Abstract
Corpus callosotomy is a palliative procedure for patients with multifocal or diffuse drug-resistant seizures not amenable to resective epilepsy surgery. It is usually indicated to mitigate seizures in patients with drug refractory epilepsy, especially in children. The goal is to achieve a potential reduction in seizure frequency or intensity and to offer a better quality of life to the patients and relatives. Callosotomy can be performed using basic microsurgical techniques or via endoscopy. Moreover, stereotactic laser interstitial thermal therapy and gamma knife radiosurgery have recently been used to reduce the invasiveness of the procedure. However, data available on the long-term results of these techniques are not enough to evidence their effectiveness.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Musiek FE. Neuroanatomy, neurophysiology, and central auditory assessment: part III. Corpus callosum and efferent pathways. Ear Hear. 1986;7:349–58.
Wada JA. Midline subcortical structures for transhemispheric ictal and interictal transmission. In: Reeves AG, Roberts DW, editors. Epilepsy and the corpus callosum 2. advances in behavioral biology, vol. 45. New York: Plenum; 1995. p. 61–78.
Asadi-Pooya AA, Sharan A, Nei M, Sperling MR. Corpus callosotomy. Epilepsy Behav. 2008;13(2):271–8.
Maxwell RE, Gates JR, Gumnit RJ. Corpus callosotomy at the University of Minnesota. In: Engel Jr J, editor. Surgical treatment of the epilepsies. New York: Raven Press; 1986. p. 659–66.
Van Wagenen WP, Herren RY. Surgical divisions of commissural pathways in the corpus callosum: relation to spread of an epileptic attack. Arch Neurol Psychiatr. 1940;44:740–59.
Mathews MS, Linskey ME, Binder DK. Wiliam P. van Wagenen and the first corpus callosotomies for epilepsy. J Neurosurg. 2008;108(3):608–13.
Vaddiparti A, Huang R, Blihar D, Du Pleissis M, Montalbano MJ, Tubbs S, Loukas M. The evolution of the corpus callosotomy for epilepsy management. World Neurosurg. 2021;145:455–61.
Bogen JE, Fisher ED, Vogel PJ. Cerebral commissurotomy. A second case report. JAMA. 1965;194(12):1328–9.
Park EK, Kim DS. Corpus callosotomy in pediatric intractable epilepsy: microsurgical technique implication and variation. In: Gadze ZP, editor. Epilepsy in children—clinical and social aspects. Chicago, IL: InTech; 2011.
Wilson DH, Reeves A, Gazzaniga M. Division of the corpus callosum for uncontrollable epilepsy. Neurology. 1978;28(7):649–53.
Bahuleyan B, Vogel TW, Robinson S, Cohen AR. Endoscopic total corpus callosotomy: cadaveric demonstration of a new approach. Pediatr Neurosurg. 2011;47(6):455–60.
Chandra SP, Kurwale NS, Chibber SS, Banerji J, Dwivedi R, Garg A, Bal C, Tripathi M, Sarkar C, Tripathi M. Endoscopic-assisted (through a minicraniotomy) corpus callosotomy combined with anterior, hippocampal, and posterior commissurotomy in Lennox-Gastaut syndrome: a pilot study to establish its safety and efficacy. Neurosurgery. 2016;78(5):743–51.
Sood S, Rajah GB. Endoscopic callosotomy and hemispherotomy: bimanual endoscopic technique. In: Villemure JG, Baltuch GH, Cukiert A, editors. Operative techniques in epilepsy surgery. Stuttgart: Thieme; 2020.
Sood S, Marupudi NI, Asano E, Haridas A, Ham SD. Endoscopic corpus callosotomy and hemispherotomy. J Neurosurg Pediatr. 2015;16(6):681–6.
Smyth MD, Vellimana AK, Asano E, Sood S. Corpus callosotomy-open and endoscopic surgical techniques. Epilepsia. 2017;58(S1):73–9.
Sood S, Asano E, Altinok D, Luat A. Endoscopic posterior interhemispheric complete corpus callosotomy. J Neurosurg Pediatr. 2016;25:689–92.
