Skip to main content
SpringerLink
Log in

Lymphoid and Myeloid Tumors, Pathology of the Uterine Corpus

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 5 Accesses

Uterus Hematolymphoid Lesions (General Entry)

Description

Uterine lymphoma is rare and accounts for less than 1% of all extranodal lymphoma (Freeman et al., 1972). It affects females with an average age of 50 years old (Dursun et al., 2005). The most common presentation is abnormal vaginal bleeding, and less commonly pelvic or abdominal pain (Ferry & Young, 1997) and systemic symptoms such as fever or weight loss (Dursun et al., 2005; Ferry & Young, 1997). Uterine lymphomas have a relatively good prognosis (Ferry & Young, 1997; Vang et al., 2001) with the majority being Ann Arbor stage I rather than stage II (Chan et al., 2005). The disease free survival is reported between 70% and 90% (Chan et al., 2005; Dursun et al., 2005).

The differential diagnosis of uterine lymphoma includes florid reactive lymphoid hyperplasia, chronic inflammatory processes, spindle cell sarcoma, low grade endometrial stromal sarcoma, and embryonal rhabdomyosarcoma. However, the discohesive monotonous tumor...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Al-Katib, A. M., Ebrahim, A. S., Kandouz, M., Zaiem, F., Raufi, A., Ebrahim, S., Mohamed, A., Emara, N., & Gabali, A. M. (2020). Isolation and characterization of a CD34 + sub-clone in B-cell lymphoma. Oncotarget, 14;11(2), 148–160.

    Article  Google Scholar 

  • Bennett, J. A., Oliva, E., Nardi, V., Lindeman, N., Ferry, J. A., & Louissaint, A. (2016). Primary endometrial marginal zone lymphoma (MALT lymphoma). The American Journal of Surgical Pathology, 40, 1217–1223.

    Article  PubMed  Google Scholar 

  • Cao, X.-X., Li, J., Cai, H., Zhang, W., Duan, M.-H., & Zhou, D.-B. (2017). Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 and CD79B mutations. Annals of Hematology, 96, 1867–1871.

    Article  CAS  PubMed  Google Scholar 

  • Chan, J. K., Loizzi, V., Magistris, A., et al. (2005). Clinicopathologic features of six cases of primary cervical lymphoma. American Journal of Obstetrics and Gynecology, 193, 866–872.

    Article  PubMed  Google Scholar 

  • Dursun, P., Gultekin, M., Bozdag, G., et al. (2005). Primary cervical lymphoma: Report of two cases and review of the literature. Gynecologic Oncology, 98(3), 484–489.

    Article  PubMed  Google Scholar 

  • Ferry, J., & Young, R. (1997). Malignant lymphoma of the genitourinary tract. Current Diagnostic Pathology, 4, 145–169.

    Article  Google Scholar 

  • Freeman, C., Berg, J., & Cutler, S. (1972). Occurrence and prognosis of extranodal lymphomas. Cancer, 29(1), 252–260.

    Article  CAS  PubMed  Google Scholar 

  • Kosari, F., Daneshbod, Y., Parwaresch, R., et al. (2005). Lymphomas of the female genital tract: A study of 186 cases and review of the literature. The American Journal of Surgical Pathology, 29(11), 1512–1520.

    Article  PubMed  Google Scholar 

  • Magnoli, F., Cimetti, L., Bernasconi, B., et al. (2016). Primary extranodal marginal cell lymphoma, MALT type, of the endometrium arising in a patient with rheumatoid arthritis: Report of a case. International Journal of Gynecological Pathology, 35, 327–332.

    Article  PubMed  Google Scholar 

  • Nasioudis, D., Kampaktsis, P. N., Frey, M., Witkin, S. S., & Holcomb, K. (2017). Primary lymphoma of the female genital tract: An analysis of 697 cases. Gynecologic Oncology, 145, 305–309.

    Article  PubMed  Google Scholar 

  • Sun, J., Zhang, J., Ling, Q., Luo, Y., Wu, S., Liang, Z., Zhong, D., & Zeng, X. (2015). Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. Virchows Archiv, 466, 93–100.

    Article  CAS  PubMed  Google Scholar 

  • Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., & Thiele, J. (2017). WHO classification of tumors of hematopoietic and lymphoid tissues (revised) (4th ed.). IARC: Lyon.

    Google Scholar 

  • Vang, R., Medeiros, L. J., Fuller, G. N., et al. (2001). Non-Hodgkin’s lymphoma involving the gynecologic tract: A review of 88 cases. Advances in Anatomic Pathology, 8(4), 200–217.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Detroit Medical Center/Wayne State University, Detroit, MI, USA

    Feras Zaiem

Authors
  1. Feras Zaiem
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Feras Zaiem .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Zaiem, F. (2022). Lymphoid and Myeloid Tumors, Pathology of the Uterine Corpus. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5630-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5630-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation