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Cocrystallization and Coamorphization for Druggability Enhancement of Chinese Medicines

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Novel Drug Delivery Systems for Chinese Medicines

Abstract

Cocrystallization and coamorphization techniques incorporating active ingredient of Chinese medicine and an or more appropriate coformer(s) into a homogeneous single-phase system have been employed as promising formulation strategies to improve the druggability (e.g., solubility, dissolution, stability, hygroscopicity, and tabletability, etc.) of Chinese medicines. Over the past decade, increasing reports have been published on investigations of cocrystal and coamorphous drug delivery systems of Chinese medicines. This chapter summarizes recent findings of cocrystallization and coamorphization for druggability improvement of Chinese medicines and provides their updates as a comprehensive overview in terms of definition and classification, preparation methods, druggability-related pharmaceutical properties, in vivo performances, and physicochemical characterizations.

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  1. Hao Cheng and Weili Heng contributed equally to this work.

Authors and Affiliations

  1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China

    Hao Cheng, Weili Heng, Jiawei Han, Yuanfeng Wei, Shuai Qian & Yuan Gao

  2. Department of Chemistry, Smith College, Northampton, MA, USA

    Linghe Zhang

  3. School of Pharmacy, China Pharmaceutical University, Nanjing, China

    Jianjun Zhang

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  1. Hao Cheng
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  1. Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Nianping Feng

  2. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong kong, China

    Zhijun Yang

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Cheng, H. et al. (2021). Cocrystallization and Coamorphization for Druggability Enhancement of Chinese Medicines. In: Feng, N., Yang, Z. (eds) Novel Drug Delivery Systems for Chinese Medicines. Springer, Singapore. https://doi.org/10.1007/978-981-16-3444-4_11

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