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Voltage-Gated Calcium Channels as Key Regulators of Cancer Progression

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Voltage-Gated Calcium Channels

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Abstract

Calcium (Ca2+) is a universal and versatile second messenger regulating everything from cell growth to cell death. As a result, Ca2+ regulates many processes that are hallmarks of cancer, such as proliferation, angiogenesis, invasion and metastasis. One key part of the Ca2+ signalling toolkit is the voltage-gated calcium channel (VGCC) family; VGCCs are aberrantly expressed in many cancers, and emerging evidence implicates VGCCs in numerous key cancer processes. VGCCs are thus an attractive putative oncological target, especially since they are readily druggable and existing clinically available VGCC-targeting drugs could be repurposed to cancer. This chapter will explore the evidence for altered VGCC expression in cancer, its impact on cancer cell function and patient outcome, and avenues for future pharmacological intervention.

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Abbreviations

APA:

aldosterone-producing adenoma

BCF:

radiofrequency electromagnetic fields at breast cancer-specific frequencies

BK channels:

KCa1.1 calcium-activated potassium channels

Ca2+:

calcium

CDK2:

cyclin-dependent kinase 2

CXCL11:

C-X-C motif chemokine 11

DHT:

5α-dihydrotestosterone

EMT:

epithelial-mesenchymal transition

ER+:

estrogen receptor positive

ERK1/2:

extracellular signal-regulated protein kinase 1/2

HCC TICs:

hepatocellular carcinoma tumour-initiating cells

HER2+:

human epidermal growth factor receptor 2 positive

HIF-1:

hypoxia inducible factor 1

IL-6:

interleukin 6

MAPK:

mitogen-activated protein kinase

NED:

neuroendocrine differentiation

NF-kB:

nuclear factor kappa-light-chain-enhancer of activated B cells

NLK:

nemo-like kinase

PI3K:

phosphoinositide 3-kinase

PKC-β:

protein kinase C β

PTEN:

phosphatase and tensin homolog deleted on chromosome 10

VGCC:

voltage-gated Ca2+ channel

γH2AX:

γ H2A histone family member X

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Authors and Affiliations

  1. Department of Biology, York Biomedical Research Institute, University of York, York, UK

    Andrew D. James & William J. Brackenbury

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  1. Andrew D. James
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  2. William J. Brackenbury
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Correspondence to William J. Brackenbury .

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Editors and Affiliations

  1. Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

    Gerald Werner Zamponi

  2. Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic

    Norbert Weiss

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James, A.D., Brackenbury, W.J. (2022). Voltage-Gated Calcium Channels as Key Regulators of Cancer Progression. In: Zamponi, G.W., Weiss, N. (eds) Voltage-Gated Calcium Channels . Springer, Cham. https://doi.org/10.1007/978-3-031-08881-0_24

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