Eder HG, Feichtinger M, Pieper T, Kurschel S, Schroettner O. Gamma knife radiosurgery for callosotomy in children with drug-resistant epilepsy. Childs Nerv Syst. 2006;22(8):1012–7.
Feichtinger M, Schröttner O, Eder H, Holthausen H, Pieper T, Unger F, Holl A, Gruber L, Körner E, Trinka E, Fazekas F, Ott E. Efficacy and safety of radiosurgical callosotomy: a retrospective analysis. Epilepsia. 2006;47(7):1184–91.
Pendl G, Eder HG, Schroettner O, Leber KA. Corpus callosotomy with radiosurgery. Neurosurgery. 1999;45:303–8.
Palma AE, Wicks RT, Popli G, Couture DE. Corpus callosotomy via laser interstitial thermal therapy: a case series. J Neurosurg Pediatr. 2018;23(3):303–7.
Abou-khalil BW. When should corpus callosotomy be offered as palliative therapy. Epilepsy Curr. 2010;10(1):9–10.
Pinard JM, Delalande O, Chiron C, Soufflet C, Plouin P, Kim Y, Dulac O. Callosotomy for epilepsy after West syndrome. Epilepsia. 1999;40(12):1727–34.
Stigsdotter-Broman L, Olsson I, Flink R, Rydenhag B, Malmren K. Long term follow-up after callosotomy-a prospective population based, observational study. Epilepsia. 2014;55(2):316–21.
Wong TT, Kwan SY, Chang KP, Hsiu-Mei W, Yang TF, Chen YS, Yi-Yen L. Corpus callosotomy in children. Childs Nerv Syst. 2006;22(8):999–1011.
Lemmon ME, Terao NN, Ng Y, Reisig W, Rubenstein JE, Kossoff EH. Efficacy of the ketogenic diet in Lennox-gastaut syndrome: a retrospective review of one institution's experience and summary of the literature. Dev Med Child Neurol. 2012;54(5):464–8.
Luat AF, Asano E, Kumar A, Chugani HT, Sood S. Corpus callosotomy for intractable epilepsy revisited: the children's hospital of Michigan series. J Child Neurol. 2017;32(7):624–9.
Schaller K, Cabrilo I. Corpus callosotomy. Acta Neurochir. 2016;158(1):155–60.
Chen PC, Messina SA, Castillo E, Baumgartner J, Seo JH, Skinner H, Gireesh ED, Lee KH. Altered integrity of corpus callosum in generalized epilepsy in relation to seizure lateralization after corpus callosotmy. Neurosurg Focus. 2020;48(4):E15.
Arifin MT, Muttaqin Z, Bakhtiar Y, Andar E, Priambada D, Kurnia H, Risdianto A, Tsaniadi K, Kusnarto G, Bunyamin J. Seizure outcomes in patients with complete versus anterior corpus callosotomy: analysis of outcome. Int J Gen Med. 2020;13:105–10.
Rathore C, Abraham M, Rao RM, George A, Sarma PS, Radhakrishnan K. Outcome after corpus callosotomy in children with injurious drop attacks and severe mental retardation. Brain and Development. 2007;29(9):577–85.
Pilcher WH, Rusyniak WG. Complications of epilepsy surgery. Neurosurg Clin N Am. 1993;4(2):311–25.
Jalilian L, Limbrick DD, Sterger-may K, Johnston J, Powers AK, Smyth MD. Complete versus anterior two-third corpus callosotomy in children: analysis of outcome. J Neurosurg. 2010;6(3):257–66.
Clarke DF, Wheless JW, Chacon MM, et al. Corpus callosotomy: a palliative therapeutic technique may help identify resectable epileptogenic foci. Seizure. 2007;16:545–53.
Hashizume K, Tanaka T, Kunimuto M, Yonemasu Y. Image-guided surgery for epilepsy. Neurol Surg. 1997;25(4):329–35.
