Abstract
Pathophysiological changes in obstructive sleep apnea (OSA) related to neural respiratory drive can be assessed by diaphragm EMG recorded from surface electrodes, in particular, esophageal electrode. Although esophageal pressure was considered to be the gold standard in assessment of respiratory effort, it can be influenced by changes in lung volume and airflow. Diaphragm EMG recorded from esophageal electrode has an advantage over esophageal pressure in assessment of neural respiratory drive in patients with obstructive sleep apnea whose airflow and lung volume are not stable during overnight sleep. In this chapter, the recording of diaphragm EMG from an esophageal electrode catheter is discussed. Application of diaphragm EMG has been used to further understand the mechanism of pathophysiological changes in patients with OSA including those with both OSA and chronic obstructive pulmonary disease (COPD), overlap syndrome. Assessment of diaphragm EMG can also be used to differentiate central from obstructive sleep apneas.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
American Thoracic Society/European Respiratory Society. ATS/ERS statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002;166(4):518–624.
Chaouat A, Weitzenblum E, Krieger J, Ifoundza T, Oswald M, Kessler R. Association of chronic obstructive pulmonary disease and sleep apnea syndrome. Am J Respir Crit Care Med. 1995;151(1):82–6.
Du W, Liu J, Zhou J, Ye D, OuYang Y, Deng Q. Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005–2008 National Health and Nutrition Examination Survey. Int J Chron Obstruct Pulmon Dis. 2018;13:665–74.
Gleeson K, Zwillich CW, White DP. The influence of increasing ventilatory effort on arousal from sleep. Am Rev Respir Dis. 1990;142(2):295–300.
He BT, Lu G, Xiao SC, Chen R, Steier J, Moxham J, et al. Coexistence of OSA may compensate for sleep related reduction in neural respiratory drive in patients with COPD. Thorax. 2017;72(3):256–62.
Kay A, Trinder J, Kim Y. Individual differences in relationship between upper airway resistance and ventilation during sleep onset. J Appl Physiol (1985). 1995;79(2):411–9.
Kimoff RJ, Cheong TH, Olha AE, Charbonneau M, Levy RD, Cosio MG, et al. Mechanisms of apnea termination in obstructive sleep apnea. Role of chemoreceptor and mechanoreceptor stimuli. Am J Respir Crit Care Med. 1994;149(3 Pt 1):707–14.
Laveneziana P, Albuquerque A, Aliverti A, Babb T, Barreiro E, Dres M, et al. ERS statement on respiratory muscle testing at rest and during exercise. Eur Respir J. 2019;53(6):1801214.
Luo YM, Moxham J. Measurement of neural respiratory drive in patients with COPD. Respir Physiol Neurobiol. 2005;146(2–3):165–74.
Luo YM, Polkey MI, Johnson LC, Lyall RA, Harris ML, Green M, et al. Diaphragm EMG measured by cervical magnetic and electrical phrenic nerve stimulation. J Appl Physiol (1985). 1998;85(6):2089–99.
Luo YM, Lyall RA, Lou Harris M, Rafferty GF, Polkey MI, Moxham J. Quantification of the esophageal diaphragm electromyogram with magnetic phrenic nerve stimulation. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1629–34.
Luo YM, Moxham J, Polkey MI. Diaphragm electromyography using an oesophageal catheter: current concepts. Clin Sci. 2008a;115(8):233–44.
Luo YM, Wu HD, Tang J, Jolley C, Steier J, Moxham J, et al. Neural respiratory drive during apnoeic events in obstructive sleep apnoea. Eur Respir J. 2008b;31(3):650–7.
Luo YM, Tang J, Jolley C, Steier J, Zhong NS, Moxham J, et al. Distinguishing obstructive from central sleep apnea events: diaphragm electromyogram and esophageal pressure compared. Chest. 2009;135(5):1133–41.
Luo YM, Li RF, Jolley C, Wu HD, Steier J, Moxham J, et al. Neural respiratory drive in patients with COPD during exercise tests. Respiration. 2011;81(4):294–301.
Luo YM, He BT, Wu YX, Yuan H, Xu J, Moxham J, et al. Neural respiratory drive and ventilation in patients with chronic obstructive pulmonary disease during sleep. Am J Respir Crit Care Med. 2014;190(2):227–9.
Marin JM, Soriano JB, Carrizo SJ, Boldova A, Celli BR. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med. 2010;182(3):325–31.
Morrell MJ, Harty HR, Adams L, Guz A. Breathing during wakefulness and NREM sleep in humans without an upper airway. J Appl Physiol (1985). 1996;81(1):274–81.
Patout M, Ramsay M, Mackie M, Lhuillier E, Grey N, Arbane G, et al. Home mechanical ventilation (HMV): setup and outcome in Europe. Eur Respir J. 2015;46:OA4780.
Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, et al. Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med. 2003;167(1):7–14.
Sinderby C, Spahija J, Beck J, Kaminski D, Yan S, Comtois N, et al. Diaphragm activation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163(7):1637–41.
Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, et al. High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2015;12(8):1219–25.
Stoohs RA, Blum HC, Knaack L, Butsch-von-der-Heydt B, Guilleminault C. Comparison of pleural pressure and transcutaneous diaphragmatic electromyogram in obstructive sleep apnea syndrome. Sleep. 2005;28(3):321–9.
Xiao SC, Lu YR, Guo HX, Qiu ZH, Luo YM. Effect of expiratory load on neural inspiratory drive. Chin Med J. 2012;125(20):3629–34.
Xiao SC, He BT, Steier J, Moxham J, Polkey MI, Luo YM. Neural respiratory drive and arousal in patients with obstructive sleep apnea hypopnea. Sleep. 2015;38(6):941–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature B.V. and Shanghai Jiao Tong University Press
About this chapter
Cite this chapter
Luo, YM., Luo, YM. (2022). Diaphragm EMG Recording and Its Application in Sleep Medicine. In: Pack, A.I., Li, Q.Y. (eds) Sleep and its Disorders. Translational Medicine Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-2168-2_9
Download citation
DOI: https://doi.org/10.1007/978-94-024-2168-2_9
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-024-2166-8
Online ISBN: 978-94-024-2168-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)