

    Article  CAS  Google Scholar 

  • Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY (1997) Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem J 323:557–565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hu HL, van den Brink J, Gruben BS et al (2011) Improved enzyme production by co-cultivation of Aspergillus niger and Aspergillus oryzae and with other fungi. Int Biodeterior Biodegrad 65:248–252

    Article  CAS  Google Scholar 

  • Huang SJ, Lin CP, Tsai SY (2015) Vitamin D2 content and antioxidant properties of fruit body and mycelia of edible mushrooms by UV-B irradiation. J Food Compos Anal 42:38–45

    Article  CAS  Google Scholar 

  • Huang G, Cai W, Xu B (2017) Vitamin D2, ergosterol, and vitamin B2 content in commercially dried mushrooms marketed in China and increased vitamin D2 content following UV-C irradiation. Int J Vitam Nutr Res 87(5–6):1–10

    PubMed  Google Scholar 

  • Hughes DH, Lynch DL, Somers GF (1958) Chromatographic identification of the amino acids and carbohydrates in the cultivated mushroom Agaricus campestris L. ex. Fries. J Agric Food Chem 6:850–853

    Article  CAS  Google Scholar 

  • Huie CW, Di X (2004) Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B 812:241–257

    Article  CAS  Google Scholar 

  • Ishikawa NK, Fukushi Y, Yamaji K, Tahara S, Takahashi K (2001) Antimicrobial cuparene-type sesquiterpenes, Enokipodins C and D, from a mycelial culture of Flammulina velutipes. J Nat Prod 64:932–934

    Article  CAS  PubMed  Google Scholar 

  • Ismaya WT, Rozeboom HJ, Weijn A et al (2011) Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone. Biochemistry 50(24):5477–5486

    Article  CAS  PubMed  Google Scholar 

  • Ismaya WT, Tandrasasmita OM, Sundari S et al (2017) The light subunit of mushroom Agaricus bisporus tyrosinase: its biological characteristics and implications. Int J Biol Macromol 102:308–314

    Article  CAS  PubMed  Google Scholar 

  • Iyer G, Chattoo BB (2003) Purification and characterization of laccase from the rice blast fungus, Magnaporthe grisea. FEMS Microbiol Lett 227:121–126

    Article  CAS  PubMed  Google Scholar 

  • Jagtap SS, Dhiman SS, Kim TS, Li J, Kang YC, Lee JK (2013) Characterization of a β-1,4-glucosidase from a newly isolated strain of Pholiota adiposa and its application to the hydrolysis of biomass. Biomass Bioenergy 54:181–190

    Article  CAS  Google Scholar 

  • Jana KK, Purkayastha RP (1987) Nutritional effects on the growth of two edible fungi and their nutritive values. Ind Mush Sci 2:305–308

    Google Scholar 

  • Jandaik CL, Kapoor JN (1976) Amino acid composition of Pleurotus sajor caju (Fr.) Singer. Mush J 41:145–156

    Google Scholar 

  • Jandaik CL, Bhandari AR, Arora CL, Rangad CO (1978) Chemical composition of some edible fungi. Mush Sci 10:685–688

    Google Scholar 

  • Jasinghe VJ, Perera CO (2006) Ultraviolet irradiation: the generator of Vitamin D2 in edible mushrooms. Food Chem 95(4):638–643

    Article  CAS  Google Scholar 

  • Jayasuriya WJ, Suresh TS, Abeytunga D, Fernando GH, Wanigatunga CA (2012) Oral hypoglycemic activity of culinary-medicinal mushrooms Pleurotus ostreatus and P. cystidiosus (higher basidiomycetes) in normal and alloxan-induced diabetic Wistar rats. Int J Med Mushrooms 14(4):347–355

    Article  CAS  PubMed  Google Scholar 

  • Jeong YT, Yang BK, Jeong SC, Kim SM et al (2008) Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity. Phytother Res 22(5):614–619

    Article  CAS  PubMed  Google Scholar 

  • Jeong SC, Jeong YT, Yang BK, Islam R et al (2010) White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res 30(1):49–56

    Article  CAS  PubMed  Google Scholar 

  • Johnsy G, Davidson SS, Dinesh MG, Kaviyarasan V (2011) Nutritive value of edible wild mushrooms collected from the Western Ghats of Kanyakumari district. Bot Res Int 4:69–74

    CAS  Google Scholar 

  • Johri A, Beal MF (2012) Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther 342:619–630

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Judith I (1989) Nutritional and utilizable value of some cultivated mushrooms. Mush Sci 12(1):295–304

    Google Scholar 

  • Juturu V, Wu JC (2014) Microbial cellulases: engineering, production and applications. Renew Sustain Energy Rev 33:188–203

    Article  CAS  Google Scholar 

  • Kalac P (2016) Edible mushrooms chemical composition and nutritional value. Elsevier, New York

    Google Scholar 

  • Kanagasabapathy G, Chua KH, Malek SN, Vikineswary S, Kuppusamy UR (2014) AMP-activated protein kinase mediates insulin-like and lipo-mobilising effects of β-glucan-rich polysaccharides isolated from Pleurotus sajor-caju (Fr.), Singer mushroom, in 3T3-L1 cells. Food Chem 145:198–204

    Article  CAS  PubMed  Google Scholar 

  • Kanda K, Sata T, Ishii S, Enei H, Ejiri S (1996) Purification and properties of tyrosinase isozymes from the gill of Lentinus edodes fruiting body. Biosci Biotechnol Biochem 60:1273–1278

    Article  CAS  PubMed  Google Scholar 

  • Karwa A, Rai M (2009) Mycoenhancing the potential of synthetic antibiotics using wild mushrooms: first report. In: Proceedings of the 5th international medicinal mushroom conference. Mycological Society of China, Nantong, pp 167–172

    Google Scholar 

  • Kaul TN (1978) Nutritive value of some edible Morchellaceae. Ind J Mush 4:26–34

    Google Scholar 

  • Kawagishi H, Zhuang C (2008) Compounds for dementia from Hericium erinaceum. Drugs Future 33(2):149–155

    Article  CAS  Google Scholar 

  • Kawai H, Sugahara T, Matsuzawa M et al (1986) Mineral contents in edible mushrooms. Nippon Shokuhin Kogyo Gakkaishi 33(4):250–255

    Article  CAS  Google Scholar 

  • Keflie TS, Nolle N, Lambert C, Nohr D, Biesalski HK (2019) Impact of the natural resource of UVB on the content of vitamin D2 in oyster mushroom (Pleurotus ostreatus) under subtropical settings. Saudi J Biol Sci 26(7):1724–1730

    Article  CAS  PubMed  Google Scholar 

  • Keles A, Koca I, Genccelep H (2011) Antioxidant properties of wild edible mushrooms. J Food Proc Technol 2:1–6

    Google Scholar 

  • Khader V, Nayana P (1981) Nutritional studies on paddy straw mushroom (Volvariella volvacea). Ind J Mush 1:18–20

    Google Scholar 

  • Khanna PK, Garcha HS (1984) Pleurotus mushrooms—a source of food protein. Mush News Lett Tropics 4:9–14

    Google Scholar 

  • Khatua S, Paul S, Acharya K (2013) Mushroom as the potential source of new generation of antioxidant: a review. Res J Pharm Technol 6(5):496–505

    Google Scholar 

  • Khatun S, Bandopadhyay S, Mitra S, Roy P et al (2009) Nutraceutical and antioxidative properties of three species of Pleurotus mushrooms. Proc. 5th Int. Medicinal Mushroom, Ganoderma lucidum (W. Curt. Fr.) P. Karst. (Aphyllophoromycetideae) from Iran. Int J Med Mushrooms 10(4):345–349

