Abstract
Zephyranthes citrina Baker is a bulbous herb, commonly known as yellow rain lily, and belongs to the family Amaryllidaceae. It is a native of tropical and subtropical America but nowadays it is cultivated as a popular ornamental herb in several parts of the world including India. This herb represents one of the richest sources of phytochemicals, especially alkaloids, and possesses great potential for pharmaceutical applications. It shows remarkable antiprotozoal, antimicrobial, anti-Alzheimer, cytotoxic, antioxidant, anti-inflammatory, analgesic, and other activities. This review is an effort to give a detailed study of the literature on the biological activities of Zephyranthes citrina. This review concludes that Zephyranthes citrina has great potential to treat various diseases and could be used as a source for novel health care products in the near future which requires further experimentation.
All authors contributed equally to this work. IB and DP critically reviewed the manuscript. All the authors read and approved the final manuscript.
Abbreviations
- AAs:
-
Amaryllidaceae alkaloids
- AChE:
-
Acetylcholinesterase
- BuChE:
-
Butyrylcholinesterase
- HeLa:
-
Henrietta Lacks
- MCF-7:
-
Michigan Cancer Foundation-7/Hormone-dependent breast cancer cell line
- MTT:
-
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide
- POP:
-
Prolyl oligopeptidase
- RP-UHPLC-MS:
-
Reversed-phase ultrahigh performance liquid chromatography mass spectrometry
- SCC-9:
-
Squamous carcinoma cancer cell line
- WHO:
-
World Health Organization
References
Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBP (2018) Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review. Phytother Res 32:2323–2339. https://doi.org/10.1002/ptr.6178
Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod 83:770–803. https://doi.org/10.1021/acs.jnatprod.9b01285
Rates SMK (2001) Plants as source of drugs. Toxicon 39:603–613. https://doi.org/10.1016/S0041-0101(00)00154-9
Abdala S, Martín-Herrera D, Benjumea D, Gutiérrez SD (2012) Diuretic activity of some Smilax canariensis fractions. J Ethnopharmacol 140:277–281. https://doi.org/10.1016/j.jep.2012.01.017
Singh A, Mishra A, Chaudhary R, Kumar V (2020) Role of herbal plants in prevention and treatment of parasitic diseases. J Sci Res 64:50–58. https://doi.org/10.37398/JSR.2020.640106
Mukheriee PK, Wahile A (2006) Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol 103:25–35. https://doi.org/10.1016/j.jep.2005.09.024
Sahoo N, Manchikanti P, Dey S (2010) Herbal drugs: standards and regulation. Fitoterapia 81:462–471. https://doi.org/10.1016/j.fitote.2010.02.001
Perez Gutierrez RM, Baez EG (2009) Cardioactive agents from plants. Mini Rev Med Chem 9:878–899. https://doi.org/10.2174/138955709788452612
Michel J, Abd Rani NZ, Husain K (2020) A review on the potential use of medicinal plants from Asteraceae and Lamiaceae plant family in cardiovascular diseases. Front Pharmacol 11:852. https://doi.org/10.3389/fphar.2020.00852
Paul D (2016) A review on biological activities of common Mallow (Malva sylvestris L.). Innovare J Life Sci 4:1–5
Paul D, Sinha SN (2016) An update on biological activities of medicinal plant Ipomoea quamoclit L. Trop Plant Res 3:186–190
Paul D, Biswas K, Sinha SN (2015) Biological activities of Adenium obesum (Forssk.) Roem. & Schult.: a concise review. Malaya J Biosci 2:214–221
Parida PK, Paul D, Chakravorty D (2020) The natural way forward: molecular dynamics simulation analysis of phytochemicals from Indian medicinal plants as potential inhibitors of SARS-CoV-2 targets. Phytother Res 34:3420–3433. https://doi.org/10.1002/ptr.6868
Bastida J, Lavilla R, Viladomat F (2006) Chemical and biological aspects of Narcissus alkaloids. Alkaloids. Chem Biol 63:87–179. https://doi.org/10.1016/S1099-4831(06)63003-4
Jin Z, Yao G (2019) Amaryllidaceae and sceletium alkaloids. Nat Prod Rep 36:1462–1488. https://doi.org/10.1039/C8NP00055G
Hume HH (1935) Duplications in Zephyranthes. Bull Torrey Bot Club 62:403–411. https://doi.org/10.2307/2480987
Meerow AW, Fay MF, Guy CL, Li QB, Zaman FQ, Chase MW (1999) Systematics of Amaryllidaceae based on cladistic analysis of plastid sequence data. Am J Bot 86:1325–1345. https://doi.org/10.2307/2656780
