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Toxic Agents

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Essentials of Cerebellum and Cerebellar Disorders

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Abstract

Cerebellum is vulnerable to intoxication and poisoning, especially in elderly patients and patients presenting structural lesions. The most common toxic agent is ethanol. Cerebellotoxic drugs include anti-epileptics, antineoplastics, lithium salts and heroin. Regarding environmental factors, chronic exposure to heavy metals, benzene derivatives and hyperthermia cause a cerebellar syndrome. Cerebellotoxicity should be listed in the differential diagnosis of cerebellar ataxia of unknown origin.

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Authors and Affiliations

  1. FNRS, ULB-Erasme, 808 Route de Lennik, 1070, Bruxelles, Belgium

    Mario Manto

  2. Service des Neurosciences, Université de Mons, 7000, Mons, Belgium

    Mario Manto

Authors
  1. Mario Manto
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Correspondence to Mario Manto .

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Editors and Affiliations

  1. Molecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. FNRS, ULB-Erasme, Bruxelles, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Jeremy D. Schmahmann

  6. Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China

    Ying Shen

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Manto, M. (2016). Toxic Agents. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_80

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