    Google Scholar 

  • Khurana ML, Kaul TN, Kachroo L (1987) Nutritional value of wild edible mushrooms from Kashmir-1. In: Kaul TN, Kapoor BM (eds) Indian mushroom sciences II. Regional Research Laboratory, Jammu, pp 184–189

    Google Scholar 

  • Kiho T, Sobue S, Ukai S (1994a) Structural features and hypoglycemic activities of two polysaccharides from a hot-water extract of Agrocybe cylindracea. Carbohydr Res 251:81–87

    Article  CAS  PubMed  Google Scholar 

  • Kiho T, Tsujimura Y, Sakushima M, Usui S, Ukai S (1994b) Polysaccharide in fungi. XXIII. Hypoglycemic activity of an acidic polysaccharide (AC) from Tremella fuciformis. Yakugaku Zasshi 114:308–315

    Article  CAS  PubMed  Google Scholar 

  • Kiho T, Morimoto H, Sakushima M, Usui S, Ukai S (1995) Polysaccharides in fungi. XXXV. Antidiabetic activity of an acidic polysaccharide from the fruiting bodies of Tremella aurantia. Biol Pharm Bull 18:1627–1629

    Article  CAS  PubMed  Google Scholar 

  • Kiho T, Morimoto H, Kobayashi T, Usui S et al (2000) Effect of a polysaccharide (TAP) from the fruiting bodies of Tremella aurantia on glucose metabolism in mouse liver. Biosci Biotechnol Biochem 64:417–419

    Article  CAS  PubMed  Google Scholar 

  • Kim TW, Tanzi RE (1998) Neuronal intra nuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout? Neuron 21:657–659

    Article  CAS  PubMed  Google Scholar 

  • Kim DH, Yang BK, Jeong SC et al (2001) A preliminary study on the hypoglycemic effect of the exo-polymers produced by five different medicinal mushrooms. J Microbiol Biotechnol 11:167–171

    CAS  Google Scholar 

  • Kim HM, Kang JS, Kim JY, Park SK et al (2010a) Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. Int Immunopharmacol 10(1):72–78

    Article  PubMed  Google Scholar 

  • Kim HS, Kim JY, Kang JS, Kim HM, Kim YO et al (2010b) Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. Food Chem Toxicol 48:1926–1933

    Article  CAS  PubMed  Google Scholar 

  • King RB, Sheldon JK, Long GM (1997) Practical environmental bioremediation: the field guide, 2nd edn. Lewis Publishers, Boca Raton

    Google Scholar 

  • Kirk PM, Cannon PF, Minter DW, Stalpers JA (2008) Ainsworth & Bisby’s dictionary of the fungi, 10th edn. CAB International, Wallingford

    Book  Google Scholar 

  • Kitzberger CSG Jr, Smania A, Pedrosa RC, Ferreira SRS (2007) Antioxidant and antimicrobial activities of shiitake (Lentinula edodes) extracts obtained by organic solvents and supercritical fluids. J Food Eng 80:631–638

    Article  CAS  Google Scholar 

  • Klaus A, Miomir N (2007) Influence of the extracts isolated from Ganoderma lucidum mushroom on some microorganisms. Proc Nat Sci Matica Srpska Novi Sad 113:219–226

    Article  Google Scholar 

  • Kohda H, Tokumoto W, Sakamoto K et al (1985) The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. Chem Pharm Bull 33(4):1367–1374

    Article  CAS  Google Scholar 

  • Kong X, Zhang J, Han X, Zhang P et al (2013) High-yield production in Escherichia coli of fungal immunomodulatory protein isolated from Flammulina velutipes and its bioactivity assay in vivo. Int J Mol Sci 14(2):2230–2241

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Konska G (2006) Lectins of higher fungi (macromycetes)—their occurrence, physiological role and biological activity. Int J Med Mushrooms 8:19–30

    Article  Google Scholar 

  • Koyyalamudi SR, Jeong SC, Pang G, Teal A, Biggs T (2011) Concentration of vitamin D2 in white button mushrooms (Agaricus bisporus) exposed to pulsed UV light. J Food Compos Anal 24(7):976–979

    Article  CAS  Google Scholar 

  • Kozarski M, Klaus A, Niksic M, Jakovljevic D et al (2011) Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus. Food Chem 129:1667–1675

    Article  CAS  Google Scholar 

  • Kozarski M, Klaus A, Niksic M, Vrvic MM et al (2012) Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor. J Food Compos Anal 26:144–153

    Article  CAS  Google Scholar 

  • Krishnan G, Pruthi JS (1977) Nutritional quality of tropical paddy straw mushroom. Ind Food Peker 31:14

    Google Scholar 

  • Kubo K, Nanba H (1997) Anti-hyperliposis effect of Maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 20:781–785

    Article  CAS  PubMed  Google Scholar 

  • Kubo K, Aoki H, Nanba H (1994) Antidiabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull 17:1106–1110

    Article  CAS  PubMed  Google Scholar 

  • Kuhad RC, Mehta G, Gupta R, Sharma KK (2010) Fed batch enzymatic saccharification of newspaper cellulosics improves the sugar content in the hydrolysates and eventually the ethanol fermentation by Saccharomyces cerevisiae. Biomass Bioenergy 34(8):1189–1194

    Article  CAS  Google Scholar 

  • Kumar A, Sharma KK, Kumar P, Ramchiary N (2015) Laccase isozymes from Ganoderma lucidum MDU-7: isolation, characterization, catalytic properties and differential role during oxidative stress. J Mol Catal B Enzym 113:68–75

    Article  CAS  Google Scholar 

  • Kumari D, Reddy MS, Upadhyay RC (2011) Nutritional composition and antioxidant activities of 18 different wild Cantharellus mushrooms of northwestern Himalayas. Food Sci Technol Int 17(6):557–567

    Article  CAS  PubMed  Google Scholar 

  • Kumari B, Upadhyay RC, Atri NS (2013) Evaluation of nutraceutical components and antioxidant potential of north Indian wild culinary-medicinal Termitophilous mushrooms. Int J Med Mushrooms 15(2):191–197

    Article  PubMed  Google Scholar 

  • Kunamneni A, Plou FJ, Ballesteros A, Alcalde M (2008) Laccases and their applications: a patent review. Recent Pat Biotechnol 2:10–24

    Article  CAS  PubMed  Google Scholar 

  • Kurniawati S, Nicell JA (2005) Kinetic model of laccase-catalyzed oxidation of aqueous phenol. Biotechnol Bioeng 91(1):114–123

    Article  CAS  PubMed  Google Scholar 

  • Kurushima H, Kodama N, Nanba H (2000) Activities of polysaccharides obtained from Grifola frondosa on insulin-dependent diabetes mellitus induced by streptozotocin in mice. Mycoscience 41:473–480

    Article  CAS  Google Scholar 

  • Lai MN, Ng LT (2013) Antioxidant and antiedema properties of solid-state cultured honey mushroom, Armillaria mellea (higher Basidiomycetes), extracts and their polysaccharide and polyphenol contents. Int J Med Mushrooms 15(1):1–8

    Article  CAS  PubMed  Google Scholar 

  • Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP et al (2013) Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms 15:539–554

    Article  PubMed  Google Scholar 

  • Lakhanpal TN, Rana M (2005) Medicinal and nutraceutical genetic resources of mushrooms. Plant Genet Resour 3:288–303

    Article  CAS  Google Scholar 

  • Lakhanpal TN, Shad OS, Rana M (2010) Biology of Indian Morels. IK International Publishing House, Mumbai

    Google Scholar 

  • Lakshmi B, Tilak JC, Adhikari S, Devasagayam TPA, Janardhanan KK (2004) Evaluation of antioxidant activity of selected Indian mushrooms. Pharm Biol 42:179–185

    Article  Google Scholar 

  • Lamar RT, White RB (2001) Mycoremediation: commercial status and recent developments. In: Magar VS, Von Fahnestock MF, Leeson A (eds) Proceedings sixth international symposium on in situ and on-site bioremediation, San Diego, pp 263–278

    Google Scholar 

  • Latiff LA, Daran ABM, Mohamed AB (1996) Relative distribution of minerals in the pileus and stalk of some selected edible mushrooms. Food Chem 56(2):115–121

    Article  CAS  Google Scholar 

  • Lee IK, Yun BS, Cho SM, Kim WG, Kim JP, Ryoo IJ (1996) Betulinans A and B, two benzoquinone compounds from Lenzitesbetulina. J Nat Prod 59:1090–1092

    Article  CAS  PubMed  Google Scholar 

  • Lee B, Park J, Park J, Shin HJ, Kwon S et al (2011) Cordyceps militaris improves neurite outgrowth in Neuro2a cells and reverses memory impairment in rats. Food Sci Biotechnol 20(6):1599–1608

    Article  CAS  Google Scholar 

  • Li QZ, Zheng YZ, Zhou XW (2019) Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms. Drug Discov Today 24(1):307–314. https://doi.org/10.1016/j.drudis.2018.09.014

    Article  CAS  PubMed  Google Scholar 

  • Li JP, Lee YP, Ma JC, Liu BR, Hsieh NT, Chen DC, Chu CL, You RI (2021) The enhancing effect of fungal immunomodulatory protein-Volvariella volvacea (FIP-vvo) on maturation and function of mouse dendritic cells. Life 11(6):471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liao CH, Hsiao YM, Lin CH, Yeh CS, Wang JCH, Ni CH et al (2008) Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae. Food Chem Toxicol 46:1851–1859

    Article  CAS  PubMed  Google Scholar 

  • Lin JY, Chou TB (1984) Isolation and characterization of a lectin from edible mushroom, Volvariella volvacea. J Biol Chem 96:35–40

    CAS  Google Scholar 

  • Lin SB, Li CH, Lee SS, Kan LS (2003) Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 72:2381–2390

    Article  CAS  PubMed  Google Scholar 

  • Lin CH, Hsiao YM, Ou CC, Lin YW et al (2010) GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor a-induced expression of matrix metalloproteinase 9 via NF-kB pathway in human alveolar epithelial A549 cells. J Agric Food Chem 58:12014–12021

    Article  CAS  PubMed  Google Scholar 

  • Ling-Sing Seow S, Naidu M, David P, Wong KH, Sabaratnam V (2013) Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells. BMC Complement Alternat Med 13:157

    Article  Google Scholar 

  • Liu D, Zheng H, Liu Z, Yang B, Tu W, Li L (2009) Chemical composition and antimicrobial activity of essential oil isolated from the culture mycelia of Ganoderma japonicum. J Nanjing Med Univ 23(3):168–172

    Article  CAS  Google Scholar 

  • Liu Y, Bastiaan-Net S, Wichers HJ (2020) Current understanding of the structure and function of fungal immunomodulatory proteins. Front Nutr 7:132

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Loganathan KJ, Kaviyarasan V, Gopalswamy S, Sherief AK (2009) Antioxidant and antiviral properties of Agaricus heterocystis Heinem. and Gooss. In: Proceedings of the 5th international medicinal mushroom conference. Mycological Society of China, Nantong, pp 173–182

    Google Scholar 

  • Loganathan KJ, Gunasundari D, Hemalatha M, Shenbhagaraman R, Kaviyarasan V (2010) Antioxidant and phytochemical potential of wild edible mushroom Termitomyces reticulatus: individual cap and stipe collected from South Eastern Part of India. Int J Pharm Sci 1(7):62–72

    Google Scholar 

  • Longvah T, Deosthale YG (1998) Composition and nutritional studies on edible wild mushroom from northeast India. Food Chem 63:331–334

    Article  CAS  Google Scholar 

  • Luisa CM, Jorge JC, Van’t Hof R, Cruz ME, Crommelin DJ, Storm G (2002) Superoxide dismutase entrapped in long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis. Biochim Biophys Acta 1564:227–236

    Article  Google Scholar 

  • Luo D, Xie YF, Tan ZL, Li XD (2013) Removal of Cu2+ ions from aqueous solution by the abandoned mushroom compost of Flammulina velutipes. J Environ Biol 34(2):359–365

    CAS  PubMed  Google Scholar 

  • Ma BJ, Ren W, Zhou Y, Ma JC, Ruan Y, Wen CN (2011a) Triterpenoids from the spores of Ganoderma lucidum. North Am J Med Sci 3:495–498

    Article  Google Scholar 

  • Ma L, Chen H, Zhu W, Wang Z (2011b) Effect of different drying methods on physicochemical properties and antioxidant activities of polysaccharides extracted from mushroom Inonotus obliquus. Food Res Int 50:633–640

    Article  Google Scholar 

  • Madan M, Bisaria R (1984) Cellulolytic enzymes produced by the edible mushroom, Pleurotus sajor-caju. Appl Biochem Biotechnol 9:397–398

    Article  Google Scholar 

  • Maggioni A, Passera C, Renosto F, Benetti E (1968) Composition of cultivated mushrooms (Agaricus bisporus) during the growing cycle as affected by the nitrogen source introduced in composting. J Agric Food Chem 16(3):517–519

    Article  CAS  Google Scholar 

  • Malinowska E, Krzyczkowski W, Herold F et al (2009) Biosynthesis of selenium-containing polysaccharides with antioxidant activity in liquid culture of Hericium erinaceum. Enzyme Microb Technol 44:334–343

    Article  CAS  Google Scholar 

  • Manole A, Herea D, Chiriac H, Melnig V (2008) Laccase activity determination. Scientific Annals of “ALEXANDRU IOAN CUZA DIN IAŞI” University. Tomul I, S. Biomaterials in Biophysics Medical Physics and Ecology, pp 17–24

    Google Scholar 

  • Mansur M, Arias ME, Copa-Patino JL, Flardh M, Gonzalez AE (2003) The white-rot fungus Pleurotus ostreatus secretes laccase isozymes with different substrate specificities. Mycologia 95(6):1013–1020

    Article  CAS  PubMed  Google Scholar 

  • Manzi P, Pizzoferrato L (2000) Beta-glucans in edible mushrooms. Food Chem 68:315–318

    Article  CAS  Google Scholar 

  • Marcotullio MC, Pagiott R, Maltese F, Obara Y, Hoshino T, Nakahata N, Curini M (2006) Neurite outgrowth activity of cyathane diterpenes from Sarcodoncyrneus, cyrneines A and B. Planta Med 72:819–823

    Article  CAS  PubMed  Google Scholar 

  • Marcotullio MC, Pagiott R, Maltese F, Oball-Mond Mwankie GN, Hoshino T, Obara Y, Nakahata N (2007) Cyathane diterpenes from Sarcodoncyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production. Bioorg Med Chem 15:2878–2882