Katoch D, Singh B (2015) Phytochemistry and pharmacology of genus Zephyranthes. Med Aromat Plants 4:1000212. https://doi.org/10.4172/2167-0412.1000212
Fernández Alonso JL, Groenendijk JP (2004) A new species of Zephyranthes herb. S. L. (Amaryllidaceae, Hippeastreae), with notes on the genus in Colombia. Rev Acad Colomb Cienc Exactas Fis Nat 28:177–186
Tapia-Campos E, Rodriguez-Dominguez JM, Revuelta-Arreola MM, Van Tuyl JM, Barba-Gonzalez R (2012) Mexican Geophytes II. The genera Hymenocallis, Sprekelia and Zephyranthes. Floriculture Ornamental. Biotechnol 6:129–139
Cahlíková L, Valterová I, Macáková K, Opletal L (2011) Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora by GC/MS and their cholinesterase activity. Rev Bras Farmacogn 21:575–580. https://doi.org/10.1590/S0102-695X2011005000089
Syeed R, Mujib A, Malik MQ, Mamgain J, Ejaz B, Gulzar B, Zafar N (2021) Mass propagation through direct and indirect organogenesis in three species of genus Zephyranthes and ploidy assessment of regenerants through flow cytometry. Mol Biol Rep 48:513–526. https://doi.org/10.1007/s11033-020-06083-1
León H (1946) Flora de Cuba. Contribuciones Ocasionalesdel Museo de Historia Natural Colegio La Salle 8, Cultural S.A, La Habana
Müller-Doblies D, Müller-Doblies U (1996) Tribes and subtribes and some species combinations in Amaryllidaceae J St Hil R Dahlgren & al. 1985. Feddes Repert 107:S.c.1-9. https://doi.org/10.1002/fedr.4921070511
Singh UP, Gohain L, Maurya S, Singh A, Pandey VB, Singh AK (2010) Antifungal activity of two alkaloids of Zephyranthes citrina and their field efficacy against powdery mildew (Erysiphecichora cearum) of balsam. Arch Phytopathol Plant Prot 43:302–311. https://doi.org/10.1080/03235400701804067
Bobby RS, Stephen J, Omanakumari N (2003) Cytological investigations on the endosperm in Zephyranthes citrina herb. Cytologia 68:231–236. https://doi.org/10.1508/cytologia.68.231
Prakash J, Vedanayaki S (2019a) Organoleptic, fluorescence, qualitative and quantitative analysis of bulb extract of Zephyranthes citrina. J Pharmacogn Phytochem 8:2531–2536
Prakash J, Vedanayaki S (2019b) In-vitro cytotoxicity studies of methanolic bulb extract of Zephyranthes citrina on cervical cancer (Hela), breast cancer (MCF-7) and oral cancer (SCC-9). J Pharm Sci Res 11:2353–2356
Marta F (2005) Breeding of rainlilies. Bulbs: Bull Int Bulb Soc 7:25–32
Parmar G (2016) Zephyranthes citrina Baker (Amaryllidaceae), a new record for flora of Nepal. Bull Departm Plant Resour 38:14–15
Jin Z (2016) Amaryllidaceae and sceletium alkaloids. Nat Prod Rep 33:1318–1343. https://doi.org/10.1039/C6NP00068A
Watt JM, Breyer-Brandwijk MG (1962) The medicinal and poisonous plants of southern and eastern Africa. E and S Livingstone Ltd, Edinburgh/London
Agarwal VS (1997) Drug plants of India. Kalyani Publishers, New Delhi
Zhan G, Liu J, Zhou J, Sun B, Aisa HA, Yao G (2017a) Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors. Eur J Med Chem 127:771–780. https://doi.org/10.1016/j.ejmech.2016.10.057
Zhan G, Gao B, Zhou J, Liu T, Zheng G, Jin Z, Yao G (2023) Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities. Phytochemistry 207:113564. https://doi.org/10.1016/j.phytochem.2022.113564
Pettit GR, Gaddamidi V, Cragg GM (1984) Antineoplastic agents, 105. Zephyranthes grandiflora. J Nat Prod 47:1018–1020. https://doi.org/10.1021/np50036a020
Trimiño Ayllón Z, Castillo Rodríguez M, Spenglers Salabarría I (1989) Estudiopreliminar de Zephyranteseggersiana urban. Rev Cuba Farm 23:147–150
Konrath EL, Passos CDS, Klein-Júnior LC, Henriques AT (2013) Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer’s disease. J Pharm Pharmacol 65:1701–1725. https://doi.org/10.1111/jphp.12090
Kulhánková A, Cahlíková L, Novák Z, Macáková K, Kuneš J, Opletal L (2013) Alkaloids from Zephyranthes robusta Baker and their acetylcholinesterase- and butyrylcholinesterase-inhibitory activity. Chem Biodivers 10(6):1120–1127. https://doi.org/10.1002/cbdv.201200144
Ghosal S, Ashutosh RS (1985) (+)-Epimaritidine, an alkaloid from Zephyranthes rosea. Phytochemistry 24:635–637. https://doi.org/10.1016/S0031-9422(00)80796-7
Ghosal S, Singh SK, Srivastava RS (1986) Alkaloids of Zephyranthes flava. Phytochemistry 25:1975–1978. https://doi.org/10.1016/S0031-9422(00)81187-5