Hodaie M, Musharbash A, Otsubo H, Snad OC, Chitoku S, Holowka S, Hoffman HJ, Rutka JT. Image-guided, frameless stereotactic sectioning of the corpus callosum in children with intractable epilepsy. Pediatr Neurosurg. 2001;34(6):286–94.
Fiol ME, Gates JR, Mireles R, Maxwell RE, Erickson DM. Value of intraoperative EEG changes during corpus callosotomy in prediction surgical results. Epilepsia. 1993;34(1):74–8.
Kwan SY, Lin JH, Wong TT, Chang KP, Yiu CH. Prognostic value of electrocorticography finding during callosotomy in children with Lennox-gastaut syndrome. Seizure. 2005;14(7):470–5.
Uda T, Kunihiro N, Umaba R, Koh S, Kawashima T, Ikeda S, Ishimoto K, Goto T. Surgical aspects of corpus callosotomy. Brain Sci. 2021;11(12):1608.
Ho AL, Miller KJ, Cartmell S, Inoyama K, Fisher RS, Halpern CH. Stereotactic laser ablation of the splenium for intractable epilepsy. Epilep Behav Case Rep. 2016;5:23–6.
Lehner KR, Yeagle EM, Argyelan M, Klimaj Z, Du V, Megevand P, Hwang ST, Mehta AD. Validation of corpus callosotomy after laser interstitial thermal therapy: a multimodal approach. J Neurosurg. 2018:1–11.
Pruitt R, Gamble A, Black K, Schulder M, Mehta AD. Complication avoidance in laser interstitial thermal therapy: lessons learned. J Neurosurg. 2017;126:1238–45.
Bodaghabadi M, Bitaraf MA, Aran S, Alikhani M, Ashrafian H, Zahiri A, Alahverdi M. Corpus callosotomy with gamma knife radiosurgery for a case of intractable generalised epilepsy. Epileptic Disord. 2011;13(2):202–8.
Celis MA, Moreno-Jiménez S, Lárraga-Gutiérrez JM, Alonso-Vanegas MA, GarcÃa-Garduño OA, MartÃnez-Juárez IE, Fernández-Gónzalez MC. Corpus callosotomy using conformal stereotactic radiosurgery. Childs Nerv Syst. 2007;23(8):917–20.
Pressler RM, Binnie CD, Elwes RD, Polkey CE. Return of generalized seizures and discharges after callosotomy. Adv Neurol. 1999;81:171–82.
Huang Y, Yecies D, Bruckert L, Parker JJ, Ho AL, Kim LH, Fornoff L, Wintermark M, Porter B, Yeom KW, Halpern CH, Grant GA. Stereotactic laser ablation for completion corpus callosotomy. J Neurosurg Pediatr. 2019;2:1–9.
Rich CW, Fasano RE, Isbaine F, Saindane AM, Qiu D, Curry DJ, Gross RE, Willie JT. MRI-guided stereotactic laser corpus callosotomy for epilepsy: distinct methods and outcomes. J Neurosurg. 2021;22:1–13.
Singh H, Essayed WI, Deb S, Hoffman C, Schwartz TH. Minimally invasive robotic laser corpus callosotomy: a proof of concept. Cureus. 2017;9(2):e1021.
Caruso JP, Janjua MB, Dolce A, Price AV. Retrospective analysis of open surgical versus laser interstitial thermal therapy callosotomy in pediatric patients with refractory epilepsy. J Neurosurg Pediatr. 2021;27(4):420–8.
Cukiert A, Burattini JA, Mariani PP, Câmara RB, Seda L, Baldauf CM, Argentoni M, Baise-Zung C, Forster CR, Mello VA. Extended, one-stage callosal section for treatment of refractory secondarily generalized epilepsy in patients with Lennox-Gastaut and Lennox-like syndromes. Epilepsia. 2006;47(2):371–4.
Spencer SS, Spencer DD. Seizure types: results of partial and complete callosotomy in adults. In: Reeves AG, Roberts DW, editors. Epilepsy and the corpus callosum 2. Advances in behavioral biology, vol. 45. New York: Plenum; 1995. p. 145–52.
Shimizu H. Our experience with pediatric epilepsy surgery focusing on corpus callosotomy and hemispherotomy. Epilepsia. 2005;46(Suppl 1):30–1.
Chan AY, Rolston JD, Lee B, Vadera S, Englot DJ. Rates and predictors of seizure outcome after corpus callosotomy for drug-resistant epilepsy: a meta-analysis. J Neurosurg. 2018;1:1–10.
Purves SJ, Wada JA, Woodhurst WB. Corpus callosum section for complex partial seizures. In: Reeves AG, Roberts DW, editors. Epilepsy and the corpus callosum 2. Advances in behavioral biology, vol. 45. New York: Plenum; 1995. p. 175–82.
Téllez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. 2005;128(Pt 5):1188–98.
Petrozza PH. Brain cortex resection (for epilepsy). In: Fleisher LA, Roizen MF, editors. Essence of anesthesia practice. Third ed. Amsterdam: Elsevier; 2011. p. 414–5.
Maehara T, Shimizu H. Surgical outcome of corpus callosotomy in patients with drop attacks. Epilepsia. 2001;42(1):67–71.
Maehara T, Shimizu H, Oda M, Arai N. Surgical treatment of children with medically intractable epilepsy—outcome of various surgical procedures. Neurol Med Chir (Tokyo). 1996;36(5):305–9.
Nei M, O'Connor M, Liporace J, Sperling MR. Refractory generalized seizures: response to corpus callosotomy and vagal nerve stimulation. Epilepsia. 2006;47(1):115–22.
Kim DS, Yang KH, Kim TG, Chang JH, Chang JW, Choi JU, Lee BI. The surgical effect of callosotomy in the treatment of intractable seizure. Yonsei Med J. 2004;45(2):233–40.
Reeves AG, Risse G. Neurological effects of callosotomy. In: Reeves AG, Roberts DW, editors. Epilepsy and the corpus callosum 2. Advances in behavioral biology, vol. 45. New York: Plenum; 1995. p. 241–51.
Andersen B, Rogvi-Hansen B, Kruse-Larsen C, Dam M. Corpus callosotomy: seizure and psychosocial outcome. A 39-month follow-up of 20 patients. Epilepsy Res. 1996;23(1):77–85.
Jenssen S, Sperling MR, Tracy JI, Nei M, Joyce L, David G, O'Connor M. Corpus callosotomy in refractory idiopathic generalized epilepsy. Seizure. 2006;15(8):621–9.
Assal F, Schwartz S, Vuilleumier P. Moving with or without will: functional neural correlates of alien hand syndrome. Ann Neurol. 2007;62:301–6.
Burchiel KJ. Corpus callosotomy for intractable epilepsy in children. West J Med. 1993;158:66–7.
Hader W, Bezchlibnyk I, Pillay N, Wiebe S. Corpus callosotomy, risks and benefits: a systematic review of the evidence. Epilepsy Curr. 2012;12:1.
Fujimoto A, Hatano K, Nozaki T, Sato K, Enoki H, Okanishi T. Postoperative pneumocephalus on computed tomography might predict post-corpus callosotomy chemical meningitis. Brain Sci. 2021;11(5):638.
Sass KJ, Novelly RA, Spencer DD, Spencer SS. Postcallosotomy language impairments in patients with crossed cerebral dominance. J Neurosurg. 1990;72(1):85–90.
Malmgren K, Rydenhag B, Hallbook T. Reappraisal of corpus callosotomy. Curr Opin Neurol. 2015;28:175–81.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Benzagmout, M., Himmiche, M., Souirti, Z., El Asri, A.C. (2023). Partial and Complete Callosotomy of the Corpus Callosum. In: Turgut, M., Tubbs, R.S., Turgut, A.T., Bui, C.C. (eds) The Corpus Callosum. Springer, Cham. https://doi.org/10.1007/978-3-031-38114-0_33
Download citation
DOI: https://doi.org/10.1007/978-3-031-38114-0_33
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-38113-3
Online ISBN: 978-3-031-38114-0
eBook Packages: MedicineMedicine (R0)