    Article  CAS  PubMed  Google Scholar 

  • Martin KR, Pence JC, Bloomer RJ (2020) Vitamin D2-enhanced mushrooms as dietary supplements and nutraceuticals: a nutritionally sensible trade-off for the consumer. Clin J Nutr Diet 3(1)

    Google Scholar 

  • Matheny PB, Bougher NL (2006a) The new genus Auritella from Africa and Australia (Inocybaceae, Agaricales): molecular systematics, taxonomy and historical biogeography. Mycol Prog 5:2–17

    Article  Google Scholar 

  • Matheny PB, Bougher NL (2006b) Validation of the genus Auritella. Mycotaxon 97:231–233

    Google Scholar 

  • Mattila P, Piironen V, Uusi-Rauva E, Koivistoinen P (1994) Vitamin D contents in edible mushrooms. J Agric Food Chem 42:2449–2453

    Article  CAS  Google Scholar 

  • Mattila P, Konko K, Eurola M, Pihlava JM et al (2001) Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. J Agric Food Chem 49(5):2343–2348

    Article  CAS  PubMed  Google Scholar 

  • Mattila P, Lampi AM, Ronkainen R, Toivo J, Piironen V (2002) Sterol and vitamin D2 contents in some wild and cultivated mushrooms. Food Chem 76:293–298

    Article  CAS  Google Scholar 

  • Mau JL, Chen PR, Yang JH (1998) Ultraviolet irradiation increased Vitamin D2 content in edible mushrooms. J Agric Food Chem 46:5269–5272

    Article  CAS  Google Scholar 

  • Mau JL, Chang CN, Huang SJ, Chen CC (2004) Antioxidant properties of methanolic extracts from Grifola frondosa, Morchella esculenta and Termitomyces albuminosus mycelia. Food Chem 87:111–118

    Article  CAS  Google Scholar 

  • Mayer AM, Staples RC (2002) Laccase: new functions for an old enzyme. Phytochemistry 60(6):551–565

    Article  CAS  PubMed  Google Scholar 

  • Mcgowan DP, Van Roon-Mom W, Holloway H, Bates GP et al (2000) Amyloid-like inclusions in Huntington’s disease. Letter to Neuroscience. Neuroscience 100(4):677–680

    Article  CAS  PubMed  Google Scholar 

  • Metreveli E, Kachlishvili E, Singer SW, Elisashvili V (2017) Alteration of white-rot basidiomycetes cellulase and xylanase activities in the submerged co-cultivation and optimization of enzyme production by Irpexlacteus and Schizophyllum commune. Bioresour Technol 241:652–660

    Article  CAS  PubMed  Google Scholar 

  • Miller HE, Rigelhof F, Marquart L, Prakash A, Kanter M (2000) J Am Coll Nutr 19(3):312S–319S

    Article  CAS  PubMed  Google Scholar 

  • Min BS, Gao J, Nakamura N, Hattori M (2000) Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against Meth-A and LLC tumor cells. Chem Pharm Bull 48:1026–1033

    Article  CAS  Google Scholar 

  • Min BS, Gao JJ, Hattori M, Lee HK, Kim YH (2001) Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med 67(9):811–814

    Article  CAS  PubMed  Google Scholar 

  • Mizuno T, Saito H, Nishitoba T, Kawagishi H (1995) Antitumor active substances from mushrooms. Food Rev Int 11:23–61

    Article  CAS  Google Scholar 

  • Moore BM, Flurkey WH (1989) A research note—Tyrosinase activities and isoenzymes in three strains of mushroom. J Food Sci 54(5):1377–1378

    Article  CAS  Google Scholar 

  • Moore BM, Kang B, Flurkey WH (1988) Histochemical and immunochemical localization of tyrosinase in whole tissue sections of mushrooms. Phytochemistry 27(12):3735–3737

    Article  CAS  Google Scholar 

  • More SS, Renuka PS, Pruthvi K, Swetha M, Malini S, Veena SM (2011) Isolation, purification, and characterization of fungal laccase from Pleurotus sp. Enzyme Res 2011:248735

    Article  PubMed  PubMed Central  Google Scholar 

  • Morigiwa A, Kitabatake K, Fujimoto Y, Ikekawa N (1986) Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem Pharm Bull 34:3025–3028

    Article  CAS  Google Scholar 

  • Mothana RAA, Jansen R, Julich WD, Lindequist U (2000) Ganomycin A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi. J Nat Prod 63:416–418

    Article  CAS  PubMed  Google Scholar 

  • Mridu C, Atri NS (2017) Nutritional and nutraceutical characterization of three wild edible mushrooms from Haryana, India. Mycosphere 8:1035–1043

    Article  Google Scholar 

  • Mtibaa R, Barriuso J, Eugenio LD, Aranda E et al (2018) Purification and characterization of a fungal laccase from the ascomycete Thielavia sp. and its role in the decolorization of a recalcitrant dye. Int J Biol Macromol 120:1744–1751

    Article  CAS  PubMed  Google Scholar 

  • Munjal RL (1974) Mushroom for every home. University Publication, Chennai

    Google Scholar 

  • Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H (2006) Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem 17:525–530

    Article  CAS  PubMed  Google Scholar 

  • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yanker BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765):98–103

    Article  CAS  PubMed  Google Scholar 

  • Natarajan K, Manjula B (1978) Studies on Lentinus squarrosulus Lev. In: Atal CK, Bhatt BK, Kaul TN (eds) Indian mushroom science. Indo-American Literature House, New Delhi, pp 451–456

    Google Scholar 

  • Ngai PH, Ng TB (2004) A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju. Peptides 25(1):11–17

    Article  CAS  PubMed  Google Scholar 

  • Nikitina VE, Loshchinina EA, Vetchinkina EP (2017) Lectins from mycelia of basidiomycetes. Int J Mol Sci 18:e1334

    Article  Google Scholar 

  • Niku-Paavola ML, Karhunen E, Salola P, Raunio V (1988) Ligninolytic enzymes of the white-rot fungus Phlebia radiata. Biochem J 254:877–884

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Niku-Paavola ML, Raaska L, Itavaara M (1990) Detection of white-rot fungi by a non-toxic stain. Mycol Res 94(1):27–31

    Article  Google Scholar 

  • Ning YJ, Wang SS, Chen QJ, Ling ZR, Wang SN et al (2016) An extracellular yellow laccase with potent dye decolorizing ability from the fungus Leucoagaricus naucinus LAC-04. Int J Biol Macromol 93:837–842

    Article  CAS  PubMed  Google Scholar 

  • Nitschke J, Modick H, Busch E, Rekowski RWV et al (2011) A new colorimetric method to quantify β-1,3-1,6-glucans in comparison with total β-1,3-glucans in edible mushrooms. Food Chem 127:791–796

    Article  CAS  PubMed  Google Scholar 

  • Obara Y, Nakahata N, Kita T, Takaya Y et al (1999) Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. Eur J Pharmacol 370:79–84

    Article  CAS  PubMed  Google Scholar 

  • Ooi VEC, Liu F (2000) Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem 7:715–729

    Article  CAS  PubMed  Google Scholar 

  • Osono T, Takeda H (2002) Comparison of litter decomposing ability among diverse fungi in a cool temperate deciduous forest in Japan. Mycologia 94:421–427

    Article  CAS  PubMed  Google Scholar 

  • Oyetayo OV (2011) Medicinal uses of mushrooms in Nigeria: towards full and sustainable exploitation. Afr J Tradit Complement Alternat Med 8(3):267–274

    Google Scholar 

  • Oyetayo VO, Ariyo OO (2013) Antimicrobial and antioxidant properties of Pleurotus ostreatus (Jacq: Fries) cultivated on different tropical woody substrates. J Waste Convers Bioprod Biotechnol 1(2):28–32

    Google Scholar 

  • Pandey M, Satish GC, Shamina A, Gowda NKS, Chandrashekara C (2020a) Mushroom for nutrition and environment sensitive agriculture. Technical bulletin No 06/2020. ICAR-IIHR, Hesaraghatta Bengaluru

    Google Scholar 

  • Pandey M, Gowda NKS, Satish GC, Shamina A, Chandrashekara C, Zamil M, Roy T (2020b) Studies on bioavailability of iron from non-fortified and iron-fortified commercial edible mushroom Hypsizygus ulmarius and standardization of its delivery system to human nutrition. J Hortic Sci 15(2):197–206

    Article  Google Scholar 

  • Panov AV, Burke JR, Strittmatter WJ, Greenamyre JT (2003) In vitro effects of polyglutamine tracts on Ca2+ dependent depolarization of rat and human mitochondria: relevance to Huntington’s disease. Arch Biochem Biophys 410:1–6

    Article  CAS  PubMed  Google Scholar 

  • Pardo I, Chanaga X, Vicente AI, Alcalde M, Camarero S (2013) New colorimetric screening assays for the directed evolution of fungal laccases to improve the conversion of plant biomass. BMC Biotechnol 13(90):1–14

    Google Scholar 

  • Park YS, Lee HS, Won MH, Lee JH, Lee SY, Lee HY (2002) Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells. Cytotechnology 39:155–162

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Park HG, Shim YY, Choi SO, Park WM (2009) New method development For nanoparticle extraction of water-soluble β-(1→3)-D-Glucan from edible mushrooms, Sparassis crispa and Phellinus linteus. J Agric Food Chem 57:2147–2154

    Article  CAS  PubMed  Google Scholar 

  • Pathania P, Sagar A (2014) Studies on the biology of Cordyceps militaris: a medicinal mushroom from northwest Himalaya. Kavaka 43:35–40

    Google Scholar 

  • Perutz MF (1996) Glutamine repeats and inherited neurodegenerative diseases: molecular aspects. Curr Opin Cell Biol 6:848–858

    CAS  Google Scholar 

  • Petrova RD (2012) New scientific approaches to cancer treatment: can medicinal mushrooms defeat the curse of the century? Int J Med Mushrooms 14:1–20

    Article  CAS  PubMed  Google Scholar 

  • Phan CW, Wong WL, David P, Naidu M, Sabaratnam V (2012) Pleurotus giganteus (Berk.) Karunarathna and K.D. Hyde: nutritional value and in vitro neurite outgrowth activity rat pheochromocytoma cells. BMC Complement Altern Med 12:102

    Article  PubMed  PubMed Central  Google Scholar 

  • Pillai TG, John M, Thomas GS (2011) Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in Southern Parts of India. Exp Toxicol Pathol 63(1–2):157–160

    Article  CAS  PubMed  Google Scholar 

  • Pohleven J, Kos J, Sabotic J (2016) Medicinal properties of the genus Clitocybe and of lectins from the Clouded Funnel Cap mushroom, C. nebularis (Agaricomycetes): a review. Int J Med Mushrooms 18(11):965–975

    Article  PubMed  Google Scholar 

  • Prasad Y, Wesely WEG (2008) Antibacterial activity of the bio-multidrug (Ganoderma lucidum) on multidrug resistant Staphylococcus aureus (MRSA). Adv Biotechnol 10:9–16

    Google Scholar 

  • Prasad N, Ramteke P, Dholia N, Yadav UCS (2018) Therapeutic interventions to block oxidative stress-associated pathologies. In: Immunity and inflammation in health and disease. Academic, New York, pp 341–362

    Chapter  Google Scholar 

  • Preuss HG, Echard B, Bagchi D, Perricone NV, Zhuang C (2007) Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol Cell Biochem 306(1–2):105–113

    Article  CAS  PubMed  Google Scholar 

  • Purkayastha RP, Chandra A (1985) Manual of Indian edible mushrooms. Today and Tomorrows Printers and Publishers, New Delhi

    Google Scholar 

  • Pushpa H, Purushothama KB (2012) Biodiversity of mushrooms in and around Bangalore, Karnataka, India. Am Eurasian J Agric Environ Sci 12(6):75–79

    Google Scholar 

  • Puttaraju NG, Venkateshaiah SU, Dharmesh SM, Nanjaraj Urs SM, Somasundaram R (2006) Antioxidant activity of indigenous edible mushrooms. J Agric Food Chem 54(26):9764–9772

    Article  CAS  PubMed  Google Scholar 

  • Qi J, Ojika M, Sakagami Y (2000) Termitomycesphins A–D, novel neuritogenic cerebrosides from the edible Chinese mushroom Termitomyces albuminosus. Tetrahedron 56(32):5835–5841

    Article  CAS  Google Scholar 

  • Qi J, Ojika M, Sakagami Y (2001) Neuritogenic cerebrosides from an edible Chinese mushroom. Part 2: structures of two additional termitomycesphins and activity enhancement of an inactive cerebroside by hydroxylation. Bioorg Med Chem 9(8):2171–2177

    Article  CAS  PubMed  Google Scholar 

  • Quereshi S, Pandey AK, Sandhu SS (2010) Evaluation of antibacterial activity of different Ganoderma lucidum extracts. People’s J Sci Res 3:9–14

    Google Scholar 

  • Radzki W, Slawinska A, Jablonska-Rys E, Gustaw W (2014) Antioxidant capacity and polyphenolic content of dried wild edible mushrooms from Poland. Int J Med Mushrooms 16(1):65–75

    Article  PubMed  Google Scholar 

  • Ramesh C, Pattar MG (2010) Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of Western Ghats of Karnataka, India. Pharmcognosy Res 2(2):107–112

    Article  CAS  Google Scholar 

  • Rao JR, Millar BC, Moore JE (2009) Letter to the Editor: Antimicrobial properties of shitake mushrooms (Lentinula edodes). Int J Antimicrob Agents 33:591–592

    Article  CAS  PubMed  Google Scholar 

  • Reis FS, Pereira E, Barros L, Sousa MJ, Martins A, Ferreira ICFR (2011) Biomolecule profiles in inedible wild mushrooms with antioxidant value. Molecules 16:4328–4338

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Reis FS, Barros L, Martins A, Ferreira ICFR (2012) Chemical composition and nutritional value of the most widely appreciated cultivated mushrooms: an inter-species comparative study. Food Chem Toxicol 50:191–197

    Article  CAS  PubMed  Google Scholar 

  • Rhee SJ, Cho SY, Kim KM, Cha D, Park H (2008) Comparative study of analytical methods for alkali-soluble β-glucan in medicinal mushroom, Chaga (Inonotus obliquus). LWT 41:545–549

    Article  CAS  Google Scholar 

  • Rodriguez CS, Herrera JLT (2006) Industrial and biotechnological applications of laccases: a review. Biotechnol Adv 24(5):500–513

    Article  Google Scholar 

  • Sabaratnam V, Phan CW (2018) Neuroactive components of culinary and medicinal mushrooms with potential to mitigate age-related neurodegenerative diseases. In: Discovery and development of neuroprotective agents from natural products. Elsevier, Amsterdam, pp 401–413

    Chapter  Google Scholar 

  • Sai (2021) Investigations on biochemical and biological aspects of two wild edible mushrooms of Anantapur (A.P.). Ph.D. thesis. Sri Sathya Sai Institute of Higher Learning

