Skip to main content

Toxic Lesions of the Corpus Callosum

  • Chapter
  • First Online:
The Corpus Callosum

Abstract

The corpus callosum (CC) provides the motor, sensory, and cognitive performance of the brain by connecting the stimuli originating from the cerebral cortex to the other. Marchiafava-Bignami disease is a rare disorder with a history of chronic alcohol use in all cases. In all cases, symmetrical lesions are present in the CC, causing progressive demyelination and necrosis. Heroin and cocaine addiction, on the other hand, cause diffusion restriction and microstructural changes in the CC, depending on the duration, dose and form of use. Carbon monoxide poisoning is one of the most common poisonings that affects many areas of the brain as well as the CC, leading to death with variable clinical features. As new techniques come to the forefront, the effects of toxic substances on the brain, especially on the CC, will be understood more clearly.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Starkey J, Kobayashi N, Numaguchi Y, Moritani T. Cytotoxic lesions of the corpus callosum that show restricted diffusion: mechanisms, causes, and manifestations. Radiographics. 2017;37(2):562–76.

    Article  PubMed  Google Scholar 

  2. Tian TY, PescadorRuschel MA, Park S, Liang JW. Marchiafava-Bignami disease. In: StatPearls; 2022.

    Google Scholar 

  3. Bachar M, Fatakhov E, Banerjee C, Todnem N. Rapidly resolving nonalcoholic marchiafava-bignami disease in the setting of malnourishment after gastric bypass surgery. J Investig Med High Impact Case Rep. 2018;6:1–4.

    Google Scholar 

  4. Boutboul D, Lidove O, Aguilar C, Klein I, Papo T. Marchiafava-Bignami disease complicating SC hemoglobin disease and plasmodium falciparum infection. Presse Med. 2010;39(9):990–9.

    Article  PubMed  Google Scholar 

  5. Cui Y, Zheng L, Wang X, Zhang W, Yuan D, Wei Y. Marchiafava-Bignami disease with rare etiology: a case report. Exp Ther Med. 2015;9(4):1515–7.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Heinrich A, Runge U, Khaw AV. Clinicoradiologic subtypes, of Marchiafava-Bignami disease. J Neurol. 2004;251:1050–9.

    Article  PubMed  Google Scholar 

  7. Dong X, Bai C, Nao J. Clinical and radiological features of Marchiafava-Bignami disease. Medicine (Baltimore). 2018;97(5):e9626.

    Article  PubMed  Google Scholar 

  8. Ma L, Hasan KM, Steinberg JL, Narayana PA, Lane SD, Zuniga EA, Kramer LA, Moeller FG. Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route. Drug Alcohol Depend. 2009;104(3):262–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Qiu YW, Jiang GH, Ma XF, Su HH, Lv XF, Zhuo FZ. Aberrant interhemispheric functional and structural connectivity in heroin-dependent individuals. Addict Biol. 2017;22(4):1057–67.

    Article  CAS  PubMed  Google Scholar 

  10. Tung CS, Wu SL, Tsou JC, Hsu SP, Kuo HC, Tsui HW. Marchiafava-Bignami disease with widespread lesions and complete recovery. Am J Neuroradiol. 2010;31(8):1506–7.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke’s encephalopathy. Neuroscience. 1999;91(2):429–38.

    Article  CAS  PubMed  Google Scholar 

  12. Fernandes LMP, Bezerra FR, Monteiro MC, Silva ML, de Oliveira FR, Lima RR, Fontes-Júnior EA, Maia CSF. Thiamine deficiency, oxidative metabolic pathways and ethanol-induced neurotoxicity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease. Eur J Clin Nutr. 2017;71:580.

    Article  CAS  PubMed  Google Scholar 

  13. He X, Sullivan EV, Stankovic RK, Harper CG, Pfefferbaum A. Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure. Neuropsychopharmacology. 2007;32(10):2207–16.

    Article  CAS  PubMed  Google Scholar 

  14. Kumar A, LaVoie HA, DiPette DJ, Singh US. Ethanol neurotoxicity in the developing cerebellum: underlying mechanisms and implications. Brain Sci. 2013;3(2):941–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Zieve L. Influence of magnesium deficiency on the utilization of thiamine. Ann N Y Acad Sci. 1969;162(2):732–43.

    Article  CAS  PubMed  Google Scholar 

  16. Costin BN, Miles MF. Molecular and neurologic responses to chronic alcohol use. Handb Clin Neurol. 2014;125:157–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Hillbom M, Saloheimo P, Fujioka S, Wszolek ZK, Juvela S, Leone MA. Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases. J Neurol Neurosurg Psychiatry. 2014;85(2):168–73.

