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The Structure, Function, and Modification of Non-coding RNAs in Cardiovascular System

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RNA Structure and Function

Part of the book series: RNA Technologies ((RNATECHN,volume 14))

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Abstract

The occurrence, development and prognosis of cardiovascular disease is a multi-factor and multi-path pathological process. In addition to environmental factors, epigenetic regulation mechanisms also play an important role in the occurrence and development of cardiovascular disease. The most common and abundant internal modification of mRNA is m6A. Together with RNA editing, which is an alternative RNA modification, both play important roles in regulating gene expression and affect the fate of RNA molecules. In addition, with the advances in next-generation sequencing technology, non-coding RNAs such as microRNA, long non-coding RNA, and circular RNA which are usually not involved in protein synthesis, but can participate in cardiac homeostasis, cardiomyocyte growth, proliferation and apoptosis, endothelial cell function, cardiac remodeling and repair, and inflammatory response through various mechanisms. Grasping the cognition of RNA modifications and non-coding RNAs in cardiovascular disease may help us to better understand mechanisms and develop new biomarkers or therapeutic strategies in cardiovascular disease. This chapter summarizes the roles of long non-coding RNA, microRNA, circular RNA, and RNA modification in cardiovascular diseases.

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Acknowledgements

This work was supported by the grants from National Natural Science Foundation of China (82020108002 and 82225005 to JJ Xiao, 82270291 to LJ Wang), the grant from Science and Technology Commission of Shanghai Municipality (23410750100, 21XD1421300 and 20DZ2255400 to JJ Xiao), the “Dawn” Program of Shanghai Education Commission (19SG34 to JJ Xiao), the Natural Science Foundation of Shanghai, China (23ZR1423000 to LJ Wang).

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Authors and Affiliations

  1. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, 200444, China

    Xinxin Cui, Lijun Wang & Junjie Xiao

  2. Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA

    Priyanka Gokulnath & Guoping Li

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  1. Xinxin Cui
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  2. Priyanka Gokulnath
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  3. Guoping Li
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  4. Lijun Wang
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Correspondence to Lijun Wang or Junjie Xiao .

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  1. NanoBioMedical Centre of Adam Mickiewicz University, Poznań, Poland

    Jan Barciszewski

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Cui, X., Gokulnath, P., Li, G., Wang, L., Xiao, J. (2023). The Structure, Function, and Modification of Non-coding RNAs in Cardiovascular System. In: Barciszewski, J. (eds) RNA Structure and Function. RNA Technologies, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-031-36390-0_19

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