    Google Scholar 

  • Sai I, Basavaraju R (2020a) Antioxidant properties of two wild edible mushrooms from Andhra Pradesh. Kavaka 54:107–114

    Article  Google Scholar 

  • Sai I, Basavaraju R (2020b) Nutritional composition and antimicrobial activity of two wild edible mushrooms from Andhra Pradesh. Res J Agric Sci 11(6):1388–1394

    Google Scholar 

  • Sai I, Basavaraju R (2021) Isolation and quantification of biotechnologically important enzymes from Podaxis pistillaris and Termitomyces heimii from Andhra Pradesh. Kavaka 56:98–104

    Google Scholar 

  • Saito K, Ikeda R, Endo K, Tsujino Y, Takagi M, Tamiya E (2012) Isolation of a novel alkaline-induced laccase from Flammulina velutipes and its application for hair coloring. J Biosci Bioeng 113(5):575–579

    Article  CAS  Google Scholar 

  • Salemi S, Saedisomeolia A, Azimi F, Zolfigol S, Mohajerani E, Mohammadi M, Yaseri M (2021) Optimizing the production of vitamin D in white button mushrooms (Agaricus bisporus) using ultraviolet radiation and measurement of its stability. LWT 137:110401

    Article  CAS  Google Scholar 

  • Salinaro AT, Pennisi M, Di Paola R, Scuto M, Crupi R et al (2018) Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms. Immun Ageing 15:8

    Article  Google Scholar 

  • Sandhya S, Vinod KR, Kumar S (2010) Herbs used for brain disorders. Hygeia J Drugs Med 2:38–45

    Google Scholar 

  • Sasidharan S, Aravindran S, Lachimanan YL, Ratnasamy V, Saravanan D, Santhanam A (2010) In vitro antioxidant activity and hepatoprotective effects of Lentinula edodes against paracetamol-induced hepatotoxicity. Molecules 15:4478–4489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Scheunert A, Schieblich M, Reschke J (1935) About the vitamin D contents in some edible mushrooms. Hoppe-Seylers Z Physiol Chem 235:91–95

    Article  CAS  Google Scholar 

  • Semedo MC, Karmali A, Fonseca L (2015) A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye. J Microbiol Methods 109:140–148

    Article  CAS  PubMed  Google Scholar 

  • Seo SY, Sharma VK, Sharma N (2003) Mushroom tyrosinase: recent prospects. J Agric Food Chem 51:2837–2853

    Article  CAS  PubMed  Google Scholar 

  • Sethi V, Anand JC (1978) Processing of mushrooms. Ind Mush Sci 1:235–238

    Google Scholar 

  • Sharma SK, Atri NS, Thakur R, Gulati A (2014) Taxonomy and compositional analysis of two new for science medicinal mushroom taxa from India. Int J Med Mushrooms 16(6):593–603

    Article  PubMed  Google Scholar 

  • Sheena N, Ajith TA, Thomas M, Janardhanan KK (2003) Antibacterial activity of three macrofungi, Ganoderma lucidum, Navesporus floccose and Phellinus rimosus occurring in South India. Pharm Biol 41(8):564–567

    Article  Google Scholar 

  • Sheu F, Chien PJ, Hsieh KY, Chin KL, Huang WT, Tsao CY, Chen YF, Cheng HC, Chang HH (2009) Purification, cloning, and functional characterization of a novel immunomodulatory protein from Antroida camphorate (Bitter mushroom) that exhibits TLR2- dependent NF-kB activation and M1 polarization within murine macrophages. J Agric Food Chem 57:4130–4141

    Article  CAS  PubMed  Google Scholar 

  • Shi XW, Liu L, Gao JM, Zhang AL (2011) Cyathane diterpenes from Chinese mushroom Sarcodon scabrosus and their neurite outgrowth-promoting activity. Eur J Med Chem 46(7):3112–3117

    Article  CAS  PubMed  Google Scholar 

  • Shiao MS, Lee KR, Lee JL, Cheng TW (1994) Natural products and biological activities of the Chinese medicinal fungus. In: ACS Symp. ser. 547. Food phytochemicals for cancer prevention II. American Chemical Society, Washington, DC, pp 342–354

    Chapter  Google Scholar 

  • Singer R (1961) Mushrooms and truffles. Interscience Publishers, London, p 272

    Google Scholar 

  • Singer R (1986) The agaricales in modern taxonomy, 4th edn. Koeltz Scientific Books, Koenigstein

    Google Scholar 

  • Singh Y, Kaur M (2016) Two species of genus Amanita from India. World J Pharm Pharm Sci 5(5):1054–1062

    CAS  Google Scholar 

  • Singh AD, Abdullah N, Vikineswary S (2003) Optimization of extraction of bulk enzymes from spent mushroom compost. J Chem Technol Biotechnol 78:743–752

    Article  CAS  Google Scholar 

  • Singh RP, Verma RC, Arora RK, Mishra KK, Bhanu C, Singh M (2007) Medicinal mushrooms of Uttaranchal with reference to Ganoderma, Auricularia and Cordyceps sinensis. In: Rai RD, Singh SK, Yadav MC, Tewari RP (eds) Mushroom biology and biotechnology. Mushroom Society of India, NRCM Chambaghat, Solan, pp 321–324

    Google Scholar 

  • Singh RS, Walia AK, Kennedy JF (2019) Mushroom lectins in biomedical research and development. Int J Biol Macromol 151:1340–1350

    Article  PubMed  Google Scholar 

  • Sivakumar R, Vetrichelvan T, Rajendran NN, Devi MI, Sundaramoorthi K, Shankar ASK, Shanmugam S (2006) Antibacterial activity of mushroom Osmoporus odoratus. Indian J Pharm Sci 68(4):523–524

    Article  Google Scholar 

  • Smania A Jr, Monache FD, Smania EFA, Cuneo RS (1999) Antibacterial activity of steroidal compounds isolated from Ganoderma applanatum(Pers.) Pat.(Aphyllophoromycetideae) fruit body. Int J Med Mushrooms 1:325–330

    Article  Google Scholar 

  • Solomko EF, Eliseeva GS (1988) Biosynthesis of vitamins B by the fungus Pleurotus ostreatus in a submerged culture. Prikl Biokhim Mikrobiol 24(2):164–169

    CAS  PubMed  Google Scholar 

  • Sonawane H, Ghole V, Garad S, Bapat G, Bhosle S, Apte K (2013) Hypoglycemic effect of Phansomba (Phellinus badius Berk Ex Cooke) G. Cunn. on alloxan-induced diabetic rats. J Nat Remedies 13:29–34

    Google Scholar 

  • Sornlake W, Rattanaphanjak P, Champreda V, Eurwilaichitr L et al (2017) Characterization of cellulolytic enzyme system of Schizophyllum commune mutant and evaluation of its efficiency on biomass hydrolysis. Biosci Biotechnol Biochem 81(7):1289–1299

    Article  CAS  PubMed  Google Scholar 

  • Srinivasan C, D’souza TM, Boominathan K, Reddy CA (1995) Demonstration of Laccase in the White Rot Basidiomycete Phanerochaete chrysosporium BKM-F1767. Appl Environ Microbiol 16(12):4274–4277

    Article  Google Scholar 

  • Stadler M, Anke H, Stener O (1994) New nematicidal and antimicrobial compounds from the basidiomycete Cheimonophyllum candidissimum (Berk and Curt) Sing. J Antibiot (Tokyo) 47:1284–1289