    Article  PubMed  Google Scholar 

  18. Namekawa M, Nakamura Y, Nakano I. Cortical involvement in marchiafava-bignami disease can be a predictor of a poor prognosis: a case report and review of the literature. Intern Med. 2013;52(7):811–3.

    Article  PubMed  Google Scholar 

  19. Frazer KM, Richards Q, Keith DR. The long-term effects of cocaine use on cognitive functioning: a systematic critical review. Behav Brain Res. 2018;348(1):241–62.

    Article  CAS  PubMed  Google Scholar 

  20. Alballa T, Boone EL, Ma L, Snyder A, Moeller FG. Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian model averaging. PLoS One. 2021;16(7):e0254776.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Lee SH, Kim SS, Kim SH, Lee SY. Acute marchiafava-bignami disease with selective involvement of the precentral cortex and splenium: a serial magnetic resonance imaging study. Neurologist. 2011;17(4):213–7.

    Article  PubMed  Google Scholar 

  22. Witelson SF. Handandsexdifferences in theisthmusandgenu of thehumancorpuscallosum. A postmortem morphological study. Brain. 1989;112(Pt 3):799–835.

    Article  PubMed  Google Scholar 

  23. Tomasi D, Goldstein RZ, Telang F, Maloney T, Alia-Klein N, Caparelli EC, Volkow ND. Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception. Psychiatry Res. 2007;155(3):189–201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Taylor DG, Bushell MC. The spatial mapping of translational diffusion coefficients by the NMR imaging technique. Phys Med Biol. 1985;30(4):345–9.

    Article  CAS  PubMed  Google Scholar 

  25. Malow RM, West JA, Williams JL, Sutker PB. Personality disorders classification and symptoms in cocaine and opioid addicts. J Consult Clin Psychol. 1989;57(6):765–7.

    Article  CAS  PubMed  Google Scholar 

  26. Wang SC, Chen YC, Lee CH, Cheng CM. Opioid addiction, genetic susceptibility, and medical treatments: a review. Int J Mol Sci. 2019;20(17):4294.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Wetherill L, et al. Association of substance dependence phenotypes in the COGA sample. Addict Biol. 2015;20(3):617–27.

    Article  CAS  PubMed  Google Scholar 

  28. Volkow ND, Morales M. The brain on drugs: from reward to addiction. Cell. 2015;162(4):712–25.

    Article  CAS  PubMed  Google Scholar 

  29. Shen Y, Wang E, Wang X, Lou M. Disrupted integrity of white matter in heroin-addicted subjects at different abstinent time. J Addict Med. 2012;6(2):172–6.

    Article  PubMed  Google Scholar 

  30. Blasel S, Hattingen E, Adelmann M, Nichtweiß M, Zanella F, Weidauer S. Toxic leukoencephalopathy after heroin abuse without heroin vapor inhalation: MR imaging and clinical features in three patients. Clin Neuroradiol. 2010;20(1):48–53.

    Article  PubMed  Google Scholar 

  31. Chenoweth JA, Albertson TE, Greer MR. Carbon monoxide poisoning. Crit Care Clin. 2021;37(3):657–72.

    Article  PubMed  Google Scholar 

  32. Kim DM, Lee IH, Park JY, Hwang SB, Yoo DS, Song CJ. Acute carbon monoxide poisoning: MR imaging findings with clinical correlation. Diagn Interv Imaging. 2017;98(4):299–306.

    Article  CAS  PubMed  Google Scholar 

  33. Chen NC, Huang CW, Lui CC, Lee CC, Chang WN, Huang SH, Chen C, Chang CC. Diffusion-weighted imaging improves prediction in cognitive outcome and clinical phases in patients with carbon monoxide intoxication. Neuroradiology. 2013;2013:107–15.

    Article  Google Scholar 

  34. Lane SD, Moeller FG, Steinberg JL, Buzby M, Kosten TR. Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty. Am J Drug Alcohol Abuse. 2007;33(5):717–26.

    Google Scholar 

  35. Silver DAT, Cross M, Fox B, Paxton RM. Computed tomography of the brain in acute carbon monoxide poisoning. Clin Radiol. 1996;51(7):480–3.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bedel, F.M., Bilgeç, N. (2023). Toxic Lesions of the Corpus Callosum. In: Turgut, M., Tubbs, R.S., Turgut, A.T., Bui, C.C. (eds) The Corpus Callosum. Springer, Cham. https://doi.org/10.1007/978-3-031-38114-0_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-38114-0_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38113-3

  • Online ISBN: 978-3-031-38114-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics