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The BALB/c Mouse as a Model to Study Orthopoxviruses

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The BALB/c Mouse

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 122))

Abstract

The interaction of inbred mice such as the BALB/c group of strains with an infectious agent constitutes a system in which one can study either the pathogenesis of the agent or the host defense mechanisms operative during the disease process. Infection of the BALB/c mouse with poxviruses is such a model system.

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References

  • Allen AM, Clarke GL, Ganaway JR, Lock A, Werner RM (1981) Pathology and diagnosis of mousepox. Lab Anim Sci 31: 599–608

    PubMed  CAS  Google Scholar 

  • Baxby D (1977) Possible antigenic sub-divisions within the variola/vaccinia subgroup of poxviruses. Arch Virol 54: 143–145.

    Article  PubMed  CAS  Google Scholar 

  • Bennink JR, Doherty PC (1980) T cells that encounter virus in the complete absence of a particular H-2 antigen are nonresponsive when stimulated again in the context of that H-2 atigen. J Exp Med 151: 166–173

    Article  PubMed  CAS  Google Scholar 

  • Berger ML (1982a) Immunologic requirements for adoptive transfer of ectromelia virus meningitis. J Neuropathol Exp Neurol 41: 18–33.

    Article  PubMed  CAS  Google Scholar 

  • Berger ML (1982b) The role of the major histocompatibility complex in the adoptive transfer of ectromelia virus meningitis. J Neuropathol Exp Neurol 41: 34–44

    Article  PubMed  CAS  Google Scholar 

  • Biddison WE, Hansen TH, Levy RB, Doherty PC (1978) Gene products in virus immune thymus derived cell recognition: Evidence for an H-2L restricted thymus derived cell response. J Exp Med 148: 1678–1686

    Article  PubMed  CAS  Google Scholar 

  • Blanden RV (1974) T cell response to virual and bacterial infection. Transplant Rev 19: 56–88

    PubMed  CAS  Google Scholar 

  • Blanden RV, McKenzie IF, Kees U, Melvoid RW, Kohn HI (1977) Cytotoxic T-cell response to ectromelia virus-infected cells. Different H-2 requirements for triggering precursor T-cell induction or lysis by effector T cells defined by the BALB/c-H-2db mutation. J Exp Med 146: 869–880

    Article  PubMed  CAS  Google Scholar 

  • Borysiewicz J, Mizerski J, Pryjma J (1977) Effect of methisazone on immune response in mice. Chemotherapy 23: 276–281

    Article  PubMed  CAS  Google Scholar 

  • Bosse DC, Campbell WG, JR, Cassel WA (1982) Light and electron microscopic studies of the pathogenesis of vaccinia virus infection in mouse brain (41479). Proc Soc Exp Biol Med 171: 72–78

    PubMed  CAS  Google Scholar 

  • Buller RML, Smith GL, Cremer K, Notkins AL, Moss B (1985) Infectious vaccinia virus TK recombinants that express foreign genes are less virulent than wild-type virus in mice. In: Chanock R, Lerner R (ed) Vaccines 85: molecular and chemical basis of resistance to viral, bacterial and parasitic disease. PP 163–167

    Google Scholar 

  • Buller RML, (1985) Isolation and characterization of mutants of ectromelia virus (Strain NIH 79) which are less virulent than wild-type virus in BALB/cByJ mice. In Bhatt P, Morse III, HC New A Jacoby R (eds) Viral and Mycoplasma Infections of Laboratory Rodents: Effects on biomedical research in press

    Google Scholar 

  • Burnet FM, Boake WD (1946) The relationship between the virus of infectious ectromelia of mice and vaccinia virus. J Immunol 53: 1–13

    PubMed  CAS  Google Scholar 

  • Cremer KJ, Mackett M, Wohlenberg C, Notkins AL, Moss B (1985) Vaccinia virus recombinant that expresses the herpes simplex virus type-1 glycoprotein D protects mice against lethality and the establishment of latent herpes infection. Science in press.

    Google Scholar 

  • Dixon CW (1962) Smallpox. J and A Churchill Ltd, London P.96.

    Google Scholar 

  • Doherty PC, Bennink JR (1979) Vaccinia specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus H-2 complex. J Exp Med 149: 150–157

    Article  PubMed  CAS  Google Scholar 

  • Doherty PC, Schwartz DH, Bennink JR, Korngold R (1981) Factors influencing the vaccinia-specific cytotoxic response of thymocytes from normal and chimeric mice. Transplant Proc 13: 1850–1853

    PubMed  CAS  Google Scholar 

  • Ermolaeva SN, Blandova ZK, Dushkin VA (1974) Genetic study on susceptibility of different mouse lines to ectromelia virus. Sov Genet 8:681–783

    PubMed  CAS  Google Scholar 

  • Fenner F (1947) Studies in infectious ectromelia of mice. I. Immunization of mice against ectromelia with living vaccinia virus. Aust J Exp Biol Med Sci 25: 257–274

    Article  PubMed  CAS  Google Scholar 

  • Fenner F (1948) The pathogenesis of the acute exanthems. An interpretation based upon experimental investigations with mouse-pox (infectious ectromelia of mice). Lancet ii: 915–920

    Article  Google Scholar 

  • Fenner F (1982) Mousepox. In: Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research, volume II Diseases, Academic Press, New York p 208–230

    Google Scholar 

  • Ferrante A, O’Keefe DE, Thong YH (1980) Induction of suppressor cells in mice following vaccinia virus infection. Med Microbiol Immunol (Berl) 168: 227–233

    Article  CAS  Google Scholar 

  • Jacoby RO, Bhatt PN, Johnson EA, Paturzo FX (1983) Pathogenesis of vaccinia (IHD-T) virus infection in BALB/cAnN mice. Lab Anim Sci 33: 435–441

    PubMed  CAS  Google Scholar 

  • Kees VR, Blanden RV (1976) A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection. J Exp Med 143: 450–455.

    Article  PubMed  CAS  Google Scholar 

  • Lane JM, Ruben FL, Neff JM, Miller JD (1969) Complications of smallpox vaccination, 1968. National surveillance in the United States. N Eng J Med 281: 1201–1208

    Article  CAS  Google Scholar 

  • Mackett M, Archard LC (1979) Conservation and variation in orthopoxvirus genome structure. J Gen Virol 45: 683–701

    Article  PubMed  CAS  Google Scholar 

  • Moss B (1978) Poxviruses. In Nayak D (ed) The Molecular Biology of Animal Viruses, Vol 2, M. Dekker, NY p 849–898

    Google Scholar 

  • Moss B (1984) The use of virus vectors for vaccines. In: Bell R, Torrigiani G (eds) New Approaches to Vaccine Development, Schwabe and Co., AG, Basel p 167–177

    Google Scholar 

  • Moss B (1985) Principles of virus replication: Poxviruses. In: Fields B, (ed) Human viral diseases, Raven Press, New York in press

    Google Scholar 

  • Mullbacher A, Blanden RV, Brenan M (1983) Neonatal tolerance of major histocompatibility complex antigens alters Ir gene control of the cytotoxic T cell response to vaccinia virus. J Exp Med 157: 1324–1338

    Article  PubMed  CAS  Google Scholar 

  • Muller HK, Wittek R, Schaffner, W, Schumperli A, Menna A, Wyler R (1977) Comparison of five poxvirus genomes by analysis with restriction endonucleases HindIII, BamI and EcoRI. J Gen Virol 38: 135–147

    Article  Google Scholar 

  • O’Neill HC, Blanden RV (1983) Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice. Infect Immun 41: 1391–1394

    PubMed  Google Scholar 

  • O’Neill HC, Blanden RV, O’Neill TJ (1983) H-2 linked control of resistance to ectromelia virus infection in BIO congenic mice. Immunogenetics 18: 255–265.

    Article  PubMed  Google Scholar 

  • Pang T, Blanden RV (1977) Genetic factors in the stimulation of T cell responses against ectromelia virus-infected cells role of H-2K, H-2D and H-2I genes. Aust J Exp Biol Med Sci 55: 549–559

    Article  PubMed  CAS  Google Scholar 

  • Schell K (1960) Studies on the innate resistance of mice to infection with mousepox. II. Route of inoculation and resistance; and some observations on the inheritance of resistance. Aust J Exp Biol Med Sci 38: 289–300

    Article  PubMed  CAS  Google Scholar 

  • Siegel S (1956) Wilcoxon 2-sample test. In: Non parametric Statistics for Behavioral Sciences, McGraw-Hill Book, Inc. New York p 116–126

    Google Scholar 

  • Simon J, Werner GT (1979) Vaccinia virus infection of the central nervous system in X-irradiated mice. Infect Immun 25: 1035–1042

    PubMed  CAS  Google Scholar 

  • Takahashi M, Kameyama S, Kato, Kamahora J (1959) The immunological relationship of the poxvirus group. Biken’s J 2: 27–29

    Google Scholar 

  • Wallace GD, Buller RML (1985a) Kinetics of ectromelia virus (mousepox) transmission and clinical response in C57BL/6J, BALB/cByJ and AKR/J mice. Lab Animal Sci 35: 41–46

    CAS  Google Scholar 

  • Wallace GD, Buller RML (1985b) Ectromelia virus (mousepox): biology, epizootiology, prevention and control. In Bhatt P, Morse III HC, New A, Jacoby R (eds) Viral and Mycoplasma Infections of Laboratory Rodents: Effects on Biomedical research in press

    Google Scholar 

  • Wallace GD, Buller RML, Morse III HC (1985) Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality, submitted for publication

    Google Scholar 

  • Werner GT, Jentzsch U, Metzger E, Simon J (1980) Studies on poxvirus infections in irradiated animals. Archives of Virology 64: 247–256

    Article  PubMed  CAS  Google Scholar 

  • Wilson GS (1967) In: The hazards of Immunization. Athlone, London p 159–169.

    Google Scholar 

  • Zgorniak-Nowosielska I, Gatkiewicz A, Veckenstedt A, Beladi I (1980) Effect of N, N’-bis (methylisatin-beta-thiosemicarbazone)-2-methylpiperazine against virus-induced encephalitis in mice. Acta Virol 24: 439–444

    PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Burki K, Cottier F, De Dossodo S, Althage A, Illmensee K (1983) Thymus differentiation and T cell specificity in nu-nu plus-plus mouse aggregation chimeras. Eur Mol Biol Organ 2: 1665–1672

    CAS  Google Scholar 

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Authors
  1. R. M. L. Buller
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20205, Bethesda, MD, USA

    Michael Potter M.D. (Chief) (Chief)

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© 1985 Springer-Verlag Berlin Heidelberg

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Buller, R.M.L. (1985). The BALB/c Mouse as a Model to Study Orthopoxviruses. In: Potter, M. (eds) The BALB/c Mouse. Current Topics in Microbiology and Immunology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70740-7_22

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  • DOI: https://doi.org/10.1007/978-3-642-70740-7_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70742-1

  • Online ISBN: 978-3-642-70740-7

  • eBook Packages: Springer Book Archive

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