    Article  CAS  PubMed  Google Scholar 

  • Steffen K, Hofrichter M, Hatakka A (2000) Mineralization of 14C-labelledsynthetic lignin and ligninolytic enzyme activities of litter-decomposing basidiomycetous fungi. Appl Microbiol Biotechnol 54:819–825

    Article  CAS  PubMed  Google Scholar 

  • Sullivan R, Smith JE, Rowan NJ (2006) Medicinal mushrooms and cancer therapy—translating a traditional practice into Western medicine. Perspect Biol Med 49:159–170

    Article  CAS  PubMed  Google Scholar 

  • Susmitha S, Vidyamol KK, Ranganayaki P, Vijayaraghavan R (2014) Purification of catalase enzyme from Pleurotus ostreatus. Int J Appl Biol Pharm Technol 5(1):28–34

    CAS  Google Scholar 

  • Sutherland C, Venkobachar C (2013) Equilibrium modeling of Cu (II) biosorption onto untreated and treated forest macro-fungus Fomes fasciatus. Int J Plant Anim Environ Sci 4:193–203

    Google Scholar 

  • Svajger U, Pohleven J, Kos J, Strukelj B, Jeras M (2011) CNL, a ricin B-like lectin from mushroom Clitocybe nebularis, induces maturation and activation of dendritic cells via the toll-like receptor 4 pathway. Immunology 134:409–418

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Synytsya A, Mickova K, Synytsya A, Jablonsky I, Speacek J, Erban V, Kovarikova E, Copikova J (2009) Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: structure and potential prebiotic activity. Carbohydr Polym 76:548–556

    Article  CAS  Google Scholar 

  • Sze SCW, Ho JCK, Liu WK (2004) Volvariella volvacea lectin activates mouse T lymphocytes by a calcium dependent pathway. J Cell Biochem 92(6):1193–1202

    Article  CAS  PubMed  Google Scholar 

  • Tanaka S, Ko K, Kino K, Tsuchiya K et al (1989) Complete amino acid sequence of an immunomodulatory protein, ling-zhi-8 (LZ-8) an immunomodulator from a fungus Ganoderma lucidum, having similarity to immunoglobulin variable regions. J Biol Chem 464:16372–16377

    Article  Google Scholar 

  • Tang YJ, Zhong JJ (2002) Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus Ganoderma lucidum, grown on lactose in a bioreactor. Biotechnol Lett 24:1023–1026

    Article  CAS  Google Scholar 

  • Thakur M, Lakhanpal TN (2014) Qualitative phytochemical screening, total phenolic content and in-vitro antioxidant activity in methanolic extracts of Morchella esculenta Fr. In: Proceedings of the 8th international conference on mushroom biology and mushroom products, pp 215–220

    Google Scholar 

  • Thakur M, Sayeed R (2014) Qualitative phytochemical screening, total phenolic content, in-vitro antioxidant activity and antimicrobial activities in methanolic extracts of Lactarius sanguifluus (Paulet) Fr. J Pure Appl Microbiol 8(6):4735–4741

    Google Scholar 

  • Thakur M, Shah R (2016) Phytochemical screening, in-vitro antioxidant and antimicrobial potential in the methanolic extracts of Russula brevipes Peck. and Sparassis crispa Fr. J Basic Appl Mycol 12:111–117

    Google Scholar 

  • Thakur A, Rana M, Lakhanpal TN, Ahmad A, Khan MI (2007a) Purification and characterization of lectin from fruiting body of Ganoderma lucidum lectin from Ganoderma lucidum. Biochim Biophys Acta 1770:1404–1412

    Article  CAS  PubMed  Google Scholar 

  • Thakur A, Lakhanpal TN, Ahmad A, Khan MI (2007b) Complex carbohydrate specificity of lectin from fruiting body of Ganoderma lucidum. A surface plasmon resonance study. IUBMB Life 59(12):758–764

    Article  CAS  PubMed  Google Scholar 

  • The Huntington’s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72:971–983

    Article  Google Scholar 

  • Thetsrimuang C, Khammuang S, Chiablaem K, Srisomsap C, Sarnthima R (2011) Antioxidant properties and cytotoxicity of crude polysaccharides from Lentinus polychrous Lév. Food Chem 128:634–639

    Article  CAS  Google Scholar 

  • Thurston CF (1994) The structure and function of fungal laccases. Microbiology 140:19–26

    Article  CAS  Google Scholar 

  • Tokimoto K, Fukuda M, Matsumoto T, Fukumasa-Nakai Y (1998) Variation of fruiting body productivity in protoplast fusants between compatible monokaryons of Lentinula edodes. J Wood Sci 44:469–472

    Article  CAS  Google Scholar 

  • Trovato A, Siracusa R, Di Paola R, Scuto M et al (2016) Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: relevance to Alzheimer’s disease pathogenesis. Neurotoxicology 53:350–358

    Article  CAS  PubMed  Google Scholar 

  • Tsai SY, Huang SJ, Mau JL (2006) Antioxidant properties of hot-water extracts from Agrocybe cylindracea. Food Chem 98:670–677

    Article  CAS  Google Scholar 

  • Valverde ME, Hernandez-Perez T, Paredes-Lopez O (2015) Edible mushrooms: improving human health and promoting quality life. Int J Microbiol 14:376387

    Google Scholar 

  • van der Hem LG, van der Vliet JA, Kino K, Hoitsma AJ, Tax WJ (1996) Ling Zhi-8: a fungal protein with immunomodulatory effects. Transplant Proc 28:958–959

    PubMed  Google Scholar 

  • Varrot A, Basheer SM, Imberty A (2013) Fungal lectins: structure, function and potential applications. Curr Opin Struct Biol 23:678–685

    Article  CAS  PubMed  Google Scholar 

  • Vaz JA, Barros L, Martins A, Santo-Buelga C, Vasconcelos MH, Ferreira ICFR (2011) Chemical composition of wild edible mushrooms and antioxidant properties of their water soluble polysaccharidic and ethanolic fractions. Food Chem 126:610–616

    Article  CAS  Google Scholar 

  • Villares A, García-Lafuente A, Guillamón E, Ramos A (2012) Identification and quantification of ergosterol and phenolic compounds occurring in Tuber spp. truffles. J Food Compost Anal 26:177–182

    Article  CAS  Google Scholar 

  • Virk AP, Sharma P, Capalash N (2012) Use of laccase in pulp and paper industry. Biotechnol Program 28:21–32

    Article  CAS  Google Scholar 

  • Viswanath B, Rajesh B, Janardhan A, Kumar AP, Narasimha G (2014) Fungal laccases and their applications in bioremediation. Enzyme Res 2014:163242

    Article  PubMed  PubMed Central  Google Scholar 

  • Wada S, Ichikawa H, Tatsumi K (1993) Removal of phenols and aromatic amines from wastewater by soluble and immobilized tyrosinase. Biotechnol Bioeng 42:854–858

    Article  CAS  PubMed  Google Scholar 

  • Wagner R, Mitchell DA, Sassaki GL, Amazonas MAL, Berovi M (2003) Current techniques for the cultivation of Ganoderma lucidum for the production of biomass, ganoderic acid and polysaccharides. Food Technol Biotechnol 41:371–382

    CAS  Google Scholar 

  • Wahid MA, Sattar, Khan S (1988) Composition of wild and cultivated mushrooms of Pakistan. Mush J Tropics 8:47–51

