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Eupatilin: Sources, Extraction, Derivatives, and Pharmacological Activity

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  • First Online:
Handbook of Dietary Flavonoids

Abstract

Eupatilin (5,7-dihydroxy-3′,4′,6-trimethoxyflavone) is a pharmacologically active flavone obtained from several medicinal plants. Because it is a natural flavone, it has been discovered to be a major ingredient in the seeds, flowers, leaves, and stems of several plants, making it a therapeutic representative. Eupatilin is reported to have a variety of pharmacological characteristics, including anticancer, antioxidant, neuroprotective, antiallergic, cardioprotective, and anti-inflammatory properties. It has also been linked to the regulation of multiple cell-signaling pathways involved in proliferation, inflammation, and a variety of other diseases. It is predicted that eupatilin might be structurally optimized for the production of derivative analogues in order to improve its efficacy, reduce toxicity, and optimize absorption characteristics, ultimately leading to powerful therapeutic candidates. Despite current findings to support eupatilin’s numerous pharmacological effects, more research into its molecular mechanism of action is required to clarify the entire range of its pharmacological activities.

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Authors and Affiliations

  1. Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

    Hitesh Malhotra

  2. Chandigarh College of Pharmacy, Mohali, Punjab, India

    Aditya Ashri

  3. Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China

    Rajeev K. Singla

  4. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Rajeev K. Singla

  5. Department of Pharmacology, Indore Institute of Pharmacy, IIST Campus, Rau, Indore, Madhya Pradesh, India

    Rupesh K. Gautam

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  1. Hitesh Malhotra
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  2. Aditya Ashri
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  3. Rajeev K. Singla
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  4. Rupesh K. Gautam
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Corresponding authors

Correspondence to Rajeev K. Singla or Rupesh K. Gautam .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Malhotra, H., Ashri, A., Singla, R.K., Gautam, R.K. (2023). Eupatilin: Sources, Extraction, Derivatives, and Pharmacological Activity. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_84-1

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