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Biomarkers in Oral Submucous Fibrosis

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Oral Submucous Fibrosis

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

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Abstract

Initiation and progression of oral submucous fibrosis (OSF) and its transformation to oral squamous cell carcinoma (OSCC) involve changes at the cellular, biochemical, molecular, and signalling pathway levels. These changes occur in both epithelial and connective tissue and have the potential to be used as biomarkers that can help in the diagnosis and management of OSF. This chapter describes the biomarkers identified by immunohistochemical methods classified under Epithelial markers, Connective tissue markers, Proliferative markers, Stemness markers, Markers of cell signalling and transcription factors, enzymes, glycoproteins, and metabolic markers.

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  1. Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, The Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, India

    Kannan Ranganathan & Kavitha Loganathan

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  1. Faculty of Dentistry Oral and Craniofacial Sciences, King's College London, London, UK

    Saman Warnakulasuriya

  2. Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, The TN Dr MGR Medical University, Chennai, Tamil Nadu, India

    Kannan Ranganathan

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Ranganathan, K., Loganathan, K. (2023). Biomarkers in Oral Submucous Fibrosis. In: Warnakulasuriya, S., Ranganathan, K. (eds) Oral Submucous Fibrosis. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-031-12855-4_15

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