    Google Scholar 

  • Waktola G, Temesgen T (2018) Application of mushroom as food and medicine. Adv Biotechnol Microbiol 11(3):555817

    Google Scholar 

  • Wang L, Yue L, Xiaoxian Y (1991) Analysis of amino acid content of thirty varieties of edible fungi. Mushroom J Tropics 10:74–78

    Google Scholar 

  • Wang HX, Ng TB, Ooi VEC, Liu WK, Chang ST (1997) Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-spanin sarcoma-bearing mice. Anticancer Res 17:416–420

    CAS  Google Scholar 

  • Wang PH, Hsu CI, Tang SC, Huang YL et al (2004) Immunomodulatory protein from Flammulina velutipes induces interferon-g-production through p38 mitogen-activated protein kinase signaling pathway. Agric Food Chem 52:2721–2725

    Article  CAS  Google Scholar 

  • Wang XF, Li QZ, Bao TW, Cong WR, Song WX, Zhou XW (2013) In vitro rapid evolution of fungal immunomodulatory proteins by DNA family shuffling. Appl Microbiol Biotechnol 97:2455–2465

    Article  CAS  PubMed  Google Scholar 

  • Wasser SP (2010) Medicinal mushroom science: history, current status, future trends, and unsolved problems. Int J Med Mushrooms 12:1–16

    Article  CAS  Google Scholar 

  • Wasser SP, Weis AL (1999a) Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 19:65–96

    CAS  PubMed  Google Scholar 

  • Wasser SP, Weis AL (1999b) Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspectives (Review). Int J Med Mushrooms 1:31–62

    Article  CAS  Google Scholar 

  • Wasser SP, Weis AL, Nevo E (1997) Medicinal mushrooms: Ganoderma lucidum (Curtis: Fr.) P. Karst. Reishi Mushroom. Pedelfus Publishing House, Haifa

    Google Scholar 

  • Weaver JC, Kroger M, Kneebone LR (1977) Comparative protein studies (Kjeldahl, dye binding, amino acid analysis) of nine strains of Agaricus bisporus (Lange) Imbach mushrooms. J Food Sci 42:364–366

    Article  CAS  Google Scholar 

  • Wichers HJ, Gerritsen YAM, Chapelon CGJ (1996) Tyrosinase isoforms from the fruit bodies of Agaricus bisporus. Phytochemistry 43(2):333–337

    Article  CAS  Google Scholar 

  • Willis KJ (ed) (2018) State of the world’s fungi 2018. Report. Royal Botanic Gardens, Kew

    Google Scholar 

  • Wood DA (1980) Production, purification and properties of extracellular laccase of Agaricus bisporus. J Gen Microbiol 117:327–338

    CAS  Google Scholar 

  • Xia F, Fan J, Zhu M, Tong H (2010) Antioxidant effects of a water-soluble proteoglycan isolated from the fruiting bodies of Pleurotus ostreatus. J Taiwan Inst Chem Eng 42(3):402–407

    Article  Google Scholar 

  • Xie C, Yan L, Gong W, Zhu Z, Tan S, Chen D et al (2016) Effects of different substrates on lignocellulosic enzyme expression, enzyme activity, substrate utilization and biological efficiency of Pleurotus eryngii. Cell Physiol Biochem 39:1479–1494

    Article  CAS  PubMed  Google Scholar 

  • Xu W, Liu L, Charles IG, Moncada S (2004) Nitric oxide induces coupling of mitochondrial signaling with the endoplasmic reticulum stress response. Nat Cell Biol 6(11):1129–1134

    Article  CAS  PubMed  Google Scholar 

  • Xue WJ, Yang W, Chen QH (1989) Prevention and treatment of alloxan-induced diabetes in mice by the polysaccharides from Laminaria japonica and Hericium erinaceus. J China Pharm Univ 20:378–380

    CAS  Google Scholar 

  • Yaltirak T, Aslim B, Ozturk S, Alli H (2009) Antimicrobial and antioxidant activities of Russula delica Fr. Food Chem Toxicol 47:2052–2056

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto K, Kimura T, Sugitachi A, Matsuura N (2009) Anti-angiogenic and anti-metastatic effects of β-1,3-D-glucan purified from Hanabiratake, Sparassis crispa. Biol Pharm Bull 32(2):259–263

    Article  CAS  PubMed  Google Scholar 

  • Yan JK, Li L, Wang ZM, Leung PH, Wang WQ, Wu JY (2009) Acidic degradation and enhance antioxidant activities of exopolysaccharides from Cordyceps sinensis mycelial culture. Food Chem 117:641–646

    Article  CAS  Google Scholar 

  • Yan PS, Cao LX, Zhang BZ (2014) Efficient purification of antiproliferative polysaccharides from Hypsizigus marmoreus with radial flow chromatography. Biotechnol Prog 30:872–878

    Article  CAS  PubMed  Google Scholar 

  • Yang BK, Gu YA, Jeong YT, Jeong H, Song CH (2007) Chemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process. Int J Biol Macromol 41(3):227–233

    Article  CAS  PubMed  Google Scholar 

  • Yang Y, Ye L, Zhang JS, Liu YF, Tang QJ (2009) Structural analysis of a bioactive polysaccharide, PISP1, from the medicinal mushroom Phellinus igniarius. Biosci Biotechnol Biochem 73(1):134–139

    Article  CAS  PubMed  Google Scholar 

  • Yang JP, Hsu T, Lin F, Hsu W, Chen Y (2012) Potential antidiabetic activity of extracellular polysaccharides in submerged fermentation culture of Coriolus versicolor LH1. Carbohydr Polym 90(1):174–180

    Article  CAS  PubMed  Google Scholar 

  • Ylostalo J, Srnastava K, Flurkey WH (2001) Characterization of a tyrosinase isoform from the cap skin of portabella mushrooms. J Food Biochem 25:493–507

    Article  CAS  Google Scholar 

  • Yuan Z, He P, Cui J, Takeuchi H (1998) Hypoglycemic effect of water-soluble polysaccharide from Auricularia auricula-judae Quel. on genetically diabetic KK-Ay mice. Biosci Biotechnol Biochem 62:1898–1903

    Article  CAS  PubMed  Google Scholar 

  • Zaidi KU, Ali AS (2015) Comparative evaluation of purified and characterized tyrosinase from two edible mushrooms, Agaricus bisporus and Pleurotus ostreatus and their clinical potential. Biosci Biotech Res Commun 8(2):161–170

    Google Scholar 

  • Zakia B (1978) The nutritive values of mushrooms. Ind Mush Sci 1:471–487

    Google Scholar 

  • Zhang M, An C, Gao Y, Leak RK, Chen J, Zhang F (2013) Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol 100:30–47

    Article  CAS  PubMed  Google Scholar 

  • Zhou XW, Chen WQ, Deng BW, Wang Z, Peng H, Lin J (2005) Application of biotechnology to exploitation and preservation of medicinal fungi. Chin Tradit Herb Drugs 36:451–455

    Google Scholar 

  • Zhu M, Chang Q, Wong LK, Chong FS, Li RC (1999) Triterpene antioxidants from Ganoderma lucidum. Phytother Res 13:529–531

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Isha Sai .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sai, I., Basavaraju, R., Thakur, M., Lakhanpal, T.N. (2023). Health Benefits of Mushrooms: An Appraisal. In: Singh, I., Rajpal, V.R., Navi, S.S. (eds) Fungal Resources for Sustainable Economy. Springer, Singapore. https://doi.org/10.1007/978-981-19-9103-5_7

Download citation

Publish with us

Policies and ethics