Kornienko A, Evidente A (2008) Chemistry, biology, and medicinal potential of narciclasine and its congeners. Chem Rev 108:1982–2014. https://doi.org/10.1021/cr078198u
Maheshwaran G, Bharathi AN, Selvi MM, Kumar MK, Kumar RM, Sudhahar S (2020) Green synthesis of silver oxide nanoparticles using Zephyranthes rosea flower extract and evaluation of biological activities. J Environ Chem Eng 8:104137. https://doi.org/10.1016/j.jece.2020.104137
Martínez GJ, Barboza GE (2010) Natural pharmacopoeia used in traditional Toba medicine for the treatment of parasitosis and skin disorders (Central Chaco, Argentina). J Ethnopharmacol 132:86–100. https://doi.org/10.1016/j.jep.2010.07.049
Zhan G, Zhou J, Liu J, Huang J, Zhang H, Liu R, Yao G (2017b) Acetylcholinesterase inhibitory alkaloids from the whole plants of Zephyranthes carinata. J Nat Prod 80:2462–2471. https://doi.org/10.1021/acs.jnatprod.7b00301
Daviña JR, Gianini Aquino AC, Rodríguez Mata OA, Tapia-Campos E, Barba-Gonzalez R, Honfi AI (2022) Chromosomic studies in Zephyranthes citrina Baker (Amaryllidaceae), a polyploid ornamental. J Basic Appl Genet XXXIII:89–95. https://doi.org/10.35407/bag.2022.33.01.08
Boit HG, Döpke W, Stender W (1957) Alkaloideaus Crinum-, Zephyranthes-, Leucojum-und Clivia-Arten. Chem Ber 90:2203–2206. https://doi.org/10.1002/cber.19570901013
Herrera MR, Machocho AK, Brun R, Viladomat F, Codina C, Bastida J (2001) Crinane and lycorane type alkaloids from Zephyranthes citrina. Planta Med 67:191–193. https://doi.org/10.1055/s-2001-11495
Iraida SS, Zaida TA, Esther AB, Carlos IP, Aristides RP (2001) Zephyramine: new alkaloid isolated from the bulbs of Zephyranthes citrina Baker. Rev CENIC Cienc Quim 32:61
Kohelová E, Maříková J, Korábečný J, Hulcová D, Kučera T, Jun D, Cahlíková L (2021) Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer’s disease: isolation, structural elucidation and biological activity. Bioorg Chem 107:104567. https://doi.org/10.1016/j.bioorg.2020.104567
Rehman MH, Saleem U, Ahmad B, Rashid M (2022) Phytochemical and toxicological evaluation of Zephyranthes citrina. Front Pharmacol 13:1007310. https://doi.org/10.3389/fphar.2022.1007310
Albuquerque BR, Heleno SA, Oliveira MBPP, Barros L, Ferreira ICFR (2021) Phenolic compounds: current industrial applications, limitations and future challenges. Food Funct 12:14–29. https://doi.org/10.1039/D0FO02324H
Schijlen EG, de Vos CHR, van Tunen AJ, Bovy AG (2004) Modification of flavonoid biosynthesis in crop plants. Phytochemistry 65:2631–2648. https://doi.org/10.1016/j.phytochem.2004.07.028
Deng Y, Lu S (2017) Biosynthesis and regulation of phenylpropanoids in plants. Crit Rev Plant Sci 36:257–290. https://doi.org/10.1080/07352689.2017.1402852
Prakash J, Vedanayaki S (2020) Biosynthesis, characterization and biological studies of silver nanoparticles using methanolic extract of bulb of Zephyranthes citrina. Int J Pharm Sci Res 11:4558–4566
Aslam N, Saeed MA, Rehman S, Iqbal J, Ansari MT, Maqsood Z (2016) Pharmacognostic evaluation, phytochemical screening and pharmacological activities of Zephyranthes citrina. Int J Biol Pharm Allied Sci 5:1983–1995
Prakash J, Vedanayaki S, Karthick K (2020) Removal of methylene blue dye using carbon derived from the bulb of Zephyranthes citrina by adsorption and kinetic studies. Int J Sci Technol Res 9:2027–2035. https://doi.org/10.14233/ajchem.2020.22562
Vedanayaki S, Prakash J (2021) Kinetics and isotherm studies for methylene blue dye removal using carbon derived from bulb of Zephyranthes citrina. New Innov Chem Biochem 4:113–125. https://doi.org/10.9734/bpi/nicb/v4/14433D
Acknowledgments
IB is grateful to the management, Kalyani Mahavidyalaya, Kalyani for providing the necessary facilities and encouragement.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Switzerland AG
About this entry
Cite this entry
Biswas, I., Paul, D. (2023). Phytochemical and Biological Aspects of Zephyranthes citrina Baker. In: Murthy, H.N., Paek, K.Y., Park, SY. (eds) Bioactive Compounds in the Storage Organs of Plants. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-031-29006-0_13-1
Download citation
DOI: https://doi.org/10.1007/978-3-031-29006-0_13-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-29006-0
Online ISBN: 978-3-031-29006-0
eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics