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Primary diffuse large B-cell lymphoma of the ovary is of a germinal centre B-cell-like phenotype

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Abstract

Primary ovarian lymphoma is rare. To better understand the clinicopathological and molecular features of these tumours, we studied 14 patients (age range 13 to 74 years, mean 46.9 years) with non-Hodgkin’s lymphoma who initially presented with an ovarian tumour. The clinicopathological features were reviewed and tissue samples were studied by immunohistochemistry and for immunoglobulin gene rearrangement, presence of Epstein Barr virus and for MYC and BCL-2 rearrangements by fluorescence in situ hybridisation. The most common symptoms were abdominal pain and abdominal distension. Ten patients had a unilateral (7 left, 3 right) ovarian mass and 4 had bilateral ovarian masses, size range 4 to 13 cm (mean, 7.9 cm). Of the 14 lymphomas, 12 were classified as diffuse large B-cell lymphoma (DLBCL) and 2 as Burkitt lymphoma. The Burkitt lymphomas had a MYC rearrangement. The DLBCLs were of the germinal centre B-cell-like subtype. One DLBCL patient had MYC and BCL2 rearrangements. The treatment consisted of various combinations of surgery, chemotherapy and radiotherapy. The follow-up period ranged from 3 to 56 months. During the follow-up period, 8 patients died of disease, 4 were alive with disease, and 2 were alive without disease. Most primary ovarian lymphomas are of germinal centre B-cell-like subtype DLBCL, which have high proliferative activity and poor prognosis.

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Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan, Dongcheng District, 100730, Beijing, People’s Republic of China

    Jian Sun, Jing Zhang, Qing Ling, Yufeng Luo, Shafei Wu, Zhiyong Liang, Dingrong Zhong & Xuan Zeng

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  1. Jian Sun
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  2. Jing Zhang
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  3. Qing Ling
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  4. Yufeng Luo
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  5. Shafei Wu
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  6. Zhiyong Liang
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  7. Dingrong Zhong
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  8. Xuan Zeng
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Corresponding authors

Correspondence to Dingrong Zhong or Xuan Zeng.

Additional information

Jian Sun and Jing Zhang contributed equally to this work.

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Sun, J., Zhang, J., Ling, Q. et al. Primary diffuse large B-cell lymphoma of the ovary is of a germinal centre B-cell-like phenotype. Virchows Arch 466, 93–100 (2015). https://doi.org/10.1007/s00428-014-1682-7

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  • DOI: https://doi.org/10.1007/s00428-014-1682-7

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