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Cyclosporine: Chemistry, Structure-Activity Relationships and Mode of Action

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Metabolic Control in Diabetes Mellitus Beta Adrenoceptor Blocking Drugs NMR Analysis of Cancer Cells Immunoassay in the Clinical Laboratory Cyclosporine

Part of the book series: Progress in Clinical Biochemistry and Medicine ((PCBM,volume 3))

Abstract

Cyclosporine is a cyclic peptide with a selective immunosuppressive action. One of its 11 amino acids is a novel amino acid, (4R)-4-((E)-2-butenyl-4,N-dimethyl-L-threonine, the preparation of which allowed the synthesis of cyclosporine and specifically modified analogues. Structure-activity relationships emerging from the study of modified cyclosporins suggest that a large portion of the cyclosporine molecule is involved in interactions with its lymphocyte receptor and that this includes amino acids 1, 2, 3 and 11.

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  1. Preclinical Research, Sandoz Ltd, CH-4002, Basel, Switzerland

    Roland M. Wenger, Trevor G. Payne & Max H. Schreier

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Wenger, R.M., Payne, T.G., Schreier, M.H. (1986). Cyclosporine: Chemistry, Structure-Activity Relationships and Mode of Action. In: Metabolic Control in Diabetes Mellitus Beta Adrenoceptor Blocking Drugs NMR Analysis of Cancer Cells Immunoassay in the Clinical Laboratory Cyclosporine. Progress in Clinical Biochemistry and Medicine, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70998-2_5

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