Skip to main content
SpringerLink
Log in

Antischistosomal effects of cyclosporin A

  • Immunosuppression and Inflammation
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Administration of cyclosporin A, a new selective immunosuppressive agent, to mice infected withSchistosoma mansoni resulted in a significant reduction in the number of mature and immature male and, to a greater extent, female worms. With lower, subeffective, doses a reduction in hemoglobinase activity and protein content of female schistosomes is produced. Evidence available so far suggests that the antischistosomal effects of cyclosporin A are mediated through a stimulation of host mechanisms directed against the parasite.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Y.-N. Cha, J. E. Bryam, H.S. Heine andE. Bueding,Effect of Schistosoma mansoni infection on hepatic drug metabolizing capacity of athymic nude mice, Am. J. trop. Med. Hyg.29, 234–238 (1980).

    Google Scholar 

  2. J.F. Borel,Essentials of cyclosporin A. A novel type of antilymphocyte agent, Trends Pharm. Sci.1, 146–149 (1980).

    Google Scholar 

  3. G.W. Luttermoser andW.B. Dewitt,Enhancement of Stibophen (faudin) activity against Schistosoma mansoni activity in mice by feeding purified semisynthetic diets, Am. J. trop. Med. Hyg.10, 541–546 (1961).

    Google Scholar 

  4. E. Bueding, C. Naquira, S. Bouwman andG. Rose,The antischistosomal activity of a nitrovinylfuran derivative (SQ 18,506) in mice and hamsters, J. Pharmac. exp. Ther.178, 402–410 (1971).

    Google Scholar 

  5. R.J. Eilers,Method and standard solution for hemoglobinometry, Am. J. clin. Path.47, 212–214 (1967).

    Google Scholar 

  6. M.H. Dresden andA.M. Deelder,Schistosoma mansoni: Thiol Proteinase Properties of Adult Worm ‘Hemoglobinase’. Expl Parasit.48, 190–197 (1979).

    Google Scholar 

  7. L.A. Barker, E. Bueding andA.R. Timms,The possible role of acetycholine on Schistosoma mansoni, Br. J. Pharmac. Chemother.26, 650–665 (1966).

    Google Scholar 

  8. S. Moore andW. Stein,Photometric Ninhydrin method for use in the chromatography of amino acids, J. biol. Chem.176, 367–388 (1948).

    Google Scholar 

  9. G.L. Peterson,A modification of the method of Lowry. et al. which is more generally applicable, Analyt. Biochem.83, 346–356 (1977).

    Google Scholar 

  10. O.H. Lowry, N.J. Rosebrough, A.I. Farr andR.J. Randall,Protein management with the Folin phenol reagent, J. biol. Chem.193, 265–273 (1951).

    Google Scholar 

  11. H.P. Striebel,4-isothiocyanato-4′-nitrodiphenylamine (C-9333-GO/CGP, 4540), an antihelmintic with an unusual spectrum against activity of intestinal nematodes, filariae and schistosomes, Experientia32, 47–48 (1976).

    Google Scholar 

  12. E. Bueding, R. Batzinger andG. Petterson,Antischistosomal and some toxicological properties of a nitrophenyl-amino-isothiocyanate (C9333-GO/CGP 4540), Experientia32, 604–606 (1976).

    Google Scholar 

  13. R. Batzinger, E. Bueding, R.S. Reddy andJ.H. Weisburger,Formation of a mutagenic drug metabolite by intestinal microorganisms, Cancer Res.38, 608–612 (1978).

    Google Scholar 

  14. D. Wiesinger andJ.F. Borel,Studies on the mechanism of action of cyclosporin A, Immunobiology156, 454–463 (1979).

    Google Scholar 

  15. A.D. Hess andP.J. Tutschka,Effect of cyclosporin A on human lymphocyte responses in vitro, J. Immun.124, 2601–2608 (1980).

    Google Scholar 

  16. R.Y. Calne, R. Rolles, D.J.G. White,Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaver organs: 32 kidneys, 2 pancreases and 2 livers, Lancetii, 1033–1036 (1979).

    Google Scholar 

  17. T.E. Starzl, R. Weilsoki, S.I. Watsoki, G. Klintmalm, G.P.J. Schroter, L.J. Koep, Y. Iwaki, P.U. Terasaki, andK.A. Porter,The use of cyclosporin A and prednisone in cadaver kidney transplantation, Surgery Gynec. Obstet.151, 17–26 (1980).

    Google Scholar 

  18. R.L. Powles, H.M. Clink, D. Spende, G. Morgenstern, J.G. Watson, T.J. Selby, M. Woods, A. Barrett, B. Jameson, J. Sloane, S.D. Lawler, H.E.M. Kay, D. Lawson, T.J. Mcelwain, andP. Alexander,Cyclosporin A to prevent graft-versushost-disease in man after allogeneic bonemarrow transplantation, Lanceti, 327–329 (1980).

    Google Scholar 

  19. A.R. Timms andE. Bueding,Studies of a proteolytic enzyme from Schistosoma mansoni, Br. J. Pharmac.14, 68–73 (1959).

    Google Scholar 

  20. R.A. Zussman, P.M. Bauman andI.C. Petruska,The role of ingested hemoglobin in the nutrition of Schistosoma mansoni, J. Parasit.56, 75–79 (1970).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathobiology and Department of Pharmacology and Experimental Therapeutics, Johns Hopkins Medical Institutions, 21205, Baltimore, Maryland, USA

    E. Bueding, J. Hawkins & Y. -N. Cha

Authors
  1. E. Bueding
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Hawkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. -N. Cha
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by grants from NIH (#GM 16492-12) and the Agency for International Development (#AID/ta-C-1312).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bueding, E., Hawkins, J. & Cha, Y.N. Antischistosomal effects of cyclosporin A. Agents and Actions 11, 380–383 (1981). https://doi.org/10.1007/BF01982474

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01982474

Keywords

